Nav: Home

MUSC Hollings awarded $8.9 million to study sphingolipid signaling

May 09, 2016

The Medical University of South Carolina's (MUSC) Hollings Cancer Center received an $8.9 million grant from the National Cancer Institute designed to foster collaboration across clinical and laboratory research for the study of signaling in sphingolipids, a class of lipids known to be involved in the growth of solid tumor cancers.

The grant includes three projects, including a Phase II clinical trial of a new therapy for the treatment of advanced hepatocellular carcinoma (HCC), the most common primary malignant cancer of the liver and one that experiences one of the highest mortality rates among cancers. Currently, there is only one approved therapy for HCC. The five-year survival rate for patients with liver cancer is 17 percent.

The program project grant will bring together over 20 cancer scientists at the Hollings Cancer Center with a goal of elucidating the explicit roles of lipid signaling mechanisms which are thought to regulate cancer cell proliferation, resistance to apoptosis (cell death), and metastasis in solid tumors (when cancer spreads from its primary site to other parts of the body). Utilizing mechanistic information gained from these studies, the Hollings-based scientific team will develop new therapeutic strategies not only targeted for liver cancer but with applicability to other solid tumors, such as prostate and urinary (bladder/kidney) cancers.

Besim Ogretmen, Ph.D., Endowed Chair in Lipidomics & Drug Discovery in the SmartState® Center for Lipidomics, Pathobiology and Therapy and professor of Biochemistry & Molecular Biology at MUSC, will oversee the program as principal investigator.

"We are excited about the opportunities in this large, team-based program to share information from laboratory research over into clinical applications, and then take information learned from the clinical applications back into the lab," said Ogretmen. "Through a collaborative effort, our goal is to provide cancer patients the very best care based on the latest cutting-edge research."

In addition to his role as principal investigator, Ogretmen will lead a project designed to study how lipid signaling is involved in tumor metastasis in solid tumor cancers, increasing knowledge regarding inhibiting tumor metastasis and working to identify biomarkers to detect disease earlier.

A second project area will study how cancer cells become resistant to radiation therapy, working to improve response to radiation and chemotherapy. This study, led by co-project leaders Christina Voelkel-Johnson, Ph.D., and James Norris, Ph.D., will primarily focus on prostate cancer, but will have applicability to all solid tumors.

Carolyn D. Britten, M.D., chief of the Division of Hematology/Oncology in the Department of Medicine at MUSC and Associate Director for Clinical Investigations at the MUSC Hollings Cancer Center, will act as principal investigator for the Phase II clinical trial embedded in the third project. The Phase II trial, expected to commence at MUSC in the third quarter of 2016, is intended to evaluate the efficacy and safety of YELIVA™ (ABC294640) as a second-line monotherapy in patients with advanced HCC. YELIVA™ is a proprietary, first-in-class, orally-administered sphingosine kinase-2 (SK2) selective inhibitor. The study will enroll patients who have experienced tumor progression following treatment with first-line single-agent sorafenib (Nexavar®). The SK2 selective inhibitor was developed by Charles Smith, Ph.D., while at MUSC and later sold to RedHill Biopharma. Smith is currently on faculty at Penn State University and will be a co-principal investigator on this trial. RedHill Biopharma will provide additional funding for this area of the project.

As the principal investigator for this overall grant, Ogretmen brings experience as an internationally renowned investigator with a strong scientific track record in the field of lipid signaling and cancer. He has made significant contributions to the fields of cancer and aging biology at a mechanistic level through his pioneering work on the regulation of telomerase by the bioactive sphingolipid ceramide.

