Nav: Home

A stress response protein may prevent kidney damage after heart surgery

May 16, 2018

Researchers have discovered that elevated levels of a stress response protein are associated with a reduced risk of kidney damage after heart surgery in patients. Their preliminary analysis of 60 patients has implications for the development of new therapies and risk management strategies to reduce the likelihood of severe kidney complications stemming from invasive cardiac procedures. The most common complication from open-heart surgery is acute kidney injury (or AKI), which occurs when the patient's kidneys suddenly fail to filter waste products. AKI worsens patient outcomes and extends the length of hospital stays, resulting in significantly higher healthcare costs. Scientists previously found that a cell signaling molecule named macrophage migration inhibitory factor (MIF) protects the heart from damage induced by fluctuating oxygen levels, leading Christian Stoppe and colleagues to suspect that MIF could also mitigate damage to other organs such as the kidneys. They measured the concentrations of MIF in serum and urine samples taken from patients at several time points before and after heart surgery. The authors found that patients with high levels of MIF in serum 12 hours after surgery were less likely to develop AKI compared to individuals with lower MIF levels. Furthermore, removing the gene that encodes for MIF resulted in increased death of kidney cells in mouse models of AKI. Administering MIF both before and after blocking blood flow to the kidneys also ameliorated AKI in wild type mice. The study does not prove a causative effect, and larger clinical studies should validate the clinical significance of circulating MIF as a potentially effective tool to identify patients at risk for AKI.

American Association for the Advancement of Science

Related Heart Surgery Articles:

All heart patients have some liver disease after Fontan surgery
Patients who undergo the Fontan operation as children for a complex congenital heart defect are at risk of developing progressive liver fibrosis, a buildup of fibrous deposits, as a result of the circulation created by the surgery.
Blood test can detect heart damage after non-cardiac surgery
A blood test for a protein called high-sensitivity troponin T, which is released into the bloodstream when injury to the heart occurs, can identify patients with heart damage after non-cardiac surgery whose lives could potentially be saved with timely treatment, according to research presented at the American College of Cardiology's 66th Annual Scientific Session.
Bariatric surgery may reduce heart failure risk
Bariatric surgery and other treatments that cause substantial weight loss can significantly reduce the risk of heart failure in obese patients.
Heart injury reduced after bariatric surgery but not lifestyle intervention
Heart function in morbidly obese patients returns to normal after bariatric surgery but not after lifestyle intervention, reveals research published today in the European Journal of Preventive Cardiology.
Transfusion with stored blood safe in heart surgery
A large registry study led from Sweden's Karolinska Institutet shed new light on the much debated issue of transfusions with stored blood.
Dexamethasone may help prevent severe kidney injury following heart surgery
Patients who received dexamethasone during heart surgery had about a 2.5-times lower risk of developing kidney failure requiring dialysis compared with those receiving a placebo.
Blood markers could help predict outcome of infant heart surgery
New research suggests it may be possible to predict an infant's progress following surgery for congenital heart disease by analyzing a number of important small molecules in the blood.
Blood test can help identify stroke risk following heart surgery
The results of a blood test done immediately after heart surgery can be a meaningful indicator of postoperative stroke risk, a study by researchers at Wake Forest Baptist Medical Center has found.
Heart bypass surgery outperforms new generation stents
Despite the advent of a new generation of stents, patients with multiple narrowed arteries in the heart who received coronary artery bypass grafting fared better than those whose arteries were opened with balloon angioplasty and stents in a study presented at the American College of Cardiology's 64th Annual Scientific Session.
New data suggest little benefit of adding heart valve repair to bypass surgery in patients with coronary heart disease
The Cardiothoracic Surgical Trials Network is reporting results for the first time from a clinical trial of patients who have a complication of coronary heart disease known as moderate ischemic mitral regurgitation.

Related Heart Surgery Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Failure can feel lonely and final. But can we learn from failure, even reframe it, to feel more like a temporary setback? This hour, TED speakers on changing a crushing defeat into a stepping stone. Guests include entrepreneur Leticia Gasca, psychology professor Alison Ledgerwood, astronomer Phil Plait, former professional athlete Charly Haversat, and UPS training manager Jon Bowers.
Now Playing: Science for the People

#524 The Human Network
What does a network of humans look like and how does it work? How does information spread? How do decisions and opinions spread? What gets distorted as it moves through the network and why? This week we dig into the ins and outs of human networks with Matthew Jackson, Professor of Economics at Stanford University and author of the book "The Human Network: How Your Social Position Determines Your Power, Beliefs, and Behaviours".