Why do black pigment stones cause gallbladder contractility function disorder?

May 14, 2008

Chemically, black pigment stones is the polymerized bilirubin with metals. Therefore, environments suitable for the formation of black pigment stones are conditions that allow chemical polymerization with sufficient time. However, there have been very few reports describing the gallbladder motility with special reference to the pathogenesis of black pigment stones formation to date.

A research article to be published on May 14, 2008 in the World Journal of Gastroenterology addresses this question. The research led by Professor, Hakamada from Department of Surgery, Hirosaki University, analyzed physiological patterns of bile evacuation from the gallbladder quantitatively by cholescintigraphy.

In this article, the authors observed significantly shorter ejection periods and ejection fractions in 14 patients with black pigment stones in comparison to those in 22 cholesterol stone patients and 28 normal subjects. Consequently, ejection rate of the gallbladder emptying was found significantly smaller in patients with black pigment stones, they reported.

Over the past century, many studies have been conducted to disclose a close association with gallbladder dysmotility and gallstone diseases. Previous studies, however, have yielded conflicting results. In the view of the authors, these conflicting results derived in part from different methodology to assess gallbladder motility, and also from the facts that these studies were conducted without taking into account the chemical characteristics of their stones.

By using a less invasive method of computer cholescintigraphy and selecting patients according to their backgrounds strictly, they concluded that bile stagnation due to impaired gallbladder kinetics seems one of the predisposing factors for the development of black pigment stones.

These results demonstrate a new view of disease mechanism of this old common disease, and thus may progress the understanding the relation between physiological aspects and the epidemiology of the gallstone diseases.
-end-


World Journal of Gastroenterology

Related Article Articles from Brightsurf:

OHIO professor publishes first article that looks at concussion risk in stunt performers
Dr. Jeff Russell, associate professor of athletic training within the College of Health Sciences and Professions at Ohio University, is shining a light on a segment of concussion patients who often go unnoticed in comparison to athletes: performing artists.

"Liking" an article online may mean less time spent reading it
When people have the option to click ''like'' on a media article they encounter online, they spend less time actually reading the text, a new study suggests.

New article clarifies details of COVID-19 respiratory transmission
In a new article, scientists provide an exhaustive, evidence-based review of how COVID-19 droplets from infected patients spread through the air and describe how health care professionals can protect themselves.

NUI Galway mathematician publishes article in world's top mathematics journal
An Irish mathematician, Dr Martin Kerin, from the School of Mathematics, Statistics and Applied Mathematics at NUI Galway, has had a research article published in the Annals of Mathematics, widely regarded as the top journal for pure mathematics in the world.

December's SLAS technology feature article now available
Next month's SLAS Technology features the cover article, 'Automated System for Small-Population Single-Particle Processing Enabled by Exclusive Liquid Repellency,' outlining research led by Chao Li, Ph.D., (University of Wisconsin-Madison, USA)

Article proposes important mucin link between microbial infections and many cancers
In a review article, cancer biologists Pinku Mukherjee and Mukulika Bose argue that recent research suggests a mechanism that may implicate bacterial infections as important factors in epithelial cell cancers.

Rapamycin for longevity -- Opinion article
The scientist discusses several reasons, including fear of the actual and fictional side effects of rapamycin, everolimus and other clinically-approved drugs, arguing that no real side effects preclude their use as anti-aging drugs today.

August's SLAS technology cover article announced
The August edition of SLAS Technology features the cover article, 'Technologies for the Directed Evolution of Cell Therapies,' a review featured in the journal's March 2019 edition.

SLAS Discovery announces its June cover article
The June cover of SLAS Discovery features cover article 'A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction,' by Timothy M.

British Journal of Surgery article calls for men to take action on gender bias
The relatively few women who have earned leadership positions in the surgical world should not be expected to carry the burden of fighting gender bias and men must actively join the effort with intentional, innovative action, argues an article in the British Journal of Surgery, co-written by the head of general surgery at Toronto's St.

Read More: Article News and Article Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.