Nav: Home

Weight loss led to reduction in inflammation

May 01, 2012

PHILADELPHIA -- Postmenopausal women who were overweight or obese and lost at least 5 percent of their body weight had a measurable reduction in markers of inflammation, according to a study published in Cancer Research, a journal of the American Association for Cancer Research.

"Both obesity and inflammation have been shown to be related to several types of cancer, and this study shows that if you reduce weight, you can reduce inflammation as well," said Anne McTiernan, M.D., Ph.D., director of the Prevention Center at the Fred Hutchinson Cancer Research Center in Seattle, Wash.

Women in the trial who were assigned to a weight loss intervention had a goal of 10 percent weight reduction during the course of one year achieved through a diet intervention with or without aerobic exercise.

"So this program was highly achievable and reproducible. We are not talking about drastic weight loss," said McTiernan.

The researchers measured levels of C-reactive protein, serum amyloid A, interleukin-6, leukocyte and neutrophil in 439 women.

At the end of one year, C-reactive protein reduced by 36.1 percent in the diet-alone group and by 41.7 percent in the diet and exercise group. Interleukin-6 decreased by 23.1 percent in the diet group and 24.3 percent in the diet and exercise group.

McTiernan and colleagues found a mild dose response, as there were greater reductions in these measures among women who lost at least 5 percent of their body weight. They also found that exercise alone, without a dietary weight loss component, had little effect on inflammation markers.

"This study adds to the growing understanding we have about the link between obesity and cancer, and it appears we can affect inflammation directly through nonpharmaceutical means," said McTiernan.
-end-
Follow the AACR on Twitter: @aacr #aacr

Follow the AACR on Facebook: http://www.facebook.com/aacr.org

About the AACR

Founded in 1907, the American Association for Cancer Research (AACR) is the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR's membership includes 34,000 laboratory, translational and clinical researchers; population scientists; other health care professionals; and cancer advocates residing in more than 90 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis and treatment of cancer by annually convening more than 20 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 18,000 attendees. In addition, the AACR publishes seven peer-reviewed scientific journals and a magazine for cancer survivors, patients and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the Scientific Partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration and scientific oversight of individual and team science grants in cancer research that have the potential for patient benefit. The AACR actively communicates with legislators and policymakers about the value of cancer research and related biomedical science in saving lives from cancer.

For more information about the AACR, visit www.AACR.org.

American Association for Cancer Research

Related Obesity Articles:

Obesity is in the eye of the beholder
Doctors have a specific definition of what it means to be overweight or obese, but in the social world, gender, race and generation matter a lot for whether people are judged as 'thin enough' or 'too fat.'
Type 2 diabetes and obesity -- what do we really know?
Social and economic factors have led to a dramatic rise in type 2 diabetes and obesity around the world.
Three in 4 don't know obesity causes cancer
Three out of four (75 percent) people in the UK are unaware of the link between obesity and cancer, according to a new Cancer Research UK report published today.
Obesity on the rise in Indonesia
Obesity is on the rise in Indonesia, one of the largest studies of the double burden of malnutrition in children has revealed.
Obesity rates are not declining in US youth
A clear and significant increase in obesity continued from 1999 through 2014, according to an analysis of data on United States children and adolescents age 2 to 19 years.
How does the environment affect obesity?
Researchers will be examining how agricultural and food processing practices may affect brown fat activity directly or indirectly.
Obesity Day to highlight growing obesity epidemic in Europe
The growing obesity epidemic, which is predicted to affect more than half of all European citizens by 2030, will be the focus of European Obesity Day to be held on May 21.
Understanding obesity from the inside out
Researchers developed a new laboratory method that allowed them to identify GABA as a key player in the complex brain processes that control appetite and metabolism.
Epigenetic switch for obesity
Obesity can sometimes be shut down.
Immunological Aspects of Obesity
This FASEB Conference focuses on the interactions between obesity and immune cells, focusing in particular on how inflammation in various organs influences obesity and obesity-related complications.

Related Obesity Reading:

The Obesity Code: Unlocking the Secrets of Weight Loss
by Dr. Jason Fung (Author), Timothy Noakes (Foreword)

Fung zeroes in on why insulin resistance has become so prevalent and offers specific outside-the-box solutions that have emerged as the key to maximizing health."
—Jimmy Moore, author, Keto Clarity and Cholesterol Clarity


Everything you believe about how to lose weight is wrong. Weight gain and obesity are driven by hormones—in everyone—and only by understanding the effects of insulin and insulin resistance can we achieve lasting weight loss.

In this highly readable and provocative book, Dr. Jason Fung sets out an original, robust theory of obesity... View Details


Obesity: Evaluation and Treatment Essentials, Second Edition
by G. Michael Steelman (Editor), Eric C. Westman (Editor)

Obesity is considered a complex and multifactorial disease. Its treatment, therefore, must also be multimodal and tailored to meet the needs of each patient. Obesity: Evaluation and Treatment Essentials presents a wide spectrum of practical treatment protocols for obesity including exercise, pharmacology, behavior modification, and dietary factors, from the point of view of the practicing physician.

The book includes information about the new pharmacotherapy available for the treatment of obesity. It also includes a chapter on medical treatment of pediatric obesity that... View Details


The Obesity Paradox: When Thinner Means Sicker and Heavier Means Healthier
by Carl J. Lavie M.D. (Author)

Most of us think that longevity hinges on maintaining a normal Body Mass Index. But research conducted over the last decade hit the media in January with explosive news: Overweight and even moderately obese people with certain chronic diseases—from heart disease to cancer— often live longer and fare better than normalweight individuals with the same ailments.

