How does insulin-like growth factor I protect liver function?

May 07, 2008

IGF-I has been shown to exert a mitochondrial protection in experimental cirrhosis leading to reduce caspase activation and apoptosis and increasing ATP production.

The study, performed by a team led by Dra. Castilla de Cortázar Larrea, is described in a research article to be published on May 7, 2008 in the World Journal of Gastroenterology.

IGF-I is an anabolic hormone produced mainly in the liver in response to growth hormone (GH) stimulation. In cirrhosis the reduction of receptors for GH in hepatocytes and the diminished synthesis ability of the hepatic parenchyma cause a progressive fall in serum IGF-I levels. The mechanisms of IGF-I activities regarding the improvement of liver function and fibrosis is not fully understood.

Mitochondria are a major source of reactive oxygen species (ROS) under physiologic conditions. Mitochondria are particularly sensitive to damage induced by ROS in the pathogenesis of disease. Recently, a large number of studies have associated mitochondrial dysfunction caused by ROS to both accidental cell death (necrosis) and programmed cell death (apoptosis).

The biochemical results in this series showed an improvement of liver function tests and a reduction of fibrosis and liver oxidative products were also observed in the animals treated with IGF.

MMP in state 3 and 4 was significantly decreased in the cirrhosis animals and was restored after IGF-I treatment. Mitochondria from untreated cirrhotic rats showed a significant increase of ROS generation as and cirrhotic rats treated with IGF-I. ATPase activity declined in untreated cirrhotic rats.The number of TUNEL-positive hepatocytes was significant increased in untreated cirrhotic group. IGF-I treatment reduced apoptosis in hepatocytes. Westen blotting for fragment-17 of caspasa 3 showed a significant increase of caspase 3 activation in untreated cirrhotic rats. However a notable reduction in the expression of this fragment was observed in cirrhotic animals treated with IGF-I.

In the view of the authors, this work provides new evidence of the beneficial effect of IGF-I supplementation in experimental liver cirrhosis and experimental basis for further studies at exploring the potential of IGF-I in the treatment of human cirrhosis.

World Journal of Gastroenterology

Related Cirrhosis Articles from Brightsurf:

Researchers discover gene that could decrease likelihood of developing alcoholic cirrhosis
Researchers at Indiana University School of Medicine are learning more about how a person's genes play a role in the possibility they'll suffer from alcoholic cirrhosis with the discovery of a gene that could make the disease less likely.

When liver cirrhosis is deadly
A study by an international team of researchers headed by Professor Jonel Trebicka from the Frankfurt University Hospital and funded by the foundation EF Clif, has discovered which patients are particularly at risk for acute-on-chronic liver failure.

Blood tests can predict the risk of liver cirrhosis
Repeated measurements of the biomarker FIB-4 in the blood every few years can predict the risk of developing severe liver disease, according to a new study from Karolinska Institutet in Sweden published in the Journal of Hepatology.

Universal gut microbiome-derived signature predicts cirrhosis
UC San Diego School of Medicine researchers report that stool microbiomes of NAFLD patients are distinct enough to potentially be used to accurately predict which persons with NAFLD are at greatest risk for having cirrhosis.

Strength training benefits patients with cirrhosis
Three hours of weekly strength training combined with protein supplements leads to both bigger and stronger muscles in patients with cirrhosis.

Women are not more likely to die of cirrhosis than men, despite fewer liver transplants
Prior studies suggested women might have higher mortality of cirrhosis of the liver than men.

Movement toward a poop test for liver cirrhosis
In a study of people with nonalcoholic fatty liver disease and their twins and other close relatives, UC San Diego researchers were able to diagnose liver cirrhosis simply by analyzing a person's stool microbes.

Gum disease treatment may improve symptoms in cirrhosis patients
Routine oral care to treat gum disease (periodontitis) may play a role in reducing inflammation and toxins in the blood (endotoxemia) and improving cognitive function in people with liver cirrhosis.

Alcohol-related cirrhosis deaths skyrocket in young adults
Liver disease deaths jumped by 65 percent in the United States, from 1999-2016, disproportionately affecting adults ages 25-34.

Researchers find a promising new approach for treating liver cirrhosis
In a study in The American Journal of Pathology, investigators report that treatment with aleglitazar, a dual peroxisome proliferator-activated receptor-alpha/gamma (PPARα/γ) agonist, reduced inflammation, vasoconstriction, angiogenesis, mucosal disruption, and tumor necrosis factor (TNF)-α overproduction in cirrhotic rats with PH.

Read More: Cirrhosis News and Cirrhosis Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to