Trial questions benefits of organic nitrates for bone health

May 06, 2020

Several clinical trials have reported beneficial effects of organic nitrates on bone health, which could lead to a reduced risk of fractures. Some of these trials have been retracted because of scientific misconduct; however. A new study published in the Journal of Bone and Mineral Research found that organic nitrates do not have clinically relevant effects on bone mineral density or bone turnover in postmenopausal women, and the medications caused significant side effects.

The study was a double-blind, randomized, placebo-controlled trial of three different nitrate preparations and two different doses in postmenopausal women with bone loss. There were no differences in changes in bone mineral density or bone turnover markers between organic nitrate treatment and placebo.

The results call into question the validity of previous clinical research reporting large positive effects of nitrates on bone health.

"Based on previous clinical trials, we had high hopes that treatment with nitrates might be a safe and highly effective treatment for preventing age-related bone loss and fractures. We assessed several different doses and forms of nitrates and our results show clearly that no preparation or dose had any effect on bone density or bone turnover, but they did cause significant side-effects for women," said lead author Mark Bolland, MBChB, PhD, of the University of Auckland, in New Zealand. "Sadly, this research area has recently had several studies with strongly positive results retracted because of scientific misconduct. We think our paper provides closure, with fairly definitive evidence that nitrates do not affect surrogate measures of bone health and thus there is no reason to think they would prevent fractures."
-end-


Wiley

Related Clinical Trials Articles from Brightsurf:

Nearly 1 in 5 cancer patients less likely to enroll in clinical trials during pandemic
A significant portion of cancer patients may be less likely to enroll in a clinical trial due to the ongoing coronavirus pandemic.

COVID-19 clinical trials lack diversity
Despite disproportionately higher rates of COVID-19 infection, hospitalization and death among people of color, minority groups are significantly underrepresented in COVID-19 clinical trials.

Why we should trust registered clinical trials
In a time when we have to rely on clinical trials for COVID-19 drugs and vaccines, a new study brings good news about the credibility of registered clinical trials.

Inclusion of children in clinical trials of treatments for COVID-19
This Viewpoint discusses the exclusion of children from coronavirus disease 2019 (COVID-19) clinical trials and why that could harm treatment options for children.

Review evaluates how AI could boost the success of clinical trials
In a review publishing July 17, 2019 in the journal Trends in Pharmacological Sciences, researchers examined how artificial intelligence (AI) could affect drug development in the coming decade.

Kidney patients are neglected in clinical trials
The exclusion of patients with kidney diseases from clinical trials remains an unsolved problem that hinders optimal care of these patients.

Clinical trials beginning for possible preeclampsia treatment
For over 20 years, a team of researchers at Lund University has worked on developing a drug against preeclampsia -- a serious disorder which annually affects around 9 million pregnant women worldwide and is one of the main causes of death in both mothers and unborn babies.

Underenrollment in clinical trials: Patients not the problem
The authors of the study published this month in the Journal of Clinical Oncology investigated why many cancer clinical trials fail to enroll enough patients.

When designing clinical trials for huntington's disease, first ask the experts
Progress in understanding the genetic mutation responsible for Huntington's disease (HD) and at least some molecular underpinnings of the disease has resulted in a new era of clinical testing of potential treatments.

New ALS therapy in clinical trials
New research led by Washington University School of Medicine in St.

Read More: Clinical Trials News and Clinical Trials Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.