Nav: Home

Mechanisms of neuronal cell death in AGE-exposed retinas -- research and literature review

May 25, 2017

Gradual accumulation of glycated proteins, lipids and nucleic acid is a common process in normal aging, however rise in blood glucose levels, an increase of oxidative stress over time triggering further protein modification and resulting in impairment of defense mechanisms. AGEs accumulation in various tissues under diabetic conditions plays an important role in the development of neuronal and vascular complications such as diabetic retinopathy. Glycation plays a significant role in the pathogenesis of retinal diabetic neuropathy by triggering different mechanisms resulting in neuronal dysfunction.The death of retinal ganglion cells (RGCs) and their axons is the common pathological change in AGE-exposed retina. Identifying the mechanisms of the onset and progression of RGC death and axonal degeneration in patients with diseases associated with AGEs accumulation including diabetic retinopathy are represented in this review e.g. results of laboratory studies with the suggestion that AGEs play an important role in the pathogenesis of diabetic retinal neuropathy triggering different mechanisms that result in neuronal dysfunction.

Additionally new therapeutic approaches, the regenerative effect of different neurotrophic factors such as neurotrophin-4, hepatocyte growth factor, glial cell line-derived neurotrophic factor, and Tauroursodeoxycholic acid on RGCs are represented in this review.
-end-
For more information about the article, please visit http://www.eurekaselect.com/node/142324/article/mechanisms-of-neuronal-cell-death-in-age-exposed-retinas-research-and-literature-review

Reference:

BikBova G. (2017). Mechanisms of Neuronal Cell Death in AGE-exposed Retinas - Research and Literature Review, Curr Diabetes Review., DOI: 10.2174/1573399812666160519111333

Bentham Science Publishers

Related Diabetic Retinopathy Articles:

Scientists identify a possible new treatment for diabetic retinopathy
About 1 in 3 diabetic patients develops diabetic retinopathy (DR), which can impair vision and lead to blindness.
Asthma medication inhibits changes in diabetic retinopathy in type 1 diabetes mouse
A new study found the asthma medication montelukast (brand name Singulair) can inhibit early changes in diabetic retinopathy, the eye disease which develops due to diabetes, in a mouse model of type 1 diabetes.
Earlier detection of diabetic retinopathy with smartphone AI
Equipping a smartphone to capture retinal images and utilizing artificial intelligence to interpret them may help overcome barriers to ophthalmic screening for people with diabetes, new Kellogg Eye Center research shows.
Diabetic drug shown to reduce the risk of heart disease in non-diabetic patients
Metformin could reverse the harmful thickening of heart muscle that leads to cardiovascular disease, according to researchers at the University of Dundee.
CHOP researchers develop easy-to-implement predictive screening tool for retinopathy
A multi-hospital collaboration led by researchers at Children's Hospital of Philadelphia (CHOP) has found a simple method of determining which premature infants should be screened for retinopathy of prematurity (ROP).
More Diabetic Retinopathy News and Diabetic Retinopathy Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Erasing The Stigma
Many of us either cope with mental illness or know someone who does. But we still have a hard time talking about it. This hour, TED speakers explore ways to push past — and even erase — the stigma. Guests include musician and comedian Jordan Raskopoulos, neuroscientist and psychiatrist Thomas Insel, psychiatrist Dixon Chibanda, anxiety and depression researcher Olivia Remes, and entrepreneur Sangu Delle.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...