"Dr. Ogretmen's work is distinct in that he not only focuses on basic molecular mechanisms but also demonstrates the significance of his findings in human diseases with a keen interest toward therapeutic development. His leadership on this multi-project program is a reflection of this strength and focus, representing a blend of basic and translational research," commented Philip H. Howe, Ph.D., professor and chair, MUSC Department of Biochemistry & Molecular Biology, Hans & Helen Koebig Chair in Oncology.
About Hollings Cancer Center

The Hollings Cancer Center at the Medical University of South Carolina is a National Cancer Institute-designated cancer center and the largest academic-based cancer research program in South Carolina. The cancer center is comprised of more than 120 faculty cancer scientists with an annual research funding portfolio of $44 million and a dedication to reducing the cancer burden in South Carolina. Hollings offers state-of-the-art diagnostic capabilities, therapies and surgical techniques within multidisciplinary clinics that include surgeons, medical oncologists, radiation therapists, radiologists, pathologists, psychologists and other specialists equipped for the full range of cancer care, including more than 200 clinical trials. For more information, visit

Medical University of South Carolina

Related Prostate Cancer Articles:

The Lancet: Prostate cancer study finds molecular imaging could transform management of patients with aggressive cancer
Results from a randomised controlled trial involving 300 prostate cancer patients find that a molecular imaging technique is more accurate than conventional medical imaging and recommends the scans be introduced into routine clinical practice.
Common genetic defect in prostate cancer inspires path to new anti-cancer drugs
Researchers found that, in prostate cancer, a mutation leading to the loss of one allele of a tumor suppressor gene known as PPP2R2A is enough to worsen a tumor caused by other mutations.
First prostate cancer therapy to target genes delays cancer progression
For the first time, prostate cancer has been treated based on the genetic makeup of the cancer, resulting in delayed disease progression, delayed time to pain progression, and potentially extending lives in patients with advanced, metastatic prostate cancer, reports a large phase 3 trial.
Men taking medications for enlarged prostate face delays in prostate cancer diagnosis
University of California San Diego School of Medicine researchers report that men treated with medications for benign prostatic hyperplasia (enlarged prostate) experienced a two-year delay in diagnosis of their prostate cancer and were twice as likely to have advanced disease upon diagnosis.
CNIO researchers confirm links between aggressive prostate cancer and hereditary breast cancer
The study has potential implications for families with members suffering from these types of tumours who are at an increased risk of developing cancer.
Distinguishing fatal prostate cancer from 'manageable' cancer now possible
Scientists at the University of York have found a way of distinguishing between fatal prostate cancer and manageable cancer, which could reduce unnecessary surgeries and radiotherapy.
Researchers find prostate cancer drug byproduct can fuel cancer cells
A genetic anomaly in certain men with prostate cancer may impact their response to common drugs used to treat the disease, according to new research at Cleveland Clinic.
ASCO and Cancer Care Ontario update guideline on radiation therapy for prostate cancer
The American Society of Clinical Oncology (ASCO) and Cancer Care Ontario today issued a joint clinical practice guideline update on brachytherapy (internal radiation) for patients with prostate cancer.
Patient prostate tissue used to create unique model of prostate cancer biology
For the first time, researchers have been able to grow, in a lab, both normal and primary cancerous prostate cells from a patient, and then implant a million of the cancer cells into a mouse to track how the tumor progresses.
Moffitt Cancer Center awarded $3.2 million grant to study bone metastasis in prostate cancer
Moffitt researchers David Basanta, Ph.D., and Conor Lynch, Ph.D., have been awarded a U01 grant to investigate prostate cancer metastasis.
More Prostate Cancer News and Prostate Cancer Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: Reinvention
Change is hard, but it's also an opportunity to discover and reimagine what you thought you knew. From our economy, to music, to even ourselves–this hour TED speakers explore the power of reinvention. Guests include OK Go lead singer Damian Kulash Jr., former college gymnastics coach Valorie Kondos Field, Stockton Mayor Michael Tubbs, and entrepreneur Nick Hanauer.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Dispatch 6: Strange Times
Covid has disrupted the most basic routines of our days and nights. But in the middle of a conversation about how to fight the virus, we find a place impervious to the stalled plans and frenetic demands of the outside world. It's a very different kind of front line, where urgent work means moving slow, and time is marked out in tiny pre-planned steps. Then, on a walk through the woods, we consider how the tempo of our lives affects our minds and discover how the beats of biology shape our bodies. This episode was produced with help from Molly Webster and Tracie Hunte. Support Radiolab today at