Serotonin boosts neuronal powerplants protecting against stress

May 09, 2019

Mitochondria in neurons are the powerhouses that generate energy to execute cellular functions and regulate neuronal survival under conditions of stress. Collaborative research by Prof. Vidita Vaidya and Prof. Ullas Kolthur-Seetharam groups at TIFR, along with Dr. Ashok Vaidya, at Medical Research Centre, Kasturba Health Society, has demonstrated an unusual function for the neurotransmitter serotonin, in the generation of new mitochondria--a process called mitochondrial biogenesis--in neurons, accompanied by increase in cellular respiration and ATP, the energy currency of the cell.

These effects of serotonin involve the serotonin2A receptor and master regulators of mitochondrial biogenesis, SIRT1 and PGC-1α. Serotonin reduces toxic reactive oxygen species in neurons, boosts anti-oxidant enzymes and buffers neurons from the damaging effects of cellular stress. This study (Fanibunda et al., 2019), appearing in the international journal PNAS, uncovers an unprecedented role for serotonin in energy production in neurons directly impacting how neurons handle stress. Mitochondrial function in neurons is vital in determining how neurons cope with stress and the trajectory of aging.

This work provides exciting evidence that the neurotransmitter serotonin can directly influence neuronal powerplants, thus impacting the manner in which neurons grapple with stress. This work identifies novel drug targets for treating mitochondrial dysfunction in neurons, with therapeutic potential for neurodegenerative and psychiatric disorders.
-end-


Tata Institute of Fundamental Research

Related Stress Articles from Brightsurf:

Stress-free gel
Researchers at The University of Tokyo studied a new mechanism of gelation using colloidal particles.

Early life stress is associated with youth-onset depression for some types of stress but not others
Examining the association between eight different types of early life stress (ELS) and youth-onset depression, a study in JAACAP, published by Elsevier, reports that individuals exposed to ELS were more likely to develop a major depressive disorder (MDD) in childhood or adolescence than individuals who had not been exposed to ELS.

Red light for stress
Researchers from the Institute of Industrial Science at The University of Tokyo have created a biphasic luminescent material that changes color when exposed to mechanical stress.

How do our cells respond to stress?
Molecular biologists reverse-engineer a complex cellular structure that is associated with neurodegenerative diseases such as ALS

How stress remodels the brain
Stress restructures the brain by halting the production of crucial ion channel proteins, according to research in mice recently published in JNeurosci.

Why stress doesn't always cause depression
Rats susceptible to anhedonia, a core symptom of depression, possess more serotonin neurons after being exposed to chronic stress, but the effect can be reversed through amygdala activation, according to new research in JNeurosci.

How plants handle stress
Plants get stressed too. Drought or too much salt disrupt their physiology.

Stress in the powerhouse of the cell
University of Freiburg researchers discover a new principle -- how cells protect themselves from mitochondrial defects.

Measuring stress around cells
Tissues and organs in the human body are shaped through forces generated by cells, that push and pull, to ''sculpt'' biological structures.

Cellular stress at the movies
For the first time, biological imaging experts have used a custom fluorescence microscope and a novel antibody tagging tool to watch living cells undergoing stress.

Read More: Stress News and Stress Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.