Nav: Home

Genetic test shows risk for serious adverse reaction to toxic goitre treatment

May 04, 2016

Researchers and doctors at Uppsala University, along with Swedish and international collaboration partners, have found gene variants that predict the risk of a serious adverse reaction to drugs used for the treatment of hyperthyroidism. The results are published in The Lancet Diabetes & Endocrinology.

Adverse drugs reactions are a leading cause of admission to hospital. Genetic variation is believed to contribute to a majority of serious immune-mediated adverse drug reactions. These reactions are being studied by the Swedegene project led by Pär Hallberg and Mia Wadelius at the Department of Medical Sciences, Clinical Pharmacology at Uppsala University, in collaboration with the Swedish Medical Products Agency, Karolinska Institutet and a large number of international researchers and doctors. The aim is to develop tests to predict patients at high risk of suffering side-effects so that they can be offered other treatment. In the long run, this could lead to safer and more individualised treatment.

'Our long-term work has now started to yield results. We systematically collect samples from patients with serious side-effects in Sweden and we work in collaboration with other countries. Thanks to the participation of patients in Sweden, Spain, France and Germany, we can now predict the risk of suffering a serious side-effect of medication against toxic goitre,' says Pär Hallberg, chief physician and associate professor at Clinical Chemistry and Pharmacology, Uppsala University Hospital (Akademiska sjukhuset) who also set up the European Drug Induced Agranulocytosis Consortium (EUDAC).

'Some patients treated with medication for hyperthyroidism, such as thiamazole (methimazole), carbimazole or propylthiouracil, react with agranulocytosis which is a lack of white blood cells that suppresses the immune system. We've shown that certain immune genes increase the risk of agranulocytosis 750 times in Europeans. This gives us an opportunity to individualise treatment using genetic testing and thus avoid an unnecessary adverse reaction,' says Mia Wadelius, senior physician and lecturer at Clinical Chemistry and Pharmacology, Uppsala University Hospital who is the lead author of the article.

'These discoveries confirm the value of working with Swedegene which began in 2008. We have the infrastructure and the ambition to bring in many more patients who suffer from other side-effects. In addition to our present article, we already have a number of promising results that will be published,' says Pär Hallberg.
-end-
More information about Swedegene. http://www.swedegene.se/index.php/in-english

EUDAC is a network of collaborators from Uppsala University, Medical Products Agency and Karolinska Institutet in Sweden, and amongst others Universitat Autònoma de Barcelona, Universidad de Valladolid, Universidad de Málaga, Hospital General de Catalunya and Consejo Superior de Investigaciones Científicas in Granada, Spain, l'Université de Toulouse in France, Charité - Universitätsmedizin Berlin in Germany, and King's College London in the UK.

Reference

Hallberg P, Eriksson N, Ibañez L, Bondon-Guitton E, Kreutz R, Carvajal A, Lucena M, Sancho Ponce E, Sainz Gill M, Douros A, Lapeyre-Mestre M, Montastruc JL, Ruiz-Nuñes J, Stephens CM, Martin J, Axelsson T, Yue QY, Magnusson PK, Wadelius M, on behalf of EuDAC. Genetic variants associated with antithyroid drug-induced agranulocytosis: a genome-wide association study in a European population. Lancet Diabetes Endocrinol. Epub 2016 May 3 2016.

Uppsala University

Related Immune System Articles:

Using the immune system as a defence against cancer
Research published today in the British Journal of Cancer has found that a naturally occurring molecule and a component of the immune system that can successfully target and kill cancer cells, can also encourage immunity against cancer resurgence.
First impressions go a long way in the immune system
An algorithm that predicts the immune response to a pathogen could lead to early diagnosis for such diseases as tuberculosis
Filming how our immune system kill bacteria
To kill bacteria in the blood, our immune system relies on nanomachines that can open deadly holes in their targets.
Putting the break on our immune system's response
Researchers have discovered how a tiny molecule known as miR-132 acts as a 'handbrake' on our immune system -- helping us fight infection.
Decoding the human immune system
For the first time ever, researchers are comprehensively sequencing the human immune system, which is billions of times larger than the human genome.
More Immune System News and Immune System Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Rethinking Anger
Anger is universal and complex: it can be quiet, festering, justified, vengeful, and destructive. This hour, TED speakers explore the many sides of anger, why we need it, and who's allowed to feel it. Guests include psychologists Ryan Martin and Russell Kolts, writer Soraya Chemaly, former talk radio host Lisa Fritsch, and business professor Dan Moshavi.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...