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First-of-its-kind study finds positive outcomes for chronic kidney disease patients

May 21, 2019

First-Of-Its-Kind Study Finds Positive Outcomes For Chronic Kidney Disease Patients Treated With Intravascular Ultrasound Guided Drug Eluting Stents Implantations

LAS VEGAS (MAY 21, 2019) - A new study exams the effects of intravascular ultrasound (IVUS) guided drug-eluting stent (DES) implantation on patients with Chronic Kidney Disease (CKD). Results showed that CKD patients treated with IVUS-guided DES implantation had better outcomes compared to those who received the traditional angiography guidance DES implantation at the 12-month mark. The prespecific subgroup analysis of the prospective, multicenter, randomized ULTIMATE trial is scheduled to be presented on Wednesday, May 22 as late-breaking clinical research at the Society for Cardiovascular Angiography and Interventions (SCAI) 2019 Scientific Sessions.

Chronic kidney disease is a growing worldwide health issue affecting one in ten individuals, according to the National Kidney Foundation. Patients with CKD are more than 30 percent likely to have cardiovascular disease which is the leading cause of death, according to the National Institutes of Health. While several randomized trials and observational studies have established the clinical benefits of IVUS-guided DES implantations for patients with complex lesions, the treatment option remains controversial for patients with CKD due to longer procedural time and perceived potential risks of acute renal failure and atheroembolism.

"The present study, which was a prespecified subgroup analysis of the ULTIMATE trial, was designed to explore the impacts of IVUS-guided second-generation DES implantations on patients with CKD." said Junjie Zhang, MD, PhD, Nanjing First Hospital, Nanjing Medical University, China. "The results from our study show that compared to angiography guidance procedures, IVUS-guided DES implantation is a new and effective treatment approach. This procedure has the potential to significantly decrease target vessel failure in CKD patients and, ultimately, improve their quality of life."

The study assessed 1,443 patients of whom 723 underwent IVUS-guided DES implantations and 720 underwent angiography-guided DES implantations from August 2014 to May 2017. The inclusion criteria were patients who had silent ischemia, stable or unstable angina, or myocardial infarctions from the onset of chest pain to admission, as well as de novo coronary lesions that were eligible for DES implantation. The trial was conducted in eight hospitals throughout China and was approved at each participating center. CKD was present in 349 (24.2 percent) patients. CKD patients were older and more frequently presented with a history of stroke, hypertension, symptomatic heart failure (HF), and lower left ventricular ejection fraction (LVEF).

At 12 months, the target vessel failure (TVF) in the CKD group was 7.2 percent, significantly higher than 3.2 percent in the non-CKD group, which was mainly driven by increased risk of cardiac death in CKD patients, compared to non-CKD patients (2.9 percent vs. 0.5 percent). Moreover, there were 25 TVFs in CKD patients, with seven TVFs (3.9 percent) in the IVUS group and 18 TVFs (10.7 percent) in the angiography group. The reduced risk of TVF in the IVUS group for CKD patients was mainly driven by the lower risk of Target Vessel MI (TVMI) (0.6 percent vs. 3.6 percent) and Target Vessel Revascularization (TVR) (1.1 percent vs. 4.7 percent).

To further assess long-term efficacy of IVUS-guided DES implantation as a treatment option, the authors of this study call for a broader randomized trial.
Session Details:

"Featured Clinical Research, Part II: "Impact of Intravascular ultrasound-guided drug-eluting stent implantation on patients with chronic kidney disease: results from ULTIMATE trial" [May 22, 2019 11:30 a.m. - 11:40 a.m. PDT, Belmont Ballroom 4]

About SCAI:

The Society for Cardiovascular Angiography and Interventions is a 5,000-member professional organization representing invasive and interventional cardiologists in approximately 75 nations. SCAI's mission is to promote excellence in invasive/interventional cardiovascular medicine through physician education and representation, and advancement of quality standards to enhance patient care.

For more information about the SCAI 2019 Scientific Sessions, visit Follow @SCAI on Twitter for the latest heart health news and use #SCAI2019 to follow the latest discussions.

Society for Cardiovascular Angiography and Interventions

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