Nav: Home

1 in 4 patients develop heart failure within 4 years of first heart attack

May 24, 2016

Florence, Italy - 24 May 2016: One in four patients develop heart failure within four years of a first heart attack, according to a study in nearly 25 000 patients presented today at Heart Failure 2016 and the 3rd World Congress on Acute Heart Failure by Dr Johannes Gho, a cardiology resident at the University Medical Center Utrecht, in Utrecht, the Netherlands.1 Risk factors included older age, greater socioeconomic deprivation, and comorbidities such as diabetes.

"Heart failure is a major medical problem with a high chance of hospitalisation and death," said Dr Gho. "Patients with ischaemic heart disease are at the highest risk. This includes those who have had a myocardial infarction, also called heart attack."

He continued: "Research studying incidence of heart failure following myocardial infarction is limited and mainly stems from the thrombolytic era, when drugs were used to dissolve blood clots. Today the preferred treatment for acute myocardial infarction is percutaneous coronary intervention (PCI) where a stent is used to open the blocked artery."

The current study used prospectively collected electronic health records to investigate the contemporary incidence and risk factors for heart failure after a first myocardial infarction. "Finding which heart attack patients are most likely to get heart failure would help us target preventive therapies," said Dr Gho.

The study used data from the UK based CALIBER (CArdiovascular research using LInked Bespoke studies and Electronic health Records) programme. Primary care records were linked to hospital admissions and national registries on myocardial infarction and mortality.

The researchers identified 24 745 patients aged 18 years or older who experienced a first myocardial infarction between 1 January 1998 and 25 March 2010 and had no prior history of heart failure. Patients were followed up for a median of 3.7 years for the first recorded heart failure diagnosis in any of the CALIBER sources.

During follow-up, 6005 (24.3%) patients developed heart failure. Dr Gho said: "Around one in four patients developed heart failure within four years of a first myocardial infarction in the current era. This was relatively stable over time possibly due to two competing trends. On the one hand, PCI has improved treatment for myocardial infarction so the risk of heart failure would be expected to decrease. On the other hand, because treatment has improved, more patients are alive after a heart attack to subsequently get heart failure."

A number of factors were associated with an increased risk of developing heart failure after a first myocardial infarction. Every ten year rise in age was associated with a 45% increased risk. Greater socioeconomic deprivation (5th versus 1st quintile) was associated with a 27% increased risk.

The following conditions were associated with a higher risk of developing heart failure after a first myocardial infarction: diabetes (44% increased risk), atrial fibrillation (63% increased risk), peripheral arterial disease (38% increased risk), chronic obstructive pulmonary disease (28% increased risk), ST elevation myocardial infarction at presentation (21% increased risk), and hypertension (16% increased risk).

Dr Gho said: "Previous research looking at all cause heart failure, not only after myocardial infarction, has found similar risk factors. Our large cohort study confirms that these are also risky conditions for heart attack patients in the current era."

He concluded: "Identifying these prognostic factors in heart attack patients could help us predict their risk of developing heart failure and allow us to give treatments to reduce that risk."
-end-


European Society of Cardiology

Related Diabetes Articles:

Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).
Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.
People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.
Diabetes, but not diabetes drug, linked to poor pregnancy outcomes
New research indicates that pregnant women with pre-gestational diabetes who take metformin are at a higher risk for adverse pregnancy outcomes -- such as major birth defects and pregnancy loss -- than the general population, but their increased risk is not due to metformin but diabetes.
New oral diabetes drug shows promise in phase 3 trial for patients with type 1 diabetes
A University of Colorado Anschutz Medical Campus study finds sotagliflozin helps control glucose and reduces the need for insulin in patients with type 1 diabetes.
More Diabetes News and Diabetes Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Rethinking Anger
Anger is universal and complex: it can be quiet, festering, justified, vengeful, and destructive. This hour, TED speakers explore the many sides of anger, why we need it, and who's allowed to feel it. Guests include psychologists Ryan Martin and Russell Kolts, writer Soraya Chemaly, former talk radio host Lisa Fritsch, and business professor Dan Moshavi.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...