Nav: Home

Flies the key to studying the causes of dementia

May 19, 2017

A research team from the University of Plymouth, University of Southampton and the Alexander Fleming Biomedical Sciences Research Center, Vari, Greece, have studied two structurally-similar proteins in the adult brain and have found that they play distinct roles in the development of dementia.

Their study is published in the prestigious journal Neurobiology of Disease.

The understanding and knowledge gained from this study could lead to effective therapies for dementia and other neurodegenerative diseases.

Tau proteins stabilise microtubules in the brain and nervous system. Microtubules help form the structure of cells and other functions, such as providing the rail tracks for transport between cells.

In the brain of dementia patients, the abnormal clumping of Tau proteins have long been linked to changes in nerve cell activation and ultimately cell death. Two structurally different forms of Tau exist. The research team expressed these two forms of human Tau in nerve cells of the Drosophila (fruit fly) brain, examining their effects on nerve cell survival and activation, fly movement and memory formation.

The results show that these two proteins differ in terms of biology and pathological potential. One leads to poor communication between nerves associated with movement. The other leads to greater neurodegeneration and impairments in learning and memory.

This is important because defects in the proteins have a bearing on neurodegenerative diseases such as dementia. Designing drugs which target each form specifically should help to improve specific symptoms.

Involved in the study from the University of Plymouth is Dr Torsten Bossing. He commented: "With each new discovery like this we move one step closer to finding effective drug treatments for debilitating neurodegenerative diseases. This is an important study carried out using nerve cells from fruit flies and it has the potential over the coming years to be developed through more testing and clinical trials. We firmly believe that the answer to the question of how we treat conditions such as dementia lies at this cellular level."
-end-
The study received funding from the Royal Society (Plymouth), the Wessex Medical Trust and Gerald Kerkut Trust (Southampton), and the European Social Fund and Greek National Funds (THALIS-UOA) (Vari).

University of Plymouth

Related Dementia Articles:

Flies the key to studying the causes of dementia
A research team from the University of Plymouth, University of Southampton and the Alexander Fleming Biomedical Sciences Research Center, Vari, Greece, have studied two structurally-similar proteins in the adult brain and have found that they play distinct roles in the development of dementia.
Stroke prevention may also reduce dementia
Ontario's stroke prevention strategy appears to have had an unexpected, beneficial side effect: a reduction also in the incidence of dementia among older seniors.
Dementia: The right to rehabilitation
Rehabilitation is important for people with dementia as it is for people with physical disabilities, according to a leading dementia expert.
One in 4 elderly Australian women have dementia
At least a quarter of Australian women over 70 will develop dementia according to University of Queensland researchers.
Rural dementia -- we need to talk
Research carried out by Plymouth University into the experience of dementia in farming and farming families, and its impact on their businesses and home lives, has identified four areas of concern which need to be addressed if dementia in the countryside is to be managed.
Women with dementia receive less medical attention
Women with dementia have fewer visits to the GP, receive less health monitoring and take more potentially harmful medication than men with dementia, new UCL research reveals.
Dementia on the downslide, especially among people with more education
In a hopeful sign for the health of the nation's brains, the percentage of American seniors with dementia is dropping, a new study finds.
New study suggests rethink of dementia causes
University of Adelaide researchers have developed a new theory for the causes of dementia and other neurodegenerative diseases, involving an out-of-control immune system.
Bleeding stroke associated with onset of dementia
Bleeding within the brain, or intracerebral hemorrhage, was associated with a high risk of developing dementia post stroke, according to research presented at the American Stroke Association's International Stroke Conference 2016.
Dementia: New insights into causes of loss of orientation
The University of Exeter Medical School led two studies, each of which moves us a step closer to understanding the onset of dementia, and potentially to paving the way for future therapies.

Related Dementia Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Anthropomorphic
Do animals grieve? Do they have language or consciousness? For a long time, scientists resisted the urge to look for human qualities in animals. This hour, TED speakers explore how that is changing. Guests include biological anthropologist Barbara King, dolphin researcher Denise Herzing, primatologist Frans de Waal, and ecologist Carl Safina.
Now Playing: Science for the People

#SB2 2019 Science Birthday Minisode: Mary Golda Ross
Our second annual Science Birthday is here, and this year we celebrate the wonderful Mary Golda Ross, born 9 August 1908. She died in 2008 at age 99, but left a lasting mark on the science of rocketry and space exploration as an early woman in engineering, and one of the first Native Americans in engineering. Join Rachelle and Bethany for this very special birthday minisode celebrating Mary and her achievements. Thanks to our Patreons who make this show possible! Read more about Mary G. Ross: Interview with Mary Ross on Lash Publications International, by Laurel Sheppard Meet Mary Golda...