New gene for familial high cholesterolMay 12, 2016
New research from Denmark reveals the gene that explains one quarter of all familial hypercholesterolemia with very high blood cholesterol. Familial hypercholesterolemia is the most common genetic disorder leading to premature death, found in 1 in 200 people.
A research group lead by Clinical Professor Borge G. Nordestgaard has found that cholesterol-containing lipoprotein(a) is the cause of one quarter of all diagnoses of familial hypercholesterolemia. High levels of this genetically determined lipoprotein in the blood is already known to cause heart attacks.
"Among 46,200 individuals in the general population, individuals with a diagnosis of familial hypercholesterolemia have higher levels of lipoprotein(a) in their blood than individuals without the diagnosis," says principal investigator Dr. Anne Langsted, Herlev Hospital, Copenhagen University Hospital, Denmark.
The research has just been published in The Lancet Diabetes & Endocrinology.
High risk of heart attack
The study also reveals that high levels of lipoprotein(a) in the blood adds to the already very high risk of suffering a heart attack for people with familial hypercholesterolemia. "We find that individuals with familial hypercholesterolemia and high levels of lipoprotein(a) are five times more likely to suffer a heart attack than individuals without these two conditions," adds Anne Langsted.
"Our results suggest that all individuals with familial hypercholesterolemia should have their lipoprotein(a) concentrations measured in order to identify those with the highest concentrations and therefore also the highest risk of suffering a heart attack," says senior author Borge G. Nordestgaard, University of Copenhagen and Copenhagen University Hospital.
"Worldwide, familial hypercholesterolemia as well as high lipoprotein(a) levels are grossly underdiagnosed and undertreated. Our findings will help identify the individuals with the highest risk of suffering a heart attack and hopefully facilitate better preventive treatment for these extremely high risk individuals," adds Nordestgaard.
The diagnosis of familial hypercholesterolemia is based on different clinical signs such as elevated cholesterol, relatives with early heart attack and a personal history of heart attack. Genetic testing can also confirm the diagnosis.
University of Copenhagen The Faculty of Health and Medical Sciences
Related Heart Attack Articles:
People living in parts of Ontario with better access to preventive health care had lower rates of cardiac events compared to residents of regions with less access, found a new study published in CMAJ (Canadian Medical Association Journal).
Chronic inflammation after a heart attack can promote heart failure and death.
Does a stay in the intensive care unit give patients a better chance of surviving a chronic obstructive pulmonary disease (COPD) or heart failure flare-up or even a heart attack, compared with care in another type of hospital unit?
Researchers at the University of Cincinnati have received $2.4 million in federal funding to pursue research on a novel cell therapy that would repair heart damage using modified cells taken from the patient's own facial muscle.
Researchers have grown heart tissue by seeding a mix of human cells onto a 1-micron-resolution scaffold made with a 3-D printer.
Researchers delivered human stem cells seeded in biological sutures to the damaged heart muscles of rats following induced acute myocardial infarction and assessed the effects on cardiac function one week later.
For patients age 50 and younger, the risk of premature death after a heart attack has dropped significantly, but their risk is still almost twice as high when compared to the general population, largely due to heart disease and other smoking-related diseases The risk of heart attack can be greatly reduced by quitting smoking, exercising and following a healthy diet.
During a heart attack, clots or narrowed arteries block blood flow, harming or killing cells in the heart.
People who develop heart failure after their first heart attack have a greater risk of developing cancer when compared to first-time heart attack survivors without heart failure, according to a study today in the Journal of the American College of Cardiology.
One in four patients develop heart failure within four years of a first heart attack, according to a study in nearly 25,000 patients presented today at Heart Failure 2016 and the 3rd World Congress on Acute Heart Failure by Dr.
Related Heart Attack Reading:
Beat the Heart Attack Gene: The Revolutionary Plan to Prevent Heart Disease, Stroke, and Diabetes
by Bradley Bale M.D. (Author), Amy Doneen ARNP (Author), Lisa Collier Cool (Contributor), Larry King (Contributor)
A revolutionary, personalized guide to preventing heart disease based on genetic factors
Heart disease is the #1 cause of death in America. It affects 81 million Americans and is the culprit in one of every two deaths in the United States. Most people think that they are not at risk of a heart attack if they control their cholesterol and blood pressure, but they aren’t aware of other major risk factors. The good news is that with the right information and strategies, heart attacks are preventable—even if heart disease runs in the family.
In Beat the Heart... View Details
Prevent a Second Heart Attack: 8 Foods, 8 Weeks to Reverse Heart Disease
by Janet Bond Brill Ph.D. R.D. (Author), Annabelle S. Volgman M.D. (Foreword)
Reverse Your Heart Disease in Just Eight Weeks by Harnessing the Power of the Mediterranean Diet
If you’re one of the 13 million Americans who have survived a heart attack or been diagnosed with heart disease, Dr. Janet Bond Brill offers a delicious and foolproof plan that can lower your risk of a second heart attack by up to 70 percent. Inspired by the heart-healthy Mediterranean diet, the Prevent a Second Heart Attack Plan is based on satisfaction, rather than deprivation.
