MR imaging and new contrast agent effective in diagnosing testicular cancer spread

May 05, 2003

MR imaging plus a new contrast agent (ferumoxtran-10, Combidex) is dramatically better than current techniques in determining if testicular cancer has spread, a new study indicates. The contrast agent is awaiting Food and Drug Administration approval.

Sixteen patients with proven testicular cancer had an MR examination without the new contrast media and a separate MR examination 24 hours after the contrast media had been injected to determine if their disease had spread into their lymph nodes, says Mukesh Harisinghani, MD, a radiologist at Massachusetts General Hospital in Boston. The images were reviewed by two radiologists who indicated whether they believed the lymph nodes were benign or malignant. "The signal intensity of the lymph nodes, that is how bright the lymph nodes looked on the MR image, changed from light (before the contrast media was given) to dark (after the contrast media) for benign disease," says Dr. Harisinghani. The signal intensity was relatively unchanged for malignant lymph nodes, he says.

The radiologist's diagnosis was compared to the results of biopsy of the lymph nodes, and the MR images were 92 percent accurate in identifying malignant disease, says Dr. Harisinghani

"This new method of diagnosing metastases in testicular cancer patients is substantially better than using CT to image the lymph nodes and measure their size. While larger lymph nodes are suspicious, lymph nodes that haven't grown in size can also be hiding malignant disease," he says.

When this contrast agent is approved by the Food and Drug Administration it will change the way we evaluate these patients, adds Dr. Harisinghani.
Dr. Harisinghani will present the study May 5 during the American Roentgen Ray Society Annual Meeting in San Diego.

Additional Contact Information:
Danica Laub (703) 858-4332
Keri Sperry (703) 858-4306
Press Room (619) 525-6536 (May 5-8)

American College of Radiology

Related Lymph Nodes Articles from Brightsurf:

How to prevent the spread of tumor cells via the lymph vessels
Scientists from the German Cancer Research Center and the Mannheim Medical Faculty of the University of Heidelberg identified a new way to block the dangerous spread of tumor cells via lymphatic vessels.

Photoacoustic microscopy for identifying sentinel lymph nodes of breast cancer
Tumor metastatic sentinel lymph nodes is difficult to distinguish from normal or inflamed lymph nodes (Inf-LN).

Pigs grow new liver in lymph nodes, study shows
Hepatocytes -- the chief functional cells of the liver - are natural regenerators, and the lymph nodes serve as a nurturing place where they can multiply.

The secret of lymph: How lymph nodes help cancer cells spread
For decades, physicians have known that many kinds of cancer cells often spread first to lymph nodes before traveling to distant organs through the bloodstream.

Newly identified gut cells nurture lymph capillaries
IBS research team has identified new subsets of gut connective cells, which are crucial for lymphatic growth.The findings imply a crucial link between the physiology of intestinal environment and biological interactions between cell types.

Pathological regression of lymph nodes better predicts esophageal cancer survival
A team of researchers led by Osaka University established a new pathological grading system to evaluate the therapeutic effect of neoadjuvant chemotherapy (NAC) for metastatic lymph nodes (LNs) removed in esophageal cancer (EC) surgery, demonstrating that the system predicts recurrence and prognosis in EC patients better than conventional systems.

Unveiling how lymph nodes regulate immune response
The Hippo pathway keeps lymph nodes' development healthy. If impaired, lymph nodes become full of fat cells or fibrosis develops.

S1P molecule regulates dendritic cell localization and vascular integrity in lymph nodes
Researchers found that HEVs, which were deficient for the S1P-transporter Spinster-homologue-2, were unable to attract dendritic cells in order to trigger LTβr-signaling through cell-cell contact with HEVs.

Nanoparticle therapy targets lymph node metastases
Metastasis, in which cancer cells break free from the primary tumor and form tumors at other sites, worsens the prognosis for many cancer patients.

Lymph nodes can predict survival in patients with esophageal cancer
It is difficult for physicians to estimate recurrence and survival in patients with esophageal cancer.

Read More: Lymph Nodes News and Lymph Nodes Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to