Yes, inflammatory bowel disease and celiac disease are linked

May 13, 2020

Hamilton, ON (May 13, 2020) - McMaster University researchers have established a connection between inflammatory bowel disease (IBD) and celiac disease.

A systematic review and meta-analysis at the Farncombe Family Digestive Health Research Institute at McMaster in collaboration with the Society for the Study of Celiac Disease has determined there is a nine-fold increased risk of having IBD for patients with a previous diagnosis of celiac disease. Similarly, the risk for celiac disease is increased in IBD patients, though to a smaller extent.

The details were published today in Gastroenterology.

"Clinicians have always suspected that IBD and celiac disease may be linked, however a clear association was never established," said first study author Maria Ines Pinto-Sanchez, associate professor of medicine and member of the Farncombe Family Digestive Health Research Institute at McMaster. She is a gastroenterologist with Hamilton Health Sciences.

"This is important, as failure to diagnose one or the other condition could compromise proper response to available treatments. It also raises questions on screening for the other disease in a patient already diagnosed with either IBD or celiac disease."

IBD and celiac disease are chronic and disabling intestinal conditions affecting many Canadians as Canada has one of the highest frequencies of IBD in the world. Both diseases share similar risk factors and their prevalence has increased in the past years.

While the exact cause of IBD is unknown, it is accepted that infections, genes and other environmental factors are involved. Celiac disease affects 1 in 100 Canadians, and its main environmental trigger is dietary gluten, but specific genes are required to develop the condition.

The researchers identified 9,800 studies and included 65 studies in their analysis. Of those, 30 studies included control groups with a total of 13.6 million participants, including: 43,000 celiac patients, 166,000 IBD patients (39,000 Crohn's, 56,000 ulcerative colitis, and 3,000 indeterminate colitis patients), and 13.4 million controls.

The studies were published between 1978 and 2019. Forty-three studies were conducted in adults, 12 studies in children, and 9 studies in all ages. The majority of the studies were in Europe, followed by North America and Asia.

The researchers suggest the next step is to determine whether testing for the diseases is cost-effective and beneficial to patients.

"Our review has confirmed that there is a strong association between celiac disease and IBD, but at this time, it is unclear whether screening of IBD should be performed in celiac disease and vice versa," said corresponding study author Elena Verdu, professor of medicine and scientist of the Farncombe Family Digestive Health Research Institute at McMaster.

"More studies into the association of IBD and celiac disease are needed, as this could lead to screening and therapeutic interventions to improve patient outcomes."
-end-
The study was funded by the Society for the Study of Celiac Disease.

For more information:

Veronica McGuire
Media Relations
McMaster University
vmcguir@mcmaster.ca
289-776-6952

McMaster University

Related Inflammatory Bowel Disease Articles from Brightsurf:

People with inflammatory bowel disease still die earlier despite increase in life
A study comparing life expectancy of people with inflammatory bowel disease (IBD) and without found that, while life expectancy increased for both groups, people with IBD generally died sooner.

Cell therapy designed to treat inflammatory bowel disease
The UPV/EHU's NanoBioCel research group has for many years been developing systems enabling cells to be used as drugs.

Team develops wearable sensor to help people with inflammatory bowel disease
University of Texas at Dallas researchers have designed a wearable device that monitors sweat for biomarkers that could signal flare-ups of inflammatory bowel disease (IBD).

Antibiotics associated with increased risk of inflammatory bowel disease
Antibiotics use, particularly antibiotics with greater spectrum of microbial coverage, may be associated with an increased risk of new-onset inflammatory bowel disease (IBD) and its subtypes ulcerative colitis and Crohn's disease.

Yes, inflammatory bowel disease and celiac disease are linked
A systematic review and meta-analysis that has determined there is a nine-fold increased risk of having IBD for patients with a previous diagnosis of celiac disease.

The effects of inflammatory bowel disease on pregnancy
Inflammatory bowel disease (IBD) -- including Crohn's disease and ulcerative colitis -- often affects women of childbearing age.

5 major advances in inflammatory bowel disease (IBD) treatment
Summary of five impactful studies to be presented at the Crohn's & Colitis Congress, a partnership of the Crohn's & Colitis Foundation and the American Gastroenterological Association (AGA).

Researchers identify a possible cause and treatment for inflammatory bowel disease
In a study published online in PNAS on Jan. 20, 2020, Prof.

Does inflammatory bowel disease carry certain risks during pregnancy?
Pregnant women with inflammatory bowel disease (IBD) are more likely to undergo delivery by Caesarean section and face certain risks during pregnancy, according to an analysis published in Alimentary Pharmacology & Therapeutics.

Inhibiting a protease could improve the treatment of inflammatory bowel disease
Scientists at the CNIC and CSIC have identified a function of a protease that could be the future target of drugs to treat inflammatory bowel disease.

Read More: Inflammatory Bowel Disease News and Inflammatory Bowel Disease Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.