No association between the serotonin transporter gene regulatory region polymorphism and the tridimensional personality questionaire (TPQ) of harm avoidance

May 01, 1997

It was recently reported in Science (1997; 274:1527-1531) that there was an association between anxiety traits and a newly described functional polymorphism in the serotonin transporter transcriptional control region (5-HTTLPR). In the present work, Cloninger's Tridimensional Personality Questionnaire (TPQ) was used to assess personality dimensions such as novelty seeking, harm avoidance, reward dependence, and persistence. The authors conducted a study of 120 normal adult male and female volunteers. They found no relationship between the 5-HTTLPR polymorphism and any of the four TPQ personality dimensions, including harm avoidance, which incorporates many aspects of anxiety and is correlated with NEO-PI-R neuroticism. These findings could not be explained by differences in genotype frequency or by ethnic background (Ashkenazi and non-Ashkenazi). Although lack of association in this study might be disappointing, it is not an unexpected result of repeated investigations designed to confirm initial findings across diverse cultural and ethnic categories. For further information, please contact the corresponding author, Dr. Richard P. Ebstein, at the Research Laboratory, S. Herzog Memorial Hospital, Jerusalem, Israel; Tel: +972-2-5316855; Fax: +972-2-5316855; e-mail:

RP Ebstein, I Gritsenko, L Nemanov, A Frisch, Y Osher, RH Belmaker Research Laboratory, S Herzog Memorial Hospital, Jerusalem, Sackler School of Medicine, Tel-Aviv University, and Ben-Gurion University of the Negev, Beersheva, Israel

These articles will be published in the May issue of Molecular Psychiatry, an independent peer-reviewed journal published by Stockton Press/Macmillan Press.

Editor: Julio Licinio, MD - editorial assistant: Rachel Lisman
Bldg. 10/2D46, 10 Center Drive, Bethesda, MD 20892-1284, USA
phone: +1 301 496-6979; FAX: +1 301 402-1561

Publisher: Marija Vukovojac, Stockton Press, phone and FAX: +44 1483 892119
e-mail: 100743.2265@CompuServe.COM

For information on the scientific aspects of the article please contact the authors or the scientist who wrote an independent commentary. Pre-prints of the articles can be obtained from Ms. Rachel Lisman:
phone: +1 301 496-6979; FAX: +1 301 402-1561

Molecular Psychiatry

Related Aspects Articles from Brightsurf:

Scientists propose immune cocktail therapy to boost cancer-immunity cycle in multiple aspects
A research team led by Prof. TIAN Huayu from the Changchun Institute of Applied Chemistry (CIAC) of the Chinese Academy of Sciences proposed an innovative immune cocktail therapy that combined ICT along with other therapeutic approaches.

Understanding the psychological aspects of the COVID-19 pandemic
Research at SMU to understand the psychological aspects of COVID-19 points to two main areas: message framing and emotion-regulation.

Increasing graduation rates of students of color with more faculty of color
A new analysis published in Public Administration found that student graduation rates improve as more faculty employed by a college or university share sex and race/ethnic identities with students.

Effectiveness of programs to enhance aspects of wisdom
This study combined the results of 57 studies with 7,000 participants to examine how effective are interventions and programs to enhance the social, emotional and spiritual aspects of wisdom.

Lack of transparency in urban sustainability rankings
UPV/EHU researchers have looked at the quality and good methodological practices employed and published in 21 rankings, indexes and similar tools used for classifying and monitoring urban sustainability.

Researchers studying motivational aspects of mindfulness find quality differs by situation
What makes people more or less mindful from one situation to the next?

The problem with promoting 'responsible dog ownership'
Dog welfare campaigns that tell people to be 'responsible owners' don't help to promote behaviour change, a new University of Liverpool report suggests.

Changing partners doesn't change relationship dynamics, study shows
New romances eventually follow patterns similar to old ones, according to U of A relationship researcher who led eight-year study.

Your spending data may reveal aspects of your personality
How you spend your money can signal aspects of your personality, according to research published in Psychological Science, a journal of the Association for Psychological Science.

Passion trumps love for sex in relationships
When women distinguish between sex and the relational and emotional aspects of a relationship, this determines how often couples in long-term relationships have sex.

Read More: Aspects News and Aspects Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to