Nav: Home

Setting affects pleasure of heroin and cocaine

May 14, 2018

Drug users show substance-specific differences in the rewarding effects of heroin versus cocaine depending on where they use the drugs, according to a study published in JNeurosci. Considering this interaction between drug type and location in the treatment of addiction could help to prevent relapse.

Silvana De Pirro, Aldo Badiani, and colleagues recruited two groups of participants receiving treatment for substance use disorder at a medical center in Rome. The researchers asked the first group to recall a typical drug episode and indicate how arousing and pleasant their experience was with each drug (heroin or cocaine) in two different settings (at home or outside the home). With guidance, the second group imagined using the drugs in each setting while their brain activity was measured with functional magnetic resonance imaging.

The results show that users had a more pleasurable experience using heroin at home while cocaine use was more pleasurable outside the home, consistent with previous reports on drug preference in rats and humans. The brain regions activated during the emotional imagery task included those involved in processing drug reward and context: the prefrontal cortex, caudate, and cerebellum. The researchers conclude that the human response to addictive drugs depends on both the setting and substance of use.
-end-
Article: The affective and neural correlates of heroin vs. cocaine use in addiction are influenced by environmental setting but in opposite directions
DOI: https://doi.org/10.1523/JNEUROSCI.0019-18.2018
Corresponding authors: Silvana De Pirro, S.DePirro@sussex.ac.uk and Aldo Badiani, aldo.badiani@sussex.ac.uk (University of Sussex, Brighton, UK)

About JNeurosci

JNeurosci, the Society for Neuroscience's first journal, was launched in 1981 as a means to communicate the findings of the highest quality neuroscience research to the growing field. Today, the journal remains committed to publishing cutting-edge neuroscience that will have an immediate and lasting scientific impact, while responding to authors' changing publishing needs, representing breadth of the field and diversity in authorship.

About The Society for Neuroscience

The Society for Neuroscience is the world's largest organization of scientists and physicians devoted to understanding the brain and nervous system. The nonprofit organization, founded in 1969, now has nearly 37,000 members in more than 90 countries and over 130 chapters worldwide.

Society for Neuroscience

Related Cocaine Articles:

Of all professions, construction workers most likely to use opioids and cocaine
Construction workers are more likely to use drugs than workers in other professions, finds a study by the Center for Drug Use and HIV/HCV Research (CDUHR) at NYU College of Global Public Health.
Chronic cocaine use modifies gene expression
Chronic cocaine use changes gene expression in the hippocampus, according to research in mice recently published in JNeurosci.
Blocking dopamine weakens effects of cocaine
Blocking dopamine receptors in different regions of the amygdala reduces drug seeking and taking behavior with varying longevity, according to research in rats published in eNeuro.
Born to run: just not on cocaine
A study finds a surprising response to cocaine in a novel strain of mutant mice -- they failed to show hyperactivity seen in normal mice when given cocaine and didn't run around.
Cocaine adulterant may cause brain damage
People who regularly take cocaine cut with the animal anti-worming agent levamisole demonstrate impaired cognitive performance and a thinned prefrontal cortex.
Setting affects pleasure of heroin and cocaine
Drug users show substance-specific differences in the rewarding effects of heroin versus cocaine depending on where they use the drugs, according to a study published in JNeurosci.
One in 10 people have traces of cocaine or heroin on their fingerprints
Scientists have found that drugs are now so prevalent that 13 percent of those taking part in a test were found to have traces of class A drugs on their fingerprints -- despite never using them.
Alcohol makes rats more vulnerable to compulsive cocaine use
Rats given alcohol for 10 days prior to cocaine exhibited enhanced cocaine-addiction behavior, including continuing to seek cocaine despite receiving a brief electric shock when they did so, a new study reports.
Cocaine use during adolescence is even more harmful than during adulthood
Brazilian scientists found that addicts who began using cocaine before and after the age of 18 showed differences in sustained attention and working memory, among other brain functions.
Cocaine addiction leads to build-up of iron in brain
Cocaine addiction may affect how the body processes iron, leading to a build-up of the mineral in the brain, according to new research from the University of Cambridge.
More Cocaine News and Cocaine Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Teaching For Better Humans 2.0
More than test scores or good grades–what do kids need for the future? This hour, TED speakers explore how to help children grow into better humans, both during and after this time of crisis. Guests include educators Richard Culatta and Liz Kleinrock, psychologist Thomas Curran, and writer Jacqueline Woodson.
Now Playing: Science for the People

#556 The Power of Friendship
It's 2020 and times are tough. Maybe some of us are learning about social distancing the hard way. Maybe we just are all a little anxious. No matter what, we could probably use a friend. But what is a friend, exactly? And why do we need them so much? This week host Bethany Brookshire speaks with Lydia Denworth, author of the new book "Friendship: The Evolution, Biology, and Extraordinary Power of Life's Fundamental Bond". This episode is hosted by Bethany Brookshire, science writer from Science News.
Now Playing: Radiolab

Space
One of the most consistent questions we get at the show is from parents who want to know which episodes are kid-friendly and which aren't. So today, we're releasing a separate feed, Radiolab for Kids. To kick it off, we're rerunning an all-time favorite episode: Space. In the 60's, space exploration was an American obsession. This hour, we chart the path from romance to increasing cynicism. We begin with Ann Druyan, widow of Carl Sagan, with a story about the Voyager expedition, true love, and a golden record that travels through space. And astrophysicist Neil de Grasse Tyson explains the Coepernican Principle, and just how insignificant we are. Support Radiolab today at Radiolab.org/donate.