Association of polymorphisms of dopamine D2 receptor (DRD2) and dopamine trapnsporter (DAT1) genes with schizoid/avoidant behaviors

May 01, 1997

Previous research has suggested that similar gene variants of both the dopamine D2 receptor gene (DRD2) and the dopamine transporter gene (DAT1) may be associated with a number of addictive behaviors (i.e. alcoholism, substance abuse, and nicotine dependence). In this study of 129 individuals, the authors found an association of the DRD2 A1 allele and Schizoid/Avoidant behaviors (SAB). The severity of the SAB increased with increasing frequency of the DRD2 A1 allele gene pattern. For further information, please contact the corresponding author, Dr. Kenneth Blum, Research Professor, The University of Texas Houston School of Public Health, MPH Program at San Antonio, Texas, USA; Tel: 210-499-0537; FAX: +1 210 490-8634 or +1 210 828-1663.

K Blum, ER Braverman, S Wu, JG Cull, TJH Chen, J Gill, R Wood, A Eisenberg, M Sherman, KR Davis, D Matthews, L Fischer, N Schnautz, W Walsh, AA Pontius, M Zedar, G Kaatz, and DE Comings University of Texas Houston Science Center School of Public Health; Department of Psychiatry, New York University School of Medicine, New York, NY; City of Hope National Medical Center, Duarte, CA; Kantroll, Inc., San Antonio, TX; Chang Jung University, Taiwan; University of Texas Health Science Center, San Antonio; University of North Texas Health Science Center, Fort Worth, TX; Comprehensive Neurobehavioral Systems, Austin, TX; San Marcos Treatment Center, San Marcos, TX; Pfeiffer Treatment Center, Naperville, IL; Massachusetts General Hospital, Harvard Medical School, Boston, MA, and Health and Medical Research Foundation, San Antonio, TX, USA

These articles will be published in the May issue of Molecular Psychiatry, an independent peer-reviewed journal published by Stockton Press/Macmillan Press.

Editor: Julio Licinio, MD - editorial assistant: Rachel Lisman
Bldg. 10/2D46, 10 Center Drive, Bethesda, MD 20892-1284, USA
phone: +1 301 496-6979; FAX: +1 301 402-1561

Publisher: Marija Vukovojac, Stockton Press, phone and FAX: +44 1483 892119
e-mail: 100743.2265@CompuServe.COM

For information on the scientific aspects of the article please contact the authors or the scientist who wrote an independent commentary. Pre-prints of the articles can be obtained from Ms. Rachel Lisman:
phone: +1 301 496-6979; FAX: +1 301 402-1561

Molecular Psychiatry

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