Mindfulness training shows promise for people with MS

May 18, 2020

COLUMBUS, Ohio - New research suggests mindfulness training may help multiple sclerosis patients in two very different ways: regulating negative emotions and improving processing speed.

People with MS who underwent the four-week mindfulness training not only improved more compared to those who did nothing - they also improved compared to those who tried another treatment, called adaptive cognitive training.

"This was a small pilot study, so we need to replicate the results, but these findings were very encouraging," said Ruchika Prakash, corresponding author of the research and associate professor of psychology at The Ohio State University.

"It is exciting to find a treatment that may be helpful in more than one way for people with multiple sclerosis."

The findings were published recently in two journal articles: primary results in Rehabilitation Psychology, and secondary analysis in Neuropsychology.

Multiple sclerosis is the most common neurological disease in young adults and is estimated to affect nearly 1 million people in the United States. It damages the central nervous system and can lead to a variety of physical, emotional and cognitive problems.

The study involved 61 people with MS who were placed in one of three groups: four-week mindfulness training, four-week adaptive cognitive training, or a waitlist control group that did nothing during the study period, but received treatment afterward.

Mindfulness-based training involves practicing paying attention to the present moment in a nonjudgmental and accepting manner, Prakash said. Among the practices in the sessions, participants learned how to focus on the breath and to do mental "body scans" to experience how their body was feeling.

In the primary analysis of the study, led by former doctoral student Brittney Schirda, the researchers wanted to find out if mindfulness training helped multiple sclerosis patients deal with a common component of the disease: problems regulating their emotions.

"Studies suggest that 30 to 50 percent of MS patients experience some form of psychiatric disorder," Prakash said. "Anything we can do to help them cope is important for their quality of life."

Study participants completed a measure of emotional regulation at the beginning and end of the study. They were asked how much they agreed with questions like "When I'm upset, I lose control over my behavior" and "I experience my emotions as overwhelming and out of control."

Results showed that people in the mindfulness training group reported they were more able to manage their emotions at the end of the study when compared to those in the other two groups.

This included the group that received adaptive cognitive training (ACT), which has shown promise for MS patients in other studies. This ACT program used computerized games to help MS patients overcome some of their cognitive deficits that make everyday functioning more difficult, such as problems with paying attention, switching focus, and planning and organizing.

"Our results provide promising evidence that mindfulness training can help MS patients deal with their emotions in a more constructive and positive way," Prakash said.

In a secondary analysis of the same study, led by doctoral student Heena Manglani, participants were assessed on their processing speed and working memory, two cognitive functions that often decline in MS patients. They also completed additional measures of cognitive functioning.

Processing speed is the time it takes a person to complete mental tasks and is related to how well they can understand and react to the information they receive.

Findings showed that after four weeks of mindfulness training, MS patients showed significantly improved processing speed based on the tests used in the study - more so than those in the other two groups.

"This is an exciting finding because processing speed is a core cognitive domain impacted in multiple sclerosis," Prakash said.

"We were somewhat surprised that this training intervention that we thought would mostly impact emotion regulation also enhanced processing speed."

Gains in working memory were similar in all three groups and there were no mindfulness-specific changes in other measures of cognitive functioning.

One of the reasons that mindfulness training is so promising is because it is an easily accessible treatment for all patients.

"Anyone can use mindfulness - even individuals with limited mobility, who often find other training techniques, like exercise training, to be more challenging," Prakash said.

Prakash and her team are now working on replicating this pilot study with a larger sample.
-end-
The research was supported by the National Multiple Sclerosis Society.

Other co-authors on the emotion dysregulation paper were Manglani, Elizabeth Duraney, Rebecca Andridge and Andre Plate of Ohio State; Jacqueline Nicholas of the Ohio Health Multiple Sclerosis Center; and H. Kyu Lee of Posit Science.

Co-authors on the processing speed study were Shaadee Samimy of Ohio State and Schirda and Nicholas.

Contact: Ruchika Prakash, Prakash.30@osu.edu

Written by Jeff Grabmeier, 614-292-8457; Grabmeier.1@osu.edu

Ohio State University

Related Multiple Sclerosis Articles from Brightsurf:

New therapy improves treatment for multiple sclerosis
A new therapy that binds a cytokine to a blood protein shows potential in treating multiple sclerosis, and may even prevent it.

'Reelin' in a new treatment for multiple sclerosis
In an animal model of multiple sclerosis (MS), decreasing the amount of a protein made in the liver significantly protected against development of the disease's characteristic symptoms and promoted recovery in symptomatic animals, UTSW scientists report.

Not all multiple sclerosis-like diseases are alike
Scientists say some myelin-damaging disorders have a distinctive pathology that groups them into a unique disease entity.

New therapeutic options for multiple sclerosis in sight
Strategies for treating multiple sclerosis have so far focused primarily on T and B cells.

Diet has an impact on the multiple sclerosis disease course
The short-chain fatty acid propionic acid influences the intestine-mediated immune regulation in people with multiple sclerosis (MS).

The gut may be involved in the development of multiple sclerosis
It is incompletely understood which factors in patients with multiple sclerosis act as a trigger for the immune system to attack the brain and spinal cord.

Slowing the progression of multiple sclerosis
Over 77,000 Canadians are living with multiple sclerosis, a disease whose causes still remain unknown.

7T MRI offers new insights into multiple sclerosis
Investigators from Brigham and Women's Hospital have completed a new study using 7 Tesla (7T) MRI -- a far more powerful imaging technology -- to further examine LME in MS patients

How to improve multiple sclerosis therapy
Medications currently used to treat multiple sclerosis (MS) can merely reduce relapses during the initial relapsing-remitting phase.

Vaccinations not a risk factor for multiple sclerosis
Data from over 12,000 multiple sclerosis (MS) patients formed the basis of a study by the Technical University of Munich (TUM) which investigated the population's vaccination behavior in relation to MS.

Read More: Multiple Sclerosis News and Multiple Sclerosis Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.