Nav: Home

New research from Yale and MIT describes bioreactor to support whole lung regeneration

May 03, 2016

New Rochelle, NY, May 3, 2016--An innovative mechanical system that mimics the ventilation and blood flow in the chest cavity, housed in a specialized, sterile bioreactor, can support the growth of engineered whole lungs at human scale. Researchers designed this biomimetic environment to advance toward clinical application of whole lung regeneration for transplant using a patient's own cells, as described in BioResearch Open Access, a peer-reviewed open access journal from Mary Ann Liebert, Inc., publishers. The article is available to download on the BioResearch Open Access website.

Micha Sam Brickman Raredon and coauthors, Yale University (New Haven, CT), MIT (Cambridge, MA), and Raredon Resources, Inc. (Northampton, MA), provide a detailed description of the design and construction of the novel bioreactor system that can accommodate human or pig lungs.

In the article "Biomimetic Culture Reactor for Whole Lung Engineering," the researchers present data from experiments that demonstrate the ability to keep lung tissue alive and functional and to remove the cellular material from an entire porcine lung while it is in the apparatus.

"The new bioreactor design described in this article will be of interest to those in the translational organogenesis and regenerative medicine community," says BioResearch Open Access Editor Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, Scotland. "It begins to address the critical need to develop functional bioreactors suitable for clinical application,"
-end-
Research reported in this publication was supported by the National Institutes of Health Award Number 1U01HL111016-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

About the Journal

BioResearch Open Access is a peer-reviewed open access journal led by Editor-in-Chief Robert Lanza, MD, Chief Scientific Officer, Advanced Cell Technology, Inc. and Editor Jane Taylor, PhD. The Journal provides a new rapid-publication forum for a broad range of scientific topics including molecular and cellular biology, tissue engineering and biomaterials, bioengineering, regenerative medicine, stem cells, gene therapy, systems biology, genetics, biochemistry, virology, microbiology, and neuroscience. All articles are published within 4 weeks of acceptance and are fully open access and posted on PubMed Central. All journal content is available on the BioResearch Open Access website.



About the Publisher


Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many areas of science and biomedical research, including DNA and Cell Biology, Tissue Engineering, Stem Cells and Development, Human Gene Therapy, HGT Methods, and HGT Clinical Development, and AIDS Research and Human Retroviruses. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

Mary Ann Liebert, Inc./Genetic Engineering News

Related Blood Flow Articles:

Blood flow monitor could save lives
A tiny fibre-optic sensor has the potential to save lives in open heart surgery, and even during surgery on pre-term babies.
Changes in blood flow tell heart cells to regenerate
Altered blood flow resulting from heart injury switches on a communication cascade that reprograms heart cells and leads to heart regeneration in zebrafish.
Blood flow command center discovered in the brain
An international team of researchers has discovered a group of cells in the brain that may function as a 'master-controller' for the cardiovascular system, orchestrating the control of blood flow to different parts of the body.
Researchers closer to new Alzheimer's therapy with brain blood flow discovery
By discovering the culprit behind decreased blood flow in the brain of people with Alzheimer's, biomedical engineers at Cornell University have made possible promising new therapies for the disease.
In vitro grafts increase blood flow in infarcted rat hearts
Advances in stem cell research offer hope for treatments that could help patients regrow heart muscle tissue after heart attacks, a key to patients achieving more complete recoveries.
More Blood Flow News and Blood Flow Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Erasing The Stigma
Many of us either cope with mental illness or know someone who does. But we still have a hard time talking about it. This hour, TED speakers explore ways to push past — and even erase — the stigma. Guests include musician and comedian Jordan Raskopoulos, neuroscientist and psychiatrist Thomas Insel, psychiatrist Dixon Chibanda, anxiety and depression researcher Olivia Remes, and entrepreneur Sangu Delle.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...