Using RNA as your guideMay 02, 2005
Pseudouridylation is one of the most abundant forms of post-transcriptional RNA modification in eukaryotes and archaea, and plays a key role in the generation and correct functioning of cellular RNAs. The modifications are made by a complex of proteins directed to target sites by integral non-coding guide RNAs. Drs. Michael and Rebecca Terns and colleagues have effectively reconstituted the archaeal modification guide ribonucleoprotein complex that guides pseudouridylation in vitro in a site-specific manner. This study provides unprecedented insight into the organization and function of pseudouridylation guide RNPs, and Dr. Terns indicates that "this is only the beginning of the gold mine of new information that this system will yield about a complex that is also involved in rRNA processing and the function of telomerase in eukaryotes."
Cold Spring Harbor Laboratory
Related Archaea Articles:
It turns out your skin is crawling with single-celled microorganisms -- and they're not just bacteria.
A team of scientists led by the University of Bristol has provided new insights into the origins of the Archaea, the group of simple cellular organisms that are the ancestors of all complex life.
A new study by has documented the use of CRISPR-Cas9 mediated genome editing in the third domain of life, Archaea, for the first time.
In a new study, published in Nature this week, an international research group led from Uppsala University in Sweden presents the discovery of a group of microbes that provide new insights as to how complex cellular life emerged.
A research team led by Christa Schleper from the University of Vienna succeeded in isolating the first ammonia-oxidizing archaeon from soil: Nitrososphaera viennensis -- the 'spherical ammonia oxidizer from Vienna.' In the current issue of the renowned journal PNAS, the scientists present new results: they were able to detect all proteins that are active during ammonia oxidation -- another important piece of the puzzle for the elucidation of the energy metabolism of Archaea.
Scientists from the Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research have overcome a seeming weakness of global climate models.
The first eukaryote is thought to have arisen when simpler archaea and bacteria joined forces.
UC Berkeley scientists have dramatically expanded the tree of life, which depicts the variety and evolution of life on Earth, to account for thousands of new microscopic life forms discovered over the past 15 years.
They live several kilometers under the surface of the earth, need no light or oxygen and can only be seen in a microscope.
Microorganisms in the sea organize their power supply via tiny power-cables, thus oxidizing the greenhouse gas methane.
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