Female lung transplant recipients at greater risk of acute lung injury

May 24, 2005

SAN DIEGO-Female lung transplant recipients are significantly more likely to suffer from a type of injury to the transplanted lung called primary graft dysfunction than male lung transplant patients, according to a study to be presented at the American Thoracic Society International Conference on May 24.

The study found that female lung transplant recipients who received a lung from either a male or female donor were almost 60% more likely to suffer from primary graft dysfunction, compared with male recipients who received their lung from a male donor.

"There are a number of possible reasons why women are at increased risk," said lead researcher Catherine Kuntz, M.D., Pulmonary Fellow at the Hospital of the University of Pennsylvania. "It may involve women's hormones or differences in their immune systems."

The study included data on all 7,482 adult lung transplants performed in the United States between 1994 and 2002. The researchers took into account factors such as the donor's age, race, cause of death, and the recipient's age, race and reason for lung transplant, as well as the size matching between the donor and recipient.

Overall, approximately 10% of transplant recipients suffered from primary graft dysfunction, which is an acute severe lung injury that occurs within the first 72 hours after the transplant and has a high mortality.

Once the lung is taken out of the donor, it is put on ice, and during this time, no blood flows through the organ. When the lung is transplanted into the recipient and all the blood vessels are reattached, injury to the lung may become apparent. Lung graft dysfunction is associated with a high death rate, prolonged hospital stay and other serious complications.

"We need further investigation into what it is about women that increases the risk," Dr. Kuntz said. "We need to look at factors such as whether the women have gone through menopause, and how many children they've had."

According to the United Network for Organ Sharing (UNOS) there are currently 3,688 Americans waiting for a lung transplant for diseases including cystic fibrosis, chronic obstructive pulmonary disease (COPD), primary pulmonary hypertension and pulmonary fibrosis.
-end-


American Thoracic Society

Related Blood Vessels Articles from Brightsurf:

Biofriendly protocells pump up blood vessels
In a new study published today in Nature Chemistry, Professor Stephen Mann and Dr Mei Li from Bristol's School of Chemistry, together with Associate Professor Jianbo Liu and colleagues at Hunan University and Central South University in China, prepared synthetic protocells coated in red blood cell fragments for use as nitric oxide generating bio-bots within blood vessels.

Specific and rapid expansion of blood vessels
Upon a heart infarct or stroke, rapid restoration of blood flow, and oxygen delivery to the hypo perfused regions is of eminent importance to prevent further damage to heart or brain.

Flexible and biodegradable electronic blood vessels
Researchers in China and Switzerland have developed electronic blood vessels that can be actively tuned to address subtle changes in the body after implantation.

Lumpy proteins stiffen blood vessels of the brain
Deposits of a protein called ''Medin'', which manifest in virtually all older adults, reduce the elasticity of blood vessels during aging and hence may be a risk factor for vascular dementia.

Cancer cells take over blood vessels to spread
In laboratory studies, Johns Hopkins Kimmel Cancer Center and Johns Hopkins University researchers observed a key step in how cancer cells may spread from a primary tumor to a distant site within the body, a process known as metastasis.

Novel function of platelets in tumor blood vessels found
Scientists at Uppsala University have discovered a hitherto unknown function of blood platelets in cancer.

Blood vessels can make you fat, and yet fit
IBS scientists have reported Angiopoietin-2 (Angpt2) as a key driver that inhibits the accumulation of potbellies by enabling the proper transport of fatty acid into general circulation in blood vessels, thus preventing insulin resistance.

Brothers in arms: The brain and its blood vessels
The brain and its surrounding blood vessels exist in a close relationship.

Feeling the pressure: How blood vessels sense their environment
Researchers from the University of Tsukuba discovered that Thbs1 is a key extracellular mediator of mechanotransduction upon mechanical stress.

Human textiles to repair blood vessels
As the leading cause of mortality worldwide, cardiovascular diseases claim over 17 million lives each year, according to World Health Organization estimates.

Read More: Blood Vessels News and Blood Vessels Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.