Personalised ovarian cancer risk prediction reduces worries

May 19, 2020

Offering personalised ovarian cancer risk prediction to women shows that 98 per cent of participants felt less worried after finding out their ovarian cancer risk status, according to a study led by Queen Mary University of London.

Identifying women at high risk for ovarian cancer currently relies on clinical assessments and family history-based testing for susceptibility genes - a policy that misses more than half of the gene carriers and represents enormous missed opportunities for more targeted prevention. Around 70 per cent of ovarian cancer cases are currently diagnosed too late, when they are already at stage 3 or 4, meaning that treatment is more radical and the chance of survival is much lower, compared to being diagnosed at stage 1 or 2.

In the study, funded by Cancer Research UK and The Eve Appeal, volunteers completed a risk assessment and genetic testing to receive a personalised risk estimate of developing ovarian cancer, which was calculated using genetic, lifestyle and hormonal ovarian cancer risk factors. None of the participants would routinely have been offered genetic testing on the NHS, as they did not fulfil current clinical testing criteria.

The study then followed the participants over six months through questionnaires which recorded a range of information including their psychological health and quality of life. Ovarian cancer worry and general cancer risk perception decreased over the six months. Individuals identified at increased risk could opt for screening and prevention.

The results suggest that this population-based personalised risk prediction is feasible and acceptable, has high satisfaction, reduces cancer worry, and does not have a negative impact on psychological health or quality of life.

Lead researcher Professor Ranjit Manchanda from Queen Mary's Barts Cancer Institute and Wolfson Institute of Preventive Medicine said: "Our findings support broadening genetic testing for ovarian cancer genes across the entire population, beyond just the current criteria-based approach, to better identify women at risk. This could prevent thousands more cancers than any current strategy, saving many lives. Why do we need to wait for women to get cancer to identify others in whom we can prevent cancer? A population testing approach can change this."

Professor Ian Jacobs from University of New South Wales said: "If women identified as high risk act on the information that they're given they can take preventative action to reduce their risk or undertake regular screening. The impact that this study could have on healthcare in the future for these cancers is promising and an exciting step forward in prevention."

Athena Lamnisos, CEO of The Eve Appeal added: "At The Eve Appeal we know that investing in cancer prevention is so vital. It's much better to prevent cancer development than deal with the devastating consequences of a cancer diagnosis. Particularly for a disease that's often diagnosed at a late stage like ovarian cancer. This pilot trial shows promise for all women. The emerging evidence shows that it could provide a personalised estimate of their risk of ovarian cancer development. This will allow them to make decisions allowing them to minimise their risk, by opting for preventative surgery, or to have regular screening. An exciting step forward."
-end-
The study involved colleagues from University College London, University of Cambridge, King's College London, Birmingham Women's NHS Foundation Trust, Manchester Centre for Genomic Medicine, London School of Hygiene and Tropical Medicine, Southampton University Hospital and University of New South Wales.

For more information, please contact:

Joel Winston
Communications Manager (School of Medicine and Dentistry)
Queen Mary University of London
j.winston@qmul.ac.uk
Tel: +44 (0)7968 267 064

Notes to the editor

Research paper: 'Population Study of Ovarian Cancer Risk Prediction for Targeted Screening and Prevention'. Cancers 2020, 12(5), 1241. Available here: https://www.mdpi.com/2072-6694/12/5/1241/htm

About Queen Mary University of London

At Queen Mary University of London, we believe that a diversity of ideas helps us achieve the previously unthinkable.

In 1785, Sir William Blizard established England's first medical school, The London Hospital Medical College, to improve the health of east London's inhabitants. Together with St Bartholomew's Medical College, founded by John Abernethy in 1843 to help those living in the City of London, these two historic institutions are the bedrock of Barts and The London School of Medicine and Dentistry.

Today, Barts and The London continues to uphold this commitment to pioneering medical education and research. Being firmly embedded within our east London community, and with an approach that is driven by the specific health needs of our diverse population, is what makes Barts and The London truly distinctive.

Our local community offer to us a window to the world, ensuring that our ground-breaking research in cancer, cardiovascular and inflammatory diseases, and population health not only dramatically improves the outcomes for patients in London, but also has a far-reaching global impact.

This is just one of the many ways in which Queen Mary is continuing to push the boundaries of teaching, research and clinical practice, and helping us to achieve the previously unthinkable.

Queen Mary University of London

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