Max daily OTC dose of acetaminophen shows efficacy comparable to Rx doses of naproxen for OA pain

May 07, 2004

VANCOUVER, BC (May 7, 2004)--Researchers today announced new clinical evidence showing that long-term use of maximum recommended over-the-counter (OTC) daily doses of acetaminophen (APAP) provide efficacy comparable to prescription doses of naproxen (NAP) for the management of mild-to-moderate osteoarthritis (OA) pain of the hip or knee.

Preliminary analyses of the multicenter, randomized, double-blind, parallel-group, comparative study involving 551 patients aged 40 to 75 years old with mild-to-moderate OA of the hip or knee were presented during the 2nd Joint Scientific Meeting of the American Pain Society and the Canadian Pain Society. Patients in the APAP-treated group (n=276) received 4000mg per day, while those in the NAP group (n=275) received 750 mg per day. All patients were evaluated at one-, three-, and six-month intervals for pain, stiffness, and physical function using the WOMAC™* subscale for pain.

"Even out to six months, our analyses showed no statistical differences between the efficacy of acetaminophen and naproxen for the management of osteoarthritis pain of the hip and knee," said Dr. Anthony Temple, VP Medical Affairs, McNeil Consumer & Specialty Pharmaceuticals. "These results indicate that acetaminophen is as effective as prescription doses of naproxen for the pain of arthritis when administered for up to 6 months under the care and observation of the physician."
-end-
*Western Ontario and McMaster Universities osteoarthritis index: a standard methodology to measure osteoarthritis pain relief.

About Osteoarthritis
Osteoarthritis is the most common form of arthritis in the United States, affecting more than 20 million Americans. Joint pain and stiffness due to OA results from the breakdown of cartilage in joints. The most commonly affected areas affected by OA are the fingers, knees, hips, and spine. Other joints affected less frequently include the wrists, elbows, shoulders, and ankles.

The American College of Rheumatology's "Recommendations for the Medical Management of Osteoarthritis of the Hip and Knee: 2000 Update" urge OA sufferers to begin treatment with non-medical remedies such as exercise and weight control. Acetaminophen is listed as a first-line medical treatment for osteoarthritis.

The American College of Rheumatology is an independent, professional medical and scientific society that does not guarantee, warrant or endorse any commercial product or service.

Jitsu Public Relations

Related Pain Articles from Brightsurf:

Pain researchers get a common language to describe pain
Pain researchers around the world have agreed to classify pain in the mouth, jaw and face according to the same system.

It's not just a pain in the head -- facial pain can be a symptom of headaches too
A new study finds that up to 10% of people with headaches also have facial pain.

New opioid speeds up recovery without increasing pain sensitivity or risk of chronic pain
A new type of non-addictive opioid developed by researchers at Tulane University and the Southeast Louisiana Veterans Health Care System accelerates recovery time from pain compared to morphine without increasing pain sensitivity, according to a new study published in the Journal of Neuroinflammation.

The insular cortex processes pain and drives learning from pain
Neuroscientists at EPFL have discovered an area of the brain, the insular cortex, that processes painful experiences and thereby drives learning from aversive events.

Pain, pain go away: new tools improve students' experience of school-based vaccines
Researchers at the University of Toronto and The Hospital for Sick Children (SickKids) have teamed up with educators, public health practitioners and grade seven students in Ontario to develop and implement a new approach to delivering school-based vaccines that improves student experience.

Pain sensitization increases risk of persistent knee pain
Becoming more sensitive to pain, or pain sensitization, is an important risk factor for developing persistent knee pain in osteoarthritis (OA), according to a new study by researchers from the Université de Montréal (UdeM) School of Rehabilitation and Hôpital Maisonneuve Rosemont Research Centre (CRHMR) in collaboration with researchers at Boston University School of Medicine (BUSM).

Becoming more sensitive to pain increases the risk of knee pain not going away
A new study by researchers in Montreal and Boston looks at the role that pain plays in osteoarthritis, a disease that affects over 300 million adults worldwide.

Pain disruption therapy treats source of chronic back pain
People with treatment-resistant back pain may get significant and lasting relief with dorsal root ganglion (DRG) stimulation therapy, an innovative treatment that short-circuits pain, suggests a study presented at the ANESTHESIOLOGY® 2018 annual meeting.

Sugar pills relieve pain for chronic pain patients
Someday doctors may prescribe sugar pills for certain chronic pain patients based on their brain anatomy and psychology.

Peripheral nerve block provides some with long-lasting pain relief for severe facial pain
A new study has shown that use of peripheral nerve blocks in the treatment of Trigeminal Neuralgia (TGN) may produce long-term pain relief.

Read More: Pain News and Pain Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.