Dawn-to-sunset fasting suggests potential new treatment for obesity-related conditions

May 21, 2019

San Diego, CA (May 21, 2019) -- Fasting from dawn to sunset for 30 days increased levels of proteins that play a crucial role in improving insulin resistance and protecting against the risks from a high-fat, high-sugar diet, according to research presented at Digestive Disease Week® (DDW) 2019. The study, which was based on the fasting practices of Ramadan, a spiritual practice for Muslims, offers a potential new treatment approach for obesity-related conditions, including diabetes, metabolic syndrome and non-alcoholic fatty liver disease (NAFLD).

"According to World Health Organization data, obesity affects over 650 million people worldwide, placing them at risk for any number of health conditions," said Ayse Leyla Mindikoglu, MD, MPH, lead author of the study and associate professor of medicine and surgery at Baylor College of Medicine, Texas. "Feeding and fasting can significantly impact how the body makes and uses proteins that are critical to decreasing insulin resistance and maintaining a healthy body weight. Therefore, the timing of and duration between meals could be important factors to consider for people struggling with obesity-related conditions."

The pilot study included 14 healthy individuals who fasted (no food or drink) approximately 15 hours a day from dawn to sunset for 30 days during Ramadan. Researchers collected blood samples from the individuals before beginning the religious fast, again at the fourth week of fasting, and then one-week post-fasting. Resulting blood samples showed increased levels of tropomyosin (TPM) 1, 3 and 4, proteins that have a role in maintaining healthy cells and cell repairs important to the body's response to insulin.

TPM3 plays a key role in increasing insulin sensitivity, which allows the cells of the body to use blood glucose more effectively, reducing blood sugar. Findings from the study showed a significant increase in TPM3 gene protein products between the initiation of the fast and the test one week afterwards. Similar results over that period were found for TPM1 and TPM4 gene protein products.

"We are in the process of expanding our research to include individuals with metabolic syndrome and NAFLD to determine whether results are consistent with those of the healthy individuals," said Dr. Mindikoglu. "Based on our initial research, we believe that dawn-to-sunset fasting may provide a cost-effective intervention for those struggling with obesity-related conditions."
-end-
This work is partly supported by NIH Public Health Service grant P30DK056338, which funds the Texas Medical Center Digestive Diseases Center and its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Institute of Diabetes and Digestive and Kidney Diseases or the National Institutes of Health (NIH). This work is also partly supported by a Dora Roberts Foundation Grant and an unrestricted gift for direct clinical research from David R. and Gladys P. Laws.

DDW Presentation Details

Dr. Mindikoglu will present data from the study, "Dawn to sunset fasting for 30 days induces tropomyosin 1, 3 and 4 genes in healthy volunteers: its clinical implications in metabolic syndrome and non-alcoholic fatty liver disease," abstract 951b, on Tuesday, May 21, at 10:15 a.m. PDT. For more information about featured studies, as well as a schedule of availability for featured researchers, please visit http://www.ddw.org/press.

Digestive Disease Week® (DDW) is the largest international gathering of physicians, researchers and academics in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. Jointly sponsored by the American Association for the Study of Liver Diseases (AASLD), the American Gastroenterological Association (AGA) Institute, the American Society for Gastrointestinal Endoscopy (ASGE) and the Society for Surgery of the Alimentary Tract (SSAT), DDW takes place May 18-21, 2019, in San Diego, California. The meeting showcases more than 5,000 abstracts and hundreds of lectures on the latest advances in GI research, medicine and technology. More information can be found at http://www.ddw.org.

Digestive Disease Week

Related Metabolic Syndrome Articles from Brightsurf:

Metabolic syndrome linked to worse outcomes for COVID-19 patients
Patients hospitalized with COVID-19 who had a combination of high blood pressure, obesity and diabetes were over three times more likely to die from the disease, according to a new Tulane University study published in Diabetes Care.

New study finds that menopause increases risk of metabolic syndrome
Perimenopause is a time when women become more vulnerable to a number of health problems.

Does sarcoponic obesity link to metabolic syndrome? An issue that needs clarification
A systematic review and meta-analysis with the main scope to provide benchmark data on the prevalence of metabolic syndrome (Mets) among individuals with Sarcopenic Obesity (SO), as well as to detect the potential association between the presence of SO and the higher risk of Mets.

Socioeconomics, metabolic syndrome, and osteopenia in postmenopausal women
The increased prevalence of metabolic syndrome and osteoporosis in postmenopausal women has prompted multiple research studies to understand why.

Metabolic syndrome associated with increased risk of blood clot recurrence
People with metabolic syndrome -- a set of conditions including obesity, impaired glucose metabolism, elevated levels of fats and cholesterol in the blood, and high blood pressure - are more likely to experience recurrent blood clots, according to a new study published today in Blood Advances.

Hops compounds help with metabolic syndrome while reducing microbiome diversity
Compounds from hops may combat metabolic syndrome by changing the gut microbiome and altering the metabolism of acids produced in the liver, new research suggests.

Metabolic syndrome: New use for an old drug
The discovery, described in a study by Cosbi and Cimec of the University of Trento published today in Nature Communications, confirms the effectiveness of repurposing, the new frontier of pharmacological research.

Three easy measures to predict metabolic syndrome in elderly
A new study found a surprisingly high rate of metabolic syndrome among individuals aged 60-100 years.

Nanovaccine boosts immunity in sufferers of metabolic syndrome
A new class of biomaterial developed by Cornell researchers for an infectious disease nanovaccine effectively boosted immunity in mice with metabolic disorders linked to gut bacteria - a population that shows resistance to traditional flu and polio vaccines.

Natural sugar defends against metabolic syndrome, in mice
New research, in mice, indicates that a natural sugar called trehalose blocks glucose from the liver and activates a gene that boosts insulin sensitivity, reducing the chance of developing diabetes.

Read More: Metabolic Syndrome News and Metabolic Syndrome Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.