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Complications from thyroid cancer surgery more common than believed, study finds

May 16, 2017

ANN ARBOR, Michigan -- As thyroid cancer rates rise, more people are having surgery to remove all or part of their thyroid. A new study suggests complications from these procedures are more common than previously believed.

Overall, 6.5 percent of thyroid cancer patients had general post-operative complications in the month after surgery, and 12 percent had complications specific to thyroid surgery within the year after their operation. But the risks were significantly higher for certain groups, suggesting the opportunity for targeted interventions and education to improve outcomes.

"That 12 percent of patients overall had thyroid surgery specific complications is concerning. Most of our surgeons quote a 1 to 3 percent rate. This is quadruple what we had thought," says lead study author Maria Papaleontiou, M.D., assistant professor of metabolism, endocrinology and diabetes at Michigan Medicine.

The majority of previous studies on thyroid surgery complications have been from single institutions, often high-volume centers, which are known to have better outcomes.

The new study, published in the Journal of Clinical Endocrinology and Metabolism, looked at 22,867 people who had surgery for thyroid cancer between 1998-2011. Data was collected from the Surveillance, Epidemiology and End Results-Medicare linked database.

Researchers looked at general post-operative complications - fever, infection, blood clots or swelling - that occurred within the first 30 days after surgery. They also looked at complications specific to thyroid surgery, such as hypoparathyroidism, hypocalcemia, and vocal cord or fold paralysis. These conditions can have lifelong impact on patients.

"When we work with patients to treat thyroid cancer, we're always balancing benefits and risks. This study shows there are more complications from surgery for thyroid cancer than expected. It suggests an opportunity to educate both patients and providers to decrease complications and improve outcomes," says senior study author Megan R. Haymart, M.D., assistant professor of metabolism, endocrinology and diabetes at Michigan Medicine.

The researchers identified three groups for which both general and thyroid surgery specific complications were more common:
  • Patients older than 65
  • Patients with more advanced thyroid cancer
  • Patients with other co-existing medical conditions

Older patients were about three times more likely to have complications than those younger than 65. Ten percent of older patients developed general post-operative complications and 19 percent had thyroid surgery-related complications. For patients younger than 65, 3 percent had general complications and 6 percent had thyroid surgery-related complications.

Advanced disease was associated with the highest number of complications: 23 percent of patients whose cancer had spread throughout the body had thyroid surgery specific complications, a number the researchers call "alarming."

"Thyroidectomy is considered a fairly safe operation in general, but some populations are more vulnerable and need extra attention in pre- and post-operative care," Papaleontiou says.

The researchers suggest better educating patients and providers so that those at risk of complications seek out high-volume surgeons that tend to have better outcomes. Other studies have shown that low-volume surgeons perform a disproportionate number of thyroid surgeries in the United States.

In addition, the researchers say it's crucial to educate endocrinologists - who typically treat hypoparathyroidism or hypocalcemia - on the likelihood of these risks on patients who have had thyroid cancer surgery.

In addition, Haymart says conversations about limiting surgery for those with low-risk disease may be appropriate.

"Even in low-risk patients, the risk of vocal cord paralysis is still 2 percent and the risk of hypoparathyroidism is 8 percent. This is higher than we'd like to see," Haymart says. "Are there options to do less extensive surgery for these patients? If the cancer control benefits are similar but the risks of long-term complications would be less, we need to provide patients with this option."
-end-
Papaleontiou and Haymart are both members of the University of Michigan Comprehensive Cancer Center and the Institute for Healthcare Policy and Innovation.

Additional authors: David T. Hughes, M.D.; Cui Guo, M.S.; Mousumi Banerjee, Ph.D.

Funding: National Institute on Aging grant K08 AG049684, National Cancer Institute grant R01 CA201198, Agency for Healthcare Research and Quality grant R01 HS024512

Disclosure: None

Reference: Journal of Clinical Endocrinology and Metabolism, doi.org/10.1210/jc.2017-00255, published online April 28, 2017

Resources:

University of Michigan Comprehensive Cancer Center, http://www.mcancer.org
Michigan Medicine Cancer AnswerLine, 800-865-1125
Michigan Health Lab, http://www.MichiganHealthLab.org

Michigan Medicine - University of Michigan

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