A promising target of anti-fibrotic therapy: herbal compound 861

May 14, 2008

Cpd861, a traditional Chinese medicine extracted from 10 herbs, has anti-fibrotic effects and is used in treatment of liver diseases such as cirrhosis. Randomized double-blinded and placebo-controlled clinical trials have proved that Cpd861 can significantly delay and reverse hepatic fibrosis due to HBV infection.

The research team led by Dr. Bao-En Wang from Capital Medical University studied the molecular mechanism of Cpd861 underlying the inactivation of LX-2 cells, effect of Cpd861 on the expression of genes such as ALK1and Id1, and protein level of phosphorylated Smad1 in the TGF beta1/ALK1/Smad1 signaling pathway. The results indicate that the TGF beta1/ALK1/Smad1 signaling pathway can be activated by TGF- beta1, inhibited by Cpd861, and is, therefore, a potential target of anti-fibrotic therapy.
-end-


World Journal of Gastroenterology

Related Signaling Pathway Articles from Brightsurf:

Researchers identify 'druggable' signaling pathway that stimulates lung tissue repair
Researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have identified a cellular pathway that can be targeted with a naturally occurring drug to stimulate lung tissue regeneration, which is necessary for recovery from multiple lung injuries.

Key signaling pathway in the pathogenesis of Paget's disease identified
Researchers from the University of California, Irvine, in collaboration with their colleagues from Beijing, China, have gained new insights into the development of malignant skin cancers collectively known as Paget's disease.

Mouse study shows nerve signaling pathway critical to healing fractures
Sticks and stones may break one's bones, but healing them requires the production of a protein signal that stimulates the generation, growth and spread of vital nerve cells, or neurons, throughout the injured area.

A common insulin signaling pathway across cancer and diabetes
An oncology researcher has made an unexpected contribution to the understanding of type 2 diabetes.

Insects share the same signaling pathway to form their 3-dimensional body
Zoologist shows that beetles, bugs and crickets control their body shape through Fog signalling / publication in 'eLife'.

A new signaling pathway for mTor-dependent cell growth
A team led by the scientist Volker Haucke (Leibniz - Forschungsinstitut für Molekulare Pharmakologie and Freie Universität Berlin) has now discovered how inactivation of a certain lipid kinase promotes mTor complex 1 activity, and may therefore constitute a new point of attack for the treatment of diabetes and cancer.

Chemical probe can regulate signaling pathway and block cell invasion by arboviruses
Dysregulation of the signaling pathway known as the beta-catenin-dependent Wnt can also cause embryo malformation and contribute for the development of breast and cervical cancer.

Important signaling pathway in breast cancer revealed
Researchers at Kanazawa University report in Proceedings of the National Academy of Sciences of the United States of America (PNAS) that a particular signaling pathway in breast-cancer tumors causes cancer cells to divide symmetrically, expanding the tumor.

Colon signaling pathway key to inflammatory bowel disease
Inflammatory bowel disease (IBD) develops because of an uncontrolled immune response in the colon.

Signaling pathways to the nucleus
Researchers have demonstrated how auxin, a hormone that controls many processes in plants, reaches its destination.

Read More: Signaling Pathway News and Signaling Pathway Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.