New kidney cancer drug response rate is more than double that of standard treatment

May 14, 2005

Orlando, May 14, 2005 -Recent studies of a new anticancer drug show continued response for patients with late-stage kidney cancer. Robert Motzer, MD, attending physician at Memorial Sloan-Kettering Cancer Center (MSKCC), reported a response rate of 40 percent in patients with metastatic (advanced) renal cell (kidney) cancer who received SU11248 in second-line therapy. Findings from two consecutive, Phase II multicenter trials of 169 patients were presented today at the annual meeting of the American Society for Clinical Oncology (ASCO).

"Continuing with our study of SU11248 treatment for renal cell cancer, first reported at last year's annual ASCO meeting, we found a partial response rate for 40 percent of patients, with 6 of the 25 patients having a continuous response for greater than 12 months," said Dr. Motzer, principal investigator of the trials. "In the second trial, both partial and complete responses have been observed, indicating that SU11248 is a very active agent in the treatment of a disease for which standard treatment provides only a 15 percent response rate."

In the first trial, 63 patients with metastatic renal cell carcinoma, whose cancer had failed to respond to standard therapy, received SU11248. Twenty-five of them (40 percent) showed a partial response to the drug; in 21 patients (33 percent), the disease stabilized. Of the 25 patients who achieved a partial response, the median duration of partial response was 10 plus months. Eight of the patients remain progression-free, including two whose tumors became operable as a result of the treatment. The median time to progression was 8.7 months; the median survival was 16 months; six patients remain on therapy.

In a second trial, 106 patients have been treated and were assessed for a response. Of the 106 patients, 41 (39 percent) had tumor shrinkage greater than 30 percent, including one patient whose cancer is in complete remission. The drug was generally well-tolerated, with patients experiencing mild- to-moderate side effects that include fatigue, nausea, diarrhea, and stomatitis (mouth inflammation).

According to American Cancer Society estimates, kidney cancer will be diagnosed in approximately 36,160 people this year; 22,490 will be men. The disease will be responsible for about 12,660 deaths, almost two-thirds of them men. Standard treatment for metastatic kidney cancer is interleukin-2 and interferon-alpha. These agents have a response rate of 15 percent and cause significant side effects for virtually all treated patients.

The orally administered agent SU11248 is a multi targeted tyrosine kinase inhibitor, which works by simultaneously blocking two growth factor receptors, a vascular endothelial growth factor receptor, and a platelet-derived growth factor receptor. By targeting multiple receptors, SU11248 cuts off the blood supply to the tumor and destroys cellular reproduction.

Physicians in the SU11248 Study Group from Memorial Sloan-Kettering, the University of California, San Francisco, Massachusetts General Hospital, the University of Michigan Hospital, the Fox Chase Cancer Center, the University of Wisconsin, the Cleveland Clinic Foundation, and Duke University participated in the multicenter study led by Dr. Motzer. The study was sponsored by Pfizer Pharmaceuticals.
-end-
Memorial Sloan-Kettering Cancer Center is the world's oldest and largest institution devoted to prevention, patient care, research, and education in cancer. Our scientists and clinicians generate innovative approaches to better understand, diagnose, and treat cancer. Our specialists are leaders in biomedical research and in translating the latest research to advance the standard of cancer care worldwide. For more information, go to www.mskcc.org

Memorial Sloan Kettering Cancer Center

Related Cancer Articles from Brightsurf:

New blood cancer treatment works by selectively interfering with cancer cell signalling
University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published in Nature Communications.

UCI researchers uncover cancer cell vulnerabilities; may lead to better cancer therapies
A new University of California, Irvine-led study reveals a protein responsible for genetic changes resulting in a variety of cancers, may also be the key to more effective, targeted cancer therapy.

Breast cancer treatment costs highest among young women with metastic cancer
In a fight for their lives, young women, age 18-44, spend double the amount of older women to survive metastatic breast cancer, according to a large statewide study by the University of North Carolina at Chapel Hill.

Cancer mortality continues steady decline, driven by progress against lung cancer
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported.

Stress in cervical cancer patients associated with higher risk of cancer-specific mortality
Psychological stress was associated with a higher risk of cancer-specific mortality in women diagnosed with cervical cancer.

Cancer-sniffing dogs 97% accurate in identifying lung cancer, according to study in JAOA
The next step will be to further fractionate the samples based on chemical and physical properties, presenting them back to the dogs until the specific biomarkers for each cancer are identified.

Moffitt Cancer Center researchers identify one way T cell function may fail in cancer
Moffitt Cancer Center researchers have discovered a mechanism by which one type of immune cell, CD8+ T cells, can become dysfunctional, impeding its ability to seek and kill cancer cells.

More cancer survivors, fewer cancer specialists point to challenge in meeting care needs
An aging population, a growing number of cancer survivors, and a projected shortage of cancer care providers will result in a challenge in delivering the care for cancer survivors in the United States if systemic changes are not made.

New cancer vaccine platform a potential tool for efficacious targeted cancer therapy
Researchers at the University of Helsinki have discovered a solution in the form of a cancer vaccine platform for improving the efficacy of oncolytic viruses used in cancer treatment.

American Cancer Society outlines blueprint for cancer control in the 21st century
The American Cancer Society is outlining its vision for cancer control in the decades ahead in a series of articles that forms the basis of a national cancer control plan.

Read More: Cancer News and Cancer Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.