Nav: Home

Kidney cells from amniotic fluid obtained from cesarean section at delivery

May 07, 2018

Amniotic fluid, the liquid surrounding the fetus, can be routinely obtained without harming the mother or the baby. Previously, Prof. Dr. Adjaye's team and others demonstrated that amniotic fluid contains mesenchymal stem cells with great differentiation and regenerative potential. Importantly, amniotic fluid stem cells are immune privileged, non-carcinogenic and their potential clinical applications such as cell-replacement therapies to treat bone defects, ischemic stroke, bladder dysfunction and pulmonary disease have been described. However, the origin of amniotic fluid stem cells has been enigmatic.

A collaborative study between the Institute for Stem Cell Research and Regenerative Medicine (Prof. Dr. James Adjaye), the Department of Obstetrics and Gynaecology (Prof. Dr. med. Tanja Fehm) from the Medical Faculty of Heinrich Heine University Düsseldorf-Germany and the Institute for Women's Health, Maternal and Fetal Medicine Department (Dr. Pascale V. Guillot)- University College London, published in the journal- Stem Cell Research and Therapy shows for the first time that human amniotic fluid contains mesenchymal stem cells of kidney origin.

The numbers of these cells increased with gestational time- meaning amniotic fluid obtained during delivery had the highest number simply because of the increased volume of amniotic fluid (composed of fetal urine) bathing the fetus at this stage.

Lead authors- Md Shaifur Rahman and Lucas-Sebastian Spitzhorn state-"the kidney-related features of amniotic fluid stem cells are of high interest as a promising cell source for research on nephrogenesis, modelling kidney-related diseases, nephrotoxicity testing and drug screening".

The derivation of 3D-kidney organoids directly from these cells without the need of induced pluripotent stem cells or renal cells cultured from kidney biopsies will add valuable insights into how the kidney develops.

Prof. Dr. Adjaye senior author, concludes: "Our ongoing research on renal stem cells isolated directly from urine, combined with molecular biology and bioinformatic analysis of the genes expressed in these cells enabled us to define these cells as originating from the kidney. At present kidney dialysis and kidney transplantation for managing kidney diseases are limited due to the shortage of compatible donated organs and high associated costs. In view of this, amniotic fluid should be regarded comparably with cordblood as valuable sources of fetal stem cells with regenerative potential and useful for therapeutic applications."
-end-
Rahman MS, Spitzhorn LS, Wruck W, Hagenbeck C, Balan P, Graffmann N, Bohndorf M, Ncube A, Guillot PV, Fehm T, Adjaye J. The presence of human mesenchymal stem cells of renal origin in amniotic fluid increases with gestational time. Stem Cell Res Ther. 2018 Apr 25;9(1):113. doi: 10.1186/s13287-018-0864-7. PubMed PMID: 29695308.

Heinrich-Heine University Duesseldorf

Related Mesenchymal Stem Cells Articles:

A protein that stem cells require could be a target in killing breast cancer cells
Researchers have identified a protein that must be present in order for mammary stem cells to perform their normal functions.
Approaching a decades-old goal: Making blood stem cells from patients' own cells
Researchers at Boston Children's Hospital have, for the first time, generated blood-forming stem cells in the lab using pluripotent stem cells, which can make virtually every cell type in the body.
Mutations in bone cells can drive leukemia in neighboring stem cells
DNA mutations in bone cells that support blood development can drive leukemia formation in nearby blood stem cells.
Scientists take aging cardiac stem cells out of semiretirement to improve stem cell therapy
With age, the chromosomes of our cardiac stem cells compress as they move into a state of safe, semiretirement.
Stem cell scientists discover genetic switch to increase supply of stem cells from cord blood
International stem cell scientists, co-led in Canada by Dr. John Dick and in the Netherlands by Dr.
Does freeze-thawing and IV delivery affect the therapeutic potential of mesenchymal stromal cells?
Before the therapeutic potential of using human tissue-derived mesenchymal stromal cells (MSC) to treat immune and degenerative diseases can be fully determined, the effects of freeze-thawing and intravenous delivery on MSC function must be understood.
Mount Sinai researchers report insights into blood stem cells from engineered stem cells
Building upon previous work, researchers at the Icahn School of Medicine at Mount Sinai have identified a precursor cell in the placenta and embryo of mice that can be matured in the lab to make hematopoietic stem/progenitor cells
Gene family turns cancer cells into aggressive stem cells that keep growing
An examination of 130 gene expression studies in 10 solid cancers has found that when any of four related genes is overexpressed, patients have much worse outcomes, including reduced survival.
UNC researchers find new way to force stem cells to become bone cells
Imagine you have a bone injury but you heal slowly.

Related Mesenchymal Stem Cells Reading:

MSC (Mesenchymal Stem Cells): Clinical Evidence Leading Medicine's Next Frontier
by PA, PhD Neil H Riordan (Author), PhD Thomas Ichim (Author), Neil Riordan (Contributor)

MSC is a first-of-its-kind publication spanning more than 50 years of research and clinical trials. The authors have carefully outlined and summarized key publications drawing from more than 800 unique references, reviewing mesenchymal stem cell treatment for 44 different medical conditions. They expertly break down the rationale, treatment delivery methods, efficacy, toxicity, and results of prominent clinical trials. View Details


Stem Cell Therapy: A Rising Tide: How Stem Cells Are Disrupting Medicine and Transforming Lives
by Neil H Riordan (Author)

Stem cells are the repair cells of your body.  When there aren’t enough of them, or they aren’t working properly, chronic diseases can manifest and persist. From industry leaders, sport stars, and Hollywood icons to thousands of everyday, ordinary people, stem cell therapy has helped when standard medicine failed. Many of them had lost hope. These are their stories.

