Fine particulate matter may increase mortality among young patients with certain cancers

May 13, 2020

Bottom Line: An analysis of nearly 16,000 young patients with cancer in Utah revealed that exposure to fine particulate matter was associated with increased mortality at five and 10 years after diagnosis of certain cancers.

Journal in Which the Study was Published:Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research; this paper will be featured in a forthcoming Environmental Carcinogenesis Focus section in the journal.

Author: Judy Ou, PhD, research scientist at the Huntsman Cancer Institute at the University of Utah in Salt Lake City

Background: "It is estimated that roughly 40 percent of Americans live in communities with unhealthy levels of air pollution," said Ou. "Currently, there are no guidelines for long-term cancer survivors that advise reducing exposure to air pollution, nor are cancer patients considered a population vulnerable to mortality or illness from air pollution. Our results suggest that limiting exposure to fine particulate matter may be important for the survival of younger cancer patients with specific cancers."

Studies have shown associations between increased exposure to fine particulate matter, defined as atmospheric particles less than 2.5 micrometers in diameter, and cancer mortality among adult breast, liver, and lung cancer patients, yet the underlying biology of cancers in young patients potentially differs from cancers in adults, Ou explained. "Because the associations observed between exposure to fine particulate matter and increased cancer mortality in adults cannot be easily extrapolated to younger cancer patients, we wanted to study how continued exposure to fine particulate matter after diagnosis affected survival outcomes in this specific population," she said.

How the Study was Conducted: Using information from the Utah Population Database and Utah Cancer Registry, Ou and colleagues followed 2,444 pediatric (ages 0 to 14) and 13,459 young adult and adolescent (AYA; ages 15 to 39) patients diagnosed with cancer while living in Utah from 1986 to 2015. These patients were followed from diagnosis to the clinically relevant time points of five and 10 years after diagnosis.

To estimate cumulative exposure to fine particulate matter, the researchers used data from stationary monitors provided by the Environmental Protection Agency (EPA). Using this information, the researchers could model the association between cumulative exposure and mortality from cancer and all-causes. The exposure to fine particulate matter was measured continuously (in increments of 5 micrograms per cubic meter of air; μg/m3) and categorically (if exposure was equal to/exceeded the EPA annual standard of 12 μg/m3, based on the three-year average of annual mean concentration of fine particulate matter) for these models. Models were adjusted for sex, race/ethnicity, and socioeconomic status, among other factors.

Results: Among pediatric patients, exposure to fine particulate matter was associated with an increased risk of death for the following specific cancers:Overall, among AYA patients, exposure to fine particulate matter was associated with an increased risk of cancer mortality and all-cause mortality at both time points when exposure was measured categorically. Exposure to fine particulate matter was associated with an increased risk of all-cause mortality at five years post diagnosis when exposure was measured continuously.

Further, among AYA patients, exposure to fine particulate matter was associated with an increased risk of death for the following specific cancers:Author's Comments: "Exposure to air pollution is preventable to a degree on an individual level, but the responsibility ultimately lies with government policy to protect the public from this major health hazard," said Ou. "We need patients and their caregivers to become informed advocates to support enforcing air quality policies at the local, state, and federal levels."

Study Limitations: As a limitation to the study, data for 1999 to 2015 were collected from stationary monitors measuring fine particulate matter throughout the state of Utah, but the data for 1986 to 1998 were collected from stationary monitors measuring coarse particulate matter, defined as atmospheric particles less than 10 micrometers in diameter, in four Utah counties that contain 80 percent of Utah's population. "While fine particulate matter was not measured directly from 1986 to 1998, coarse particulate matter and fine particulate matter measurements are highly related, allowing us to extrapolate measures of fine particulate matter during these years," Ou explained.
Funding & Disclosures: This study was sponsored by a grant from St. Baldrick's Foundation, grants from the National Institute of Health (NIH)/National Cancer Institute (NCI), and NCI's Geographic Management of Cancer Health Disparities program at the Huntsman Cancer Institute.

Partial support for all datasets within the Utah Population Database was provided by the University of Utah Huntsman Cancer Institute and the Huntsman Cancer Institute Cancer Center Support grant from the National Cancer Institute.

The Utah Cancer Registry is funded by the National Cancer Institute's SEER Program and the U.S. Centers for Disease Control and Prevention's National Program of Cancer Registries, with additional support from the University of Utah and Huntsman Cancer Foundation. Ou declares no conflict of interest.

About the American Association for Cancer Research

Founded in 1907, the American Association for Cancer Research (AACR) is the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR membership includes 47,000 laboratory, translational, and clinical researchers; population scientists; other health care professionals; and patient advocates residing in 126 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis, and treatment of cancer by annually convening more than 30 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 22,500 attendees. In addition, the AACR publishes eight prestigious, peer-reviewed scientific journals and a magazine for cancer survivors, patients, and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the Scientific Partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration, and scientific oversight of team science and individual investigator grants in cancer research that have the potential for near-term patient benefit. The AACR actively communicates with legislators and other policymakers about the value of cancer research and related biomedical science in saving lives from cancer. For more information about the AACR, visit

American Association for Cancer Research

Related Cancer Articles from Brightsurf:

New blood cancer treatment works by selectively interfering with cancer cell signalling
University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published in Nature Communications.

UCI researchers uncover cancer cell vulnerabilities; may lead to better cancer therapies
A new University of California, Irvine-led study reveals a protein responsible for genetic changes resulting in a variety of cancers, may also be the key to more effective, targeted cancer therapy.

Breast cancer treatment costs highest among young women with metastic cancer
In a fight for their lives, young women, age 18-44, spend double the amount of older women to survive metastatic breast cancer, according to a large statewide study by the University of North Carolina at Chapel Hill.

Cancer mortality continues steady decline, driven by progress against lung cancer
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported.

Stress in cervical cancer patients associated with higher risk of cancer-specific mortality
Psychological stress was associated with a higher risk of cancer-specific mortality in women diagnosed with cervical cancer.

Cancer-sniffing dogs 97% accurate in identifying lung cancer, according to study in JAOA
The next step will be to further fractionate the samples based on chemical and physical properties, presenting them back to the dogs until the specific biomarkers for each cancer are identified.

Moffitt Cancer Center researchers identify one way T cell function may fail in cancer
Moffitt Cancer Center researchers have discovered a mechanism by which one type of immune cell, CD8+ T cells, can become dysfunctional, impeding its ability to seek and kill cancer cells.

More cancer survivors, fewer cancer specialists point to challenge in meeting care needs
An aging population, a growing number of cancer survivors, and a projected shortage of cancer care providers will result in a challenge in delivering the care for cancer survivors in the United States if systemic changes are not made.

New cancer vaccine platform a potential tool for efficacious targeted cancer therapy
Researchers at the University of Helsinki have discovered a solution in the form of a cancer vaccine platform for improving the efficacy of oncolytic viruses used in cancer treatment.

American Cancer Society outlines blueprint for cancer control in the 21st century
The American Cancer Society is outlining its vision for cancer control in the decades ahead in a series of articles that forms the basis of a national cancer control plan.

Read More: Cancer News and Cancer Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to