Fatal cases of COVID-19 deepen our understanding of the disease's progression

May 25, 2020

If we understand the risk factors that lead to mortality among COVID-19 patients, we can prevent deaths caused by the disease. That was the impetus behind the recent paper published in Frontiers in Medicine, in which researchers in Wuhan, China studied how the illness progressed among fatal cases.

"A better understanding of the disease progression, especially for the severe or critically ill cases, is essential to the control and treatment of this epidemic," says lead author Dr. Liang Shao, of Wuhan University's Zhongnan Hospital, where the study took place.

Shao says that while the overall mortality rate of COVID-19 is estimated to be about 2%, "over 50% of critically ill COVID-19 patients in Wuhan finally died due to multiple organ dysfunction and severe complications."

The study examined 155 patients diagnosed with COVID-19 at Zhongnan Hospital, paying particular attention to the 18 who did not survive. Most of the non-survivors were men over the age of 65 with underlying conditions, and many became co-infected with other respiratory viruses, bacteria, and mycoplasma over the course of the illness. Of the 18 patients studied, 17 developed acute respiratory distress syndrome (ARDS) by the time of their death, 10 had acute cardiac injury, and 7 had acute kidney injury.

Patients also had marked decreases in T cells, a sign of a weakened immune response, as well as decreases in plasma protein and albumin. The authors emphasized that early intervention was crucial. In fatal cases, the median hospital stay was just 13.5 days, meaning that patients died within a couple weeks of being admitted.

Shao says these findings "provide important clues for the frontline physicians during the fighting with COVID-19." For example, timely nutrition support is necessary to treat decreased plasma proteins and albumin. Antibiotics should also be used to treat bacterial co-infection. The authors emphasized that early interventions should be taken when possible. They also noted that survival rates may have been affected by the fact that some patients and relatives declined treatments, such as mechanical ventilation and continuous renal replacement therapy (a form of dialysis), due to the patient's old age.

This study was limited by its small sample size (18 patients), along with the fact that the data analyzed came from a single site. The authors recommend that further studies should study a larger number of patients at multiple sites in order to accurately understand how COVID-19 manifests and advances.
Notes to Editors

Please link to the original research article in your reporting: https://www.frontiersin.org/articles/10.3389/fmed.2020.00246/full

Corresponding author: Prof. Fuling Zhou

Email: zhoufuling@163.com

Corresponding Author's Institution: Zhongnan Hospital of Wuhan University

Frontiers is an award-winning Open Science platform and leading Open Access scholarly publisher. Our mission is to make research results openly available to the world, thereby accelerating scientific and technological innovation, societal progress and economic growth. We empower scientists with innovative Open Science solutions that radically improve how science is published, evaluated and disseminated to researchers, innovators and the public. Access to research results and data is open, free and customized through Internet Technology, thereby enabling rapid solutions to the critical challenges we face as humanity. For more information, visit http://www.frontiersin.org and follow @Frontiersin on Twitter.


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