Nav: Home

Cell membrane as coating materials to better surface engineering of nanocarriers

May 14, 2019

Surface engineering of nanocarriers devotes considerable contribution to the field of biomedicine ranging from drug delivery to theranostic. Conventional chemical/physical approaches trend to use PEG functionalization, morphological control, and lipid modification, which allow nanocarriers participate various tasks in complex biological conditions. Although the in-vivo performance of nanocarries was improved by using these aforementioned methods, nanocarriers still suffer from drug delivery barrier caused by immune clearance, resulting in a low therapy efficacy. Furthermore, synthetic components of nanocarriers with undesired biocompatibility and biotoxicity also limits their biomedical applications. It is highly needed to develop biomimetic nanocarriers for the current drug delivery systems.

Recently, increase interest inspires that coating cell membranes on the surface of nanocarriers as a promising strategy can help address these issues. Cell membranes isolated from red blood cells are considered as the coating materials on the surface of nanocarriers. This novel bioimimetic hybrid system combines synthetic materials and naturally biological components, which breaks through the traditional concept of nanocarrier. By directly inheriting biological components of cell membrane (proteins, lipids, antigens), nanocarriers successfully achieve the immune-evasion and prolong the circulation time in the blood stream. To pursue functional diversity, some other cells, such as platelets, immune cells, cancer cells, and bacterium, contribute their membranes to cover nanocarriers for versatile properties (Image), including bioadhesion, target recognition, or deep tissue penetration. Compared with synthetic carriers, cell membrane-covered nanocarriers obviously improve their biocompatibility and get great efficiency to perform drug delivery, bioimaging, phototherapy, and detoxification. These above advantages indicate that cell membranes-inspired delivery systems will play an important role in the next-generation nanomedicine with extensive medical applications.

Prof. Junbai Li at Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry?Chinese Academy of Sciences, heads an expertise biomaterial team that develop a series of cell membrane-camouflaged nanocarriers for cancer therapy ranging from drug delivery to photothermal therapy as well as photodynamic therapy. A recent review article published in National Science Review, Prof. Junbai Li's group reviews recent progress of cell membranes-covered nanoparticles from biomaterials perspective, and demonstrate their unique advantages and highlight relevant biomedical applications. The appearance of this review will help researchers of interdisciplinary science to understand cell membrane coating materials, and further promote the development in this field.
See the article:

Mingjun Xuan, Jingxin Shao and Junbai Li
Cell Membrane-Covered Nanoparticles as Biomaterials
Natl Sci Rev (March 2019) doi: 10.1093/nsr/nwz037

The National Science Review is the first comprehensive scholarly journal released in English in China that is aimed at linking the country's rapidly advancing community of scientists with the global frontiers of science and technology. The journal also aims to shine a worldwide spotlight on scientific research advances across China.

Science China Press

Related Cell Membrane Articles:

Proof of sandwiched graphene-membrane superstructure opens up a membrane-specific drug delivery mode
Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences and Tsinghua University (THU) proved a sandwiched superstructure for graphene oxide (GO) that transport inside cell membranes for the first time.
Membrane madness: The ins and outs of moving materials through the cell
The cell membrane is a fatty layer that forms a border between the inside of the cell, its various structures and the outside world.
Cell membrane as coating materials to better surface engineering of nanocarriers
Coating natural cell membranes on synthetic nanocarriers represents an innovative strategy of surface engineering.
Too-tight membrane keeps cells from splitting
Scientists uncover how one protein keeps conditions 'just right' so that cells can easily divide into two identical daughter cells.
How proteins become embedded in a cell membrane
Many proteins with important biological functions are embedded in a biomembrane in the cells of humans and other living organisms.
Drug-induced cellular membrane complexes induce cancer cell death
Biochemistry and Molecular Biology researchers at the Hollings Cancer Center at the Medical University of South Carolina delved into the microscopic world of cell surface sphingolipids and discovered a new sub-cellular complex, as described in the January 2019 issue of Journal of Biological Chemistry.
New transport mechanism of nanomaterial through a cell membrane: membrane stretching
The team of theoretical physics at Universitat Rovira i Virgili in Tarragona, led by Dr.
Clearest view ever of cell membrane yields unexpected structure, research possibilities
Working with a Nobel Prize-winning biophysicist, a team of researchers at Virginia Commonwealth University has gained the clearest view yet of a patch of cell membrane and its components, revealing unexpected structures and opening up new possibilities for pharmaceutical research.
Microbes 'MacGyver' membrane transport
A general concept in biology is that cells use two different systems to transport substances across their membrane: selective pores, which allow passive transport driven by a concentration gradient, and active transport complexes, which use energy to transport substances against a gradient.
Team gets a closer look at how proteins meet on the cell membrane
At last, the researchers have defined the molecular basis of the cell membrane in integrin activation.
More Cell Membrane News and Cell Membrane Current Events

Top Science Podcasts

We have hand picked the top science podcasts of 2019.
Now Playing: TED Radio Hour

Accessing Better Health
Essential health care is a right, not a privilege ... or is it? This hour, TED speakers explore how we can give everyone access to a healthier way of life, despite who you are or where you live. Guests include physician Raj Panjabi, former NYC health commissioner Mary Bassett, researcher Michael Hendryx, and neuroscientist Rachel Wurzman.
Now Playing: Science for the People

#543 Give a Nerd a Gift
Yup, you guessed it... it's Science for the People's annual holiday episode that helps you figure out what sciency books and gifts to get that special nerd on your list. Or maybe you're looking to build up your reading list for the holiday break and a geeky Christmas sweater to wear to an upcoming party. Returning are pop-science power-readers John Dupuis and Joanne Manaster to dish on the best science books they read this past year. And Rachelle Saunders and Bethany Brookshire squee in delight over some truly delightful science-themed non-book objects for those whose bookshelves are already full. Since...
Now Playing: Radiolab

An Announcement from Radiolab