Early use of statins after coronary syndromes does not reduce risk of heart attack, stroke or death

May 02, 2006

Beginning use of statins within 14 days of acute coronary syndromes (such as heart attack or unstable angina) does not decrease the risk of death, heart attack, or stroke, for up to 4 months, based on a meta-analysis of previously published studies, according to an article in the May 3 issue of JAMA.

Numerous clinical trials and meta-analyses show that long-term therapy with statins reduces the risk of myocardial infarction (MI - heart attack), stroke, and death in patients at varying risks for cardiovascular disease, according to background information in the article. The short-term effects of early treatment with statins in patients after the onset of acute coronary syndrome (ACS, including MI or unstable angina) for these outcomes is unclear.

Matthias Briel, M.D., of the University Hospital Basel, Switzerland and colleagues conducted a meta-analysis of previous randomized controlled trials to determine whether early use of statins within 14 days following the onset of ACS reduces cardiovascular illness and overall death at 1 and 4 months. The researchers identified 12 trials involving 13,024 patients with ACS.

The researchers found that there were no statistically significant risk reductions from early statin therapy for total death, total MI, total stroke, cardiovascular death, fatal or nonfatal MI, or revascularization procedures (percutaneous coronary intervention or coronary artery bypass graft) at 1 month and 4 months of follow-up. The researchers add that serious adverse events associated with early initiation of statins are rare.
-end-
(JAMA. 2006;295:2046-2056. Available pre-embargo to the media at www.jamamedia.org)

Editor's Note: For funding/support and financial disclosure information, please see the JAMA article.

The JAMA Network Journals

Related Heart Attack Articles from Brightsurf:

Top Science Tip Sheet on heart failure, heart muscle cells, heart attack and atrial fibrillation results
Newly discovered pathway may have potential for treating heart failure - New research model helps predict heart muscle cells' impact on heart function after injury - New mass spectrometry approach generates libraries of glycans in human heart tissue - Understanding heart damage after heart attack and treatment may provide clues for prevention - Understanding atrial fibrillation's effects on heart cells may help find treatments - New research may lead to therapy for heart failure caused by ICI cancer medication

Molecular imaging identifies link between heart and kidney inflammation after heart attack
Whole body positron emission tomography (PET) has, for the first time, illustrated the existence of inter-organ communication between the heart and kidneys via the immune system following acute myocardial infarction.

Muscle protein abundant in the heart plays key role in blood clotting during heart attack
A prevalent heart protein known as cardiac myosin, which is released into the body when a person suffers a heart attack, can cause blood to thicken or clot--worsening damage to heart tissue, a new study shows.

New target identified for repairing the heart after heart attack
An immune cell is shown for the first time to be involved in creating the scar that repairs the heart after damage.

Heart cells respond to heart attack and increase the chance of survival
The heart of humans and mice does not completely recover after a heart attack.

A simple method to improve heart-attack repair using stem cell-derived heart muscle cells
The heart cannot regenerate muscle after a heart attack, and this can lead to lethal heart failure.

Mount Sinai discovers placental stem cells that can regenerate heart after heart attack
Study identifies new stem cell type that can significantly improve cardiac function.

Fixing a broken heart: Exploring new ways to heal damage after a heart attack
The days immediately following a heart attack are critical for survivors' longevity and long-term healing of tissue.

Heart patch could limit muscle damage in heart attack aftermath
Guided by computer simulations, an international team of researchers has developed an adhesive patch that can provide support for damaged heart tissue, potentially reducing the stretching of heart muscle that's common after a heart attack.

How the heart sends an SOS signal to bone marrow cells after a heart attack
Exosomes are key to the SOS signal that the heart muscle sends out after a heart attack.

Read More: Heart Attack News and Heart Attack Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.