In this groundbreaking book, Carl Lavie, MD, reveals the science behind the obesity paradox and shows us how to achieve maximum health rather than minimum weight. Lavie not only explains how extra fat provides additional fuel... View Details


Obesity: Cultural and Biocultural Perspectives (Studies in Medical Anthropology)
by Alexandra A. Brewis (Author)

In a world now filled with more people who are overweight than underweight, public health and medical perspectives paint obesity as a catastrophic epidemic that threatens to overwhelm health systems and undermine life expectancies globally. In many societies, being obese also creates profound personal suffering because it is so culturally stigmatized. Yet despite loud messages about the health and social costs of being obese, weight gain is a seemingly universal aspect of the modern human condition.

Grounded in a holistic anthropological approach and using a range of ethnographic and... View Details


Practical Manual of Clinical Obesity
by Robert Kushner (Author), Victor Lawrence (Author), Sudhesh Kumar (Author)

This accessible guide to obesity and its clinical management provides clear, didactic, clinically focused guidance for all healthcare professionals involved in the treatment and management of patients with obesity, thus acting as a repository of essential practical knowledge. It is an ideal practical guide for registrars and residents in endocrinology and metabolic disease, as well as all other health professionals who regularly manage obese patients, such as specialist obesity and diabetes nurses, dietitians, and general practitioners with an interest in obesity management. View Details


The Obesity Epidemic: What caused it? How can we stop it?
by Zoe harcombe (Author)

"The Obesity Epidemic: What caused it? How can we stop it?" does what it says in the title - it answers those two critical questions. It takes you on the journey that the author, Zoe Harcombe went on to answer those questions and hopefully it will shock you as much as it shocked her. The starting point must be - when did The Obesity Epidemic start? The graphs and tables show a stunning increase in obesity levels at the turn of the 1980's and obesity literally takes off, like an aeroplane trajectory, from that point onwards. Obesity in the UK, as an example, increases almost 10 fold between... View Details


Textbook of Obesity: Biological, Psychological and Cultural Influences
by Sharon R. Akabas (Editor), Sally Ann Lederman (Editor), Barbara J. Moore (Editor)

Textbook of Obesity is designed to cover all of the essential elements concerning the etiology, prevention and treatment of obesity suitable for students in nutrition, dietetics and health science courses. Providing core knowledge for students is an essential and urgent requirement to ensure that those graduating will be properly equipped to deal with the high prevalence of overweight and obesity, currently affecting almost two-thirds of the population of the USA and with prevalence in much of the rest of the world rapidly catching up.

This landmark text is organized into 5... View Details


Eating Disorders and Obesity, Third Edition: A Comprehensive Handbook
by Kelly D. Brownell (Editor), B. Timothy Walsh (Editor)

Acclaimed for its encyclopedic coverage, this is the only handbook that synthesizes current knowledge and clinical practices in the fields of both eating disorders and obesity. Like the prior editions, the significantly revised third edition features more than 100 concise, focused chapters with lists of key readings in place of extended references. All aspects of eating disorders and obesity are addressed by foremost clinical researchers: classification, causes, consequences, risk factors, and pathophysiology, as well as prevention, treatment, assessment, and diagnosis.
 
New to... View Details


The Obesity Epidemic: Why Diets and Exercise Don't Work―and What Does
by Robyn Toomath (Author)

In a world where charlatans promise to fix the alarming obesity epidemic with a silver-bullet diet or trendy new exercise program, Robyn Toomath, a physician and realist, steps out of the fray to deliver some tough news: it’s really hard to lose weight. Dispelling common myths and telling provocative truths about weight gain―and loss―The Obesity Epidemic is an engaging investigation into the complicated factors that lead to obesity.

While genes certainly play a part, Toomath argues, more people are fat than ever before because most of us consume significantly more... View Details


Obesity: Prevention and Treatment
by James M. Rippe (Editor), Theodore J. Angelopoulos (Editor)

The prevalence of obesity in the United States and the rest of the industrialized world has skyrocketed in the past 20 years. Linked to heart disease, diabetes, hypertension, and metabolic syndrome, it is also the leading cause of osteoarthritis and the second leading cause of cancer. With contributions from leading experts in the field, Obesity: Prevention and Treatment bridges the gap between emerging understanding of the pathophysiology of obesity with concrete clinical applications for physicians and other healthcare workers in all disciplines of medicine.

... View Details

Best Science Podcasts 2018

We have hand picked the best science podcasts for 2018. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

The Big Five
What are the five biggest global challenges we face right now — and what can we do about them? This hour, TED speakers explore some radical solutions to these enduring problems. Guests include geoengineer Tim Kruger, president of the International Rescue Committee David Miliband, political scientist Ian Bremmer, global data analyst Sarah Menker, and historian Rutger Bregman.
Now Playing: Science for the People

#456 Inside a Conservation NGO
This week we take a close look at conservation NGOS: what they do, how they work, and - most importantly - why we need them. We'll be speaking with Shyla Raghav, the Climate Change Lead at Conservation International, about using strategy and policy to tackle climate change. Then we'll speak with Rebecca Shaw, Lead Scientist at the World Wildlife Fund, about how and why you should get involved with conservation initiatives.