U of MN will lead national research study on causes of bone cancer in children

May 21, 2007

Logan Spector, Ph.D., a University of Minnesota Cancer Center researcher, has received a $1.7 million grant from the National Cancer Institute (NCI) to lead the largest and most comprehensive study to date on the causes of pediatric osteosarcoma.

Osteosarcoma is a cancer of the bone that usually affects the long bones of the arm or leg. It is the most common cancer of the bone in children under 20 years of age in the United States. Each year about 400 children are diagnosed with the disease.

Spector is an assistant professor of pediatrics at the University of Minnesota Medical School and Cancer Center. The University of Minnesota is a national research and treatment site for children with bone cancer. This four-year research study will include 500 children in the United States and Canada who have been diagnosed with osteosarcoma. Their parents also will be enrolled in the study.

"Previous research has shown a close correlation between the childhood growth curve and osteosarcoma," Spector says. "Children with a more rapid or sustained growth spurt may have a higher risk of osteosarcoma.

"Our research will investigate the effects of genes related to bone growth to determine if they have a role in causing this cancer." Spector says. "We think there could be a link between bone growth genes and osteosarcoma because the timing and extent of adolescent bone growth are mostly genetic. "We also will study how well the cells repair DNA damage naturally, and if the genes are impacted by diet, physical activity, family health history, and other lifestyle-related habits."

A DNA sample will be obtained from each child with osteosarcoma as well as from the parents to learn if the children inherited these bone growth genes more or less often than expected. Growth records of children with the disease will also be compared to national standards, and all participants will complete a questionnaire about their family history and lifestyle.
-end-
Spector will work with other pediatric cancer researchers at the University of Minnesota; The Hospital for Sick Children in Toronto, Canada; Cincinnati Children's Hospital Medical Center in Cincinnati, Ohio; Memorial Sloan-Kettering Cancer Center in New York; and the NCI. The Twin Cities-based Children's Cancer Research Fund and the Karen Wyckoff Rein in Sarcoma Fund provided funding for the preliminary study.

For more information about pediatric osteosarcoma and this research study, contact the University of Minnesota Cancer Center's Information Line at 612-624-2620 or visit www.cancer.umn.edu.

University of Minnesota

Related Cancer Articles from Brightsurf:

New blood cancer treatment works by selectively interfering with cancer cell signalling
University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published in Nature Communications.

UCI researchers uncover cancer cell vulnerabilities; may lead to better cancer therapies
A new University of California, Irvine-led study reveals a protein responsible for genetic changes resulting in a variety of cancers, may also be the key to more effective, targeted cancer therapy.

Breast cancer treatment costs highest among young women with metastic cancer
In a fight for their lives, young women, age 18-44, spend double the amount of older women to survive metastatic breast cancer, according to a large statewide study by the University of North Carolina at Chapel Hill.

Cancer mortality continues steady decline, driven by progress against lung cancer
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported.

Stress in cervical cancer patients associated with higher risk of cancer-specific mortality
Psychological stress was associated with a higher risk of cancer-specific mortality in women diagnosed with cervical cancer.

Cancer-sniffing dogs 97% accurate in identifying lung cancer, according to study in JAOA
The next step will be to further fractionate the samples based on chemical and physical properties, presenting them back to the dogs until the specific biomarkers for each cancer are identified.

Moffitt Cancer Center researchers identify one way T cell function may fail in cancer
Moffitt Cancer Center researchers have discovered a mechanism by which one type of immune cell, CD8+ T cells, can become dysfunctional, impeding its ability to seek and kill cancer cells.

More cancer survivors, fewer cancer specialists point to challenge in meeting care needs
An aging population, a growing number of cancer survivors, and a projected shortage of cancer care providers will result in a challenge in delivering the care for cancer survivors in the United States if systemic changes are not made.

New cancer vaccine platform a potential tool for efficacious targeted cancer therapy
Researchers at the University of Helsinki have discovered a solution in the form of a cancer vaccine platform for improving the efficacy of oncolytic viruses used in cancer treatment.

American Cancer Society outlines blueprint for cancer control in the 21st century
The American Cancer Society is outlining its vision for cancer control in the decades ahead in a series of articles that forms the basis of a national cancer control plan.

Read More: Cancer News and Cancer Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.