Electronic cigarettes trigger an inflammatory response that may set the stage for gum disease

May 27, 2020

Electronic Cigarettes Trigger an Inflammatory Response That May Set the Stage for Gum Disease

The oral microbiomes of 25 otherwise healthy participants who use e-cigarettes daily closely match those seen in patients with gum disease, a new study shows. The results suggest that e-cigarettes trigger a proinflammatory response, coating commensal bacteria in the mouth with a layer of slime that makes them unrecognizable to the body and prevents the sequential colonization of other bacteria that form a healthy community. Sukirth Ganesan and colleagues conclude that the glycerol/glycol vehicle in e-cigarettes appears to drive these changes. E-cigarettes have grown wildly popular among Americans, with six percent of the country's population - including 2.5 million high schoolers - puffing on the products nine years after their introduction to the United States. But while these e-cigarettes contain potentially toxic substances, including volatile organic compounds and metals, much remains unknown their long-term effects on human health. To gain insight into how e-cigarettes affect the oral microbiome, Ganesan et al. recruited 123 otherwise healthy individuals, including 25 smokers, 25 nonsmokers, 20 e-cigarette users, 25 former smokers currently using e-cigarettes, and 28 smokers who also use e-cigarettes. They created a catalog of bacterial genes in the microbial communities of e-cigarette users based on plaque samples collected from their teeth, finding that variations arose based on the duration of e-cigarette use, but were not tied to variations in the concentration of nicotine or the type of flavoring. The researchers also observed that while both smoking and e-cigarette use cause inflammation, they do so through different molecular pathways. "I am hoping this research will drive some level of policymaking about the harm we are seeing," said Purnima Kumar, a coauthor of the study, in an interview, challenging the popular perception that e-cigarettes provide a safer alternative to smoking. "If we can see changes in people who are otherwise healthy and have nothing wrong with them, then we should start seriously considering why would you put their lives and their wellbeing at risk."
-end-


American Association for the Advancement of Science

Related Bacteria Articles from Brightsurf:

Siblings can also differ from one another in bacteria
A research team from the University of Tübingen and the German Center for Infection Research (DZIF) is investigating how pathogens influence the immune response of their host with genetic variation.

How bacteria fertilize soya
Soya and clover have their very own fertiliser factories in their roots, where bacteria manufacture ammonium, which is crucial for plant growth.

Bacteria might help other bacteria to tolerate antibiotics better
A new paper by the Dynamical Systems Biology lab at UPF shows that the response by bacteria to antibiotics may depend on other species of bacteria they live with, in such a way that some bacteria may make others more tolerant to antibiotics.

Two-faced bacteria
The gut microbiome, which is a collection of numerous beneficial bacteria species, is key to our overall well-being and good health.

Microcensus in bacteria
Bacillus subtilis can determine proportions of different groups within a mixed population.

Right beneath the skin we all have the same bacteria
In the dermis skin layer, the same bacteria are found across age and gender.

Bacteria must be 'stressed out' to divide
Bacterial cell division is controlled by both enzymatic activity and mechanical forces, which work together to control its timing and location, a new study from EPFL finds.

How bees live with bacteria
More than 90 percent of all bee species are not organized in colonies, but fight their way through life alone.

The bacteria building your baby
Australian researchers have laid to rest a longstanding controversy: is the womb sterile?

Hopping bacteria