Backed by cutting edge research, Dr. Brill explains:
• Why the... View Details
Fat and Cholesterol Don't Cause Heart Attacks and Statins are Not The Solution
by Paul J. Rosch MD (Author), Zoë Harcombe PhD (Author), Malcolm Kendrick MD (Author), Uffe Ravnskov MD PhD (Author), Fred A. Kummerow PhD (Author), Harumi Okuyama PhD (Author), Peter H. Langsjoen MD (Author), Alena M. Langsjoen MS (Author), Naoki Ohara PhD (Author), David M. Diamond PhD (Author), Tomohito Hamazaki MD PhD (Author), Stephanie Seneff PhD (Author), Carlos Monteiro (Author), Kilmer S. McCully MD (Author), Luca Mascitelli MD (Author), Mark R. Goldstein MD (Author), Michel de Lorgeril MD (Author), Mikael Rabaeus MD (Author), Duane Graveline MD MPH (Author), Sherif Sultan MD Phd (Author), Edel P. Kavanagh PhD (Author)
This book is dedicated to Uffe Ravnskov, MD, Ph.D. for his seminal and propaedeutic achievements in disputing the dogma that fat and cholesterol cause coronary heart disease, and that statins are safe and cardioprotective for everyone. As will be seen, no studies support the notion that restricting fat reduces coronary morbidity or mortality. More importantly, government recommendations mandating low fat diets are likely the cause of the escalating epidemic of obesity and type 2 diabetes. Several chapters detail the panoply of significant adverse health effects of statins that have been... View Details
Heart Attack Proof: A Six-Week Cardiac Makeover for a Lifetime of Optimal Health
by Michael Ozner (Author)
A combination of the newest blood tests, medications, and nutrition approaches have made coronary heart disease preventable, but for most of us, it’s still not a question of if, but when. Renowned and leading preventive cardiologist Michael Ozner says there’s no reason to wait until you have a heart attack or stroke.
In Heart Attack Proof, Dr. Ozner shares the same six-week cardiac makeover to prevent and reverse heart disease he has been successfully giving his patients for more than 25 years. Even if you’ve been diagnosed with heart disease or have... View Details
The Cardiac Recovery Cookbook: Heart Healthy Recipes for Life After Heart Attack or Heart Surgery
by M. Laurel Cutlip (Author)
Help Your Heart by Eating Right!
If you are looking to eat healthier and still enjoy mealtime, open your kitchen to The Cardiac Recovery Cookbook. This indispensable companion to The Cardiac Recovery Handbook contains over 100 quick, easy, and delicious NIH-approved recipes to help cardiac patients eat well on the road to wellness.
Whether you want a quick meal, a nutritious dinner, or a heart-healthy dessert, this book is packed with great tasting recipes the whole family can enjoy.
All the recipes are reduced in saturated fat, cholesterol, and... View Details
Prevent and Reverse Heart Disease: The Revolutionary, Scientifically Proven, Nutrition-Based Cure
by Caldwell B. Esselstyn Jr. (Author)
The New York Times bestselling guide to the lifesaving diet that can both prevent and help reverse the effects of heart disease
Based on the groundbreaking results of his twenty-year nutritional study, Prevent and Reverse Heart Disease by Dr. Caldwell Esselstyn illustrates that a plant-based, oil-free diet can not only prevent the progression of heart disease but can also reverse its effects. Dr. Esselstyn is an internationally known surgeon, researcher and former clinician at the Cleveland Clinic and a featured expert in the acclaimed documentary Forks... View Details
Too Young for a Heart Attack
by Stu Segal (Author), Stephen H. Segal (Consultant Editor), Dr. Ian J. Molk M.D. (Consultant Editor)
Stu Segal was a fit, healthy 37-year-old--or that's what he thought until Fathers' Day 1987 ended with a heart attack. When the ER doctor told him he might or might not survive, he realized that, one way or another, life as he knew it was over.
Stu traces the journey of a man facing the new reality that though much of what he loved was gone, yes, he might still be able to live a long and happy life--if he methodically changed his approach to the things he'd always taken for granted. Over the course of weeks, months and years, Stu says goodbye to the habits he's used to and rebuilds... View Details
The Heart Attack Sutra: A New Commentary on the Heart Sutra
by Karl Brunnholzl (Author)
The radical message of the Heart Sūtra, one of Buddhism's most famous texts, is a sweeping attack on everything we hold most dear: our troubles, the world as we know it, even the teachings of the Buddha himself. Several of the Buddha's followers are said to have suffered heart attacks and died when they first heard its assertion of the basic groundlessness of our existence—hence the title of this book. Overcoming fear, the Buddha teaches, is not to be accomplished by shutting down or building walls around oneself, but instead by opening up to understand the illusory nature of... View Details
Heart 411: The Only Guide to Heart Health You'll Ever Need
by Marc Gillinov M.D. (Author), Steven Nissen M.D. (Author)
The definitive guide to heart health from two of America's most respected doctors at Cleveland Clinic, the #1 hospital for heart health in America.
Are you one of the eighty-two million Americans currently diagnosed with cardiovascular disease—or one of the millions more who think they are healthy but are at risk? Whether your goal is to get the best treatment or stay out of the cardiologist’s office, your heart's health depends upon accurate information and correct answers to key questions.
In Heart 411, two renowned experts, heart surgeon Marc Gillinov and... View Details
Why Animals Don't Get Heart Attacks but People Do, Fourth Revised Edition
by Matthias Rath (Author)
In Why Animals Don’t Get Heart Attacks, But People Do, Matthias Rath, M.D., an internationally respected cardiovascular researcher, asserts that high cholesterol is not the actual cause of heart disease. Bears, for example, have average cholesterol levels of 400 milligrams per deciliter of blood, but they don’t suffer heart attacks. Why? According to Dr. Rath, it is because bears produce large amounts of vitamin C, which optimizes collagen production and ensures maximum stability of their artery walls.
Dr. Rath’s research identifies the true cause of heart disease as a deficiency of... View Details