Angiotensin II shows promise in helping critically ill patients with low blood pressure

May 21, 2017

Sixty years after Cleveland Clinic researchers first isolated the role of angiotensin II in controlling blood pressure, a new international study led by Cleveland Clinic researchers shows that the compound can safely improve blood pressure among critically ill patients who are experiencing life-threatening hypotension, or low blood pressure.

The research - led by Ashish Khanna, M.D., an intensivist and anesthesiologist in Cleveland Clinic's Center for Critical Care - will be published online by the New England Journal of Medicine, in conjunction with the American Thoracic Society's special session on clinical research.

"Vasodilatory shock - in which a patient's blood pressure drops and blood vessels dilate - is a serious concern for ICU patients. When the condition is not responsive to high-dose vasopressors like norepinephrine and vasopressin, it is associated with high mortality, with more than half of these patients dying within 30 days," Dr. Khanna said. "We found that angiotensin II is an effective intervention for these patients, significantly increasing blood pressure in this life-threatening situation. The drug was safe and well-tolerated and also showed a trend to decreased mortality, though this did not achieve clinical significance."

The study enrolled 321 patients - 163 treated with angiotensin II and 158 with placebo - who were experiencing vasodilatory shock and had received high doses of conventional vasopressors.

Angiotensin II significantly improved hypotension (low blood pressure) - increasing mean arterial pressure at 3 hours - compared with placebo; nearly 70 percent of angiotensin II-treated patients (114 of 163) saw improved blood pressure compared with 23 percent of the placebo group (37 of 158 patients).

The trial was conducted in 75 intensive care units across nine countries in North America, Australia and Europe.

Angiotensin II was first isolated at Cleveland Clinic in the 1950s by Irvine Page, M.D., who discovered that the substance in blood causes blood vessels to constrict and blood pressure to rise. Along with co-researcher F. Merlin Bumpus, Ph.D., Page synthesized the peptide in 1957, helping to shape medicine's understanding of blood pressure and heart disease. For the first time, high blood pressure was viewed as a condition that could be treated, by blocking the body's production on angiotensin II.

In this new research, the goal was to raise blood pressure in critically ill patients in vasodilatory shock by providing exogenous Angiotensin II. It is the first and largest phase III randomized controlled trial of stable, synthetic human angiotensin II.

It was conducted under a special protocol assessment with the US Food and Drug Administration, which considers an uncompleted Phase III trial's design, clinical endpoints, and statistical analyses acceptable for FDA approval.
The study was funded by La Jolla Pharmaceutical Inc. ( number NCT02338843) and completed with internal support from the Department of Outcomes Research, and the Anesthesiology Institute at the Cleveland Clinic.

About Cleveland Clinic

Cleveland Clinic is a nonprofit multispecialty academic medical center that integrates clinical and hospital care with research and education. Located in Cleveland, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. Cleveland Clinic has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States. U.S. News & World Report consistently names Cleveland Clinic as one of the nation's best hospitals in its annual "America's Best Hospitals" survey. Among Cleveland Clinic's 51,000 employees are more than 3,500 full-time salaried physicians and researchers and 14,000 nurses, representing 140 medical specialties and subspecialties. Cleveland Clinic's health system includes a 165-acre main campus near downtown Cleveland, 10 regional hospitals, more than 150 northern Ohio outpatient locations - including 18 full-service family health centers and three health and wellness centers - and locations in Weston, Fla.; Las Vegas, Nev.; Toronto, Canada; Abu Dhabi, UAE; and London, England. In 2016, there were 7.1 million outpatient visits, 161,674 hospital admissions and 207,610 surgical cases throughout Cleveland Clinic's health system. Patients came for treatment from every state and 185 countries. Visit us at Follow us at News and resources available at

Cleveland Clinic

Related Blood Pressure Articles from Brightsurf:

Children who take steroids at increased risk for diabetes, high blood pressure, blood clots
Children who take oral steroids to treat asthma or autoimmune diseases have an increased risk of diabetes, high blood pressure, and blood clots, according to Rutgers researchers.

High blood pressure treatment linked to less risk for drop in blood pressure upon standing
Treatment to lower blood pressure did not increase and may decrease the risk of extreme drops in blood pressure upon standing from a sitting position.

Changes in blood pressure control over 2 decades among US adults with high blood pressure
National survey data were used to examine how blood pressure control changed overall among U.S. adults with high blood pressure between 1999-2000 and 2017-2018 and by age, race, insurance type and access to health care.

Transient increase in blood pressure promotes some blood vessel growth
Blood vessels are the body's transportation system, carrying oxygen and nutrients to cells and whisking away waste.

Effect of reducing blood pressure medications on blood pressure control in older adults
Whether the amount of blood pressure medications taken by older adults could be reduced safely and without a significant change in short-term blood pressure control was the objective of this randomized clinical trial that included 534 adults 80 and older.

Brain blood flow sensor discovery could aid treatments for high blood pressure & dementia
A study led by researchers at UCL has discovered the mechanism that allows the brain to monitor its own blood supply, a finding in rats which may help to find new treatments for human conditions including hypertension (high blood pressure) and dementia.

Here's something that will raise your blood pressure
The apelin receptor (APJ) has been presumed to play an important role in the contraction of blood vessels involved in blood pressure regulation.

New strategy for treating high blood pressure
The key to treating blood pressure might lie in people who are 'resistant' to developing high blood pressure even when they eat high salt diets, shows new research published today in Experimental Physiology.

Arm cuff blood pressure measurements may fall short for predicting heart disease risk in some people with resistant high blood pressure
A measurement of central blood pressure in people with difficult-to-treat high blood pressure could help reduce risk of heart disease better than traditional arm cuff readings for some patients, according to preliminary research presented at the American Heart Association's Hypertension 2019 Scientific Sessions.

Heating pads may lower blood pressure in people with high blood pressure when lying down
In people with supine hypertension due to autonomic failure, a condition that increases blood pressure when lying down, overnight heat therapy significantly decreased systolic blood pressure compared to a placebo.

Read More: Blood Pressure News and Blood Pressure Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to