Neil H Riordan, author of MSC: Clinical Evidence Leading Medicine’s Next Frontier, the definitive textbook on clinical stem cell therapy, brings you an easy-to-read book about how and why stem cells work,... View Details


A Buyer's Guide to Stem Cell Therapies: Safely Choose the Right Regenerative Treatment for You

The current array of "stem cell" therapies has been called the new wild west of medicine. Between fraudulent advertising and confusing science, it's no wonder that even doctors are unsure of what to think about stem cell treatments. This book aims to educate lay people who may be interested in stem cell or other regenerative treatments as to what options are currently available, both at home and abroad, and what science exists to support their use. View Details


Mesenchymal Stem Cells: Methods and Protocols (Methods in Molecular Biology)
by Darwin J. Prockop (Editor), Donald G. Phinney (Editor), Bruce A. Bunnell (Editor)

For over forty years, mesenchymal stem cells (MSCs) have been scrutinized and studied, garnering much attention due to their broad therapeutic efficacy. In this essential book, leaders in the field were assembled to contribute detailed methodologies for the isolation and characterization of human and rodent MSCs. Cutting edge and easy to use, this book is the perfect resource for scientists attempting to pursue this important and ever-developing field of research.

View Details


Mesenchymal Stem Cells: Methods and Protocols (Methods in Molecular Biology)
by Massimiliano Gnecchi (Editor)

This volume aims to outline the current status of the Mesenchymal Stem Cells(MSC) field in regenerative medicine and to propose clear and reproducible protocols to better define the identity, function and use of these cells that are today, more than ever, “under the spotlight”. Mesenchymal Stem Cells: Methods and Protocols, Second Edition is organized into four sections. The first guides the reader through a series of state-of-the-art reviews summarizing the use of MSC for the treatment of various diseases. The other three sections are a collection of methodological... View Details


Exosomes, Stem Cells and MicroRNA: Aging, Cancer and Age Related Disorders (Advances in Experimental Medicine and Biology)
by Karl L. Mettinger (Editor), Pranela Rameshwar (Editor), Vinod Kumar (Editor)

This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and... View Details


Mesenchymal Stem Cell Derived Exosomes: The Potential for Translational Nanomedicine
by Yaoliang Tang (Author), Buddhadeb Dawn (Author)

Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and... View Details


Mesenchymal Stem Cells and Craniofacial Regeneration
by Jing Wang (Author), Yunfeng Lin (Editor)

This monograph provides a current and in-depth review of scholarly information about mesenchymal stem cells and their application in the craniofacial region of the human body. Chapters in this volume cover biological and conceptual information about mesenchymal stem cells, induced pluripotent stem cells, craniofacial regeneration, new methods of scaffold fabrication, tooth regeneration and three-dimensional printing in dentistry. The book is suitable for clinicians and cell biologists aiming to gain a better understanding of the promising field of craniofacial regenerative medicine. View Details


Mesenchymal Stem Cells and Skeletal Regeneration
by Peter Giannoudis (Author), Elena Jones (Author), Xuebin Yang (Author), Dennis Mcgonagle (Author)

This book covers our current understanding of the role of mesenchymal stem cells (MSCs) and other mesenchymal progenitors in skeletal regeneration, encompassing bone, cartilage and whole joint regeneration. The expansion reflects developments in the field to include data on the use of MSCs in drug development, growth factors, scaffolds and biomechanical manipulations for skeletal trauma and diseases, including osteoporosis and arthritis.

Written for an audience of clinicians and young researchers who are exposed to MSCs in their work, this work summarizes recent findings pertaining... View Details


Mesenchymal Stem Cell Assays and Applications (Methods in Molecular Biology)
by Mohan C Vemuri (Editor), Lucas G. Chase (Editor), Mahendra S. Rao (Editor)

Mesenchymal Stem Cells have seen an unprecedented level of interest in the last decade, primarily due to their relative ease of isolation, the large numbers of cells present in the adult, and the ability to propagate these cells in culture. In Mesenchymal Stem Cell Assays and Applications, expert researchers from across the globe explore the latest techniques to propagate, characterize, and engineer this special cell type. Chapters outline a set of protocols and assays used by leading investigators in the field, providing standards that can be applied by all researchers to the population of... View Details

Best Science Podcasts 2018

We have hand picked the best science podcasts for 2018. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Attention Please
In an age of constant information and infinite distractions, how can we pay more attention to our ... attention? This hour, TED speakers explore the battle for our awareness during the digital age. Guests include sociologist Zeynep Tufekci, podcast host Manoush Zomorodi, neuroscientist Amishi Jha, designer Tristan Harris, and computer scientist Jaron Lanier.
Now Playing: Science for the People

#475 Mother Nature is Trying to Kill You (Rebroadcast)
This week, we're learning how deadly and delightful our planet and its ecosystem can be. We're joined by biologist Dan Riskin, co-host of Discovery Canada's Daily Planet, to talk about his book "Mother Nature Is Trying to Kill You: a Lively Tour Through the Dark Side of the Natural World." And we'll talk to astronomer and author Phil Plait about Science Getaways, his company that offers educational vacation experiences for science lovers.