Alcohol exposure during adolescence leads to chronic stress vulnerability

May 24, 2016

BINGHAMTON, NY - Drinking during early to mid-adolescence can lead to vulnerability to chronic stress, according to new research from Binghamton University, State University of New York.

A research team led by Linda Spear, distinguished professor of psychology at Binghamton University, gave alcohol to rats every other day, starting from early to mid-adolescence. When the team looked at the same rats in adulthood, they found that adult males didn't show hormonal stress adaptation, making them more vulnerable to chronic stress.

"Stress hormones are released when you get anxious or are in a stressful circumstance," said Spear. "The classic stress hormone is cortisol in humans; it's corticosterone in rats. When you expose the animals to a stressor, the first time they show a large hormone stress response. However, this hormonal response normally adapts over time, such that less hormone is released following repeated exposure to a relatively mild stressor. And that's important, because cortisol or corticosterone helps you respond to an emergency. But it's bad to have elevated levels in the long term, because sustained elevations in these levels of these hormones have adverse effects on a lot of body systems. So cortisol is needed for emergencies, but you don't want it elevated all the time. And what we found is that following adolescent alcohol exposure, adults don't show that hormonal stress adaptation. They don't adapt to the chronic stressor, which suggests that they may be more vulnerable later to chronic stress."

Spear's work is a part of a national consortium, funded by the National Institute of Alcohol and Alcohol Abuse, that's examining, using animal models, the effects of alcohol exposure during adolescence.

"I think what these studies are showing is that there are long-lasting effects from adolescent alcohol exposure, and it is not innocuous. And these effects are most dramatic with exposures during mid- and early adolescence, which is the time when alcohol use is typically initiated in humans. So now we're trying to understand the neural mechanisms that underlie these effects, and ways to prevent or reverse consequences of adolescent alcohol exposure," said Spear.
-end-
The study, "Chronic intermittent ethanol exposure during adolescence: Effects on stress-induced social alterations and social drinking in adulthood," was published in Brain Research.

Binghamton University

Related Alcohol Articles from Brightsurf:

Alcohol use changed right after COVID-19 lockdown
One in four adults reported a change in alcohol use almost immediately after stay-at-home orders were issued: 14% reported drinking more alcohol and reported higher levels of stress and anxiety than those who did not drink and those whose use stayed the same.

Changes in hospitalizations for alcohol use disorder in US
Changes over nearly two decades in the rate of hospitalizations and in-hospital deaths from alcohol use disorder in the US were examined in this study.

Associations of alcohol consumption, alcohol-induced passing out with risk of dementia
The risk of future dementia associated with overall alcohol consumption and alcohol-induced loss of consciousness in a population of current drinkers was examined in this observational study with more than 131,000 adults.

New alcohol genes uncovered
Do you have what is known as problematic alcohol use?

Does estrogen influence alcohol use disorder?
A new study from researchers at the University of Illinois at Chicago shows that high estrogen levels may make alcohol more rewarding to female mice.

Sobering new data on drinking and driving: 15% of US alcohol-related motor vehicle fatalities involve alcohol under the legal limit
A new study in the American Journal of Preventive Medicine, published by Elsevier, found that motor vehicle crashes involving drivers with blood alcohol concentrations (BACs) below the legal limit of 0.08 percent accounted for 15% of alcohol-involved crash deaths in the United States.

Alcohol-induced deaths in US
National vital statistics data from 2000 to 2016 were used to examine how rates of alcohol-induced deaths (defined as those deaths due to alcohol consumption that could be avoided if alcohol weren't involved) have changed in the US and to compare the results by demographic groups including sex, race/ethnicity, age, socioeconomic status and geographic location.

Cuts in alcohol duty linked to 2000 more alcohol-related deaths in England
Government cuts to alcohol taxes have had dramatic consequences for public health, including nearly 2000 more alcohol-related deaths in England since 2012, according to new research from the University of Sheffield's School of Health and Related Research (ScHARR).

Integrated stepped alcohol treatment for people in HIV care improves both HIV & alcohol outcomes
Increasing the intensity of treatment for alcohol use disorder (AUD) over time improves alcohol-related outcomes among people with HIV, according to new clinical research supported by the National Institutes of Health.

The Lancet:Targets to reduce harmful alcohol use are likely to be missed as global alcohol intake increases
Increasing rates of alcohol use suggest that the world is not on track to achieve targets against harmful alcohol use, according to a study of 189 countries' alcohol intake between 1990-2017 and estimated intake up to 2030, published in The Lancet.

Read More: Alcohol News and Alcohol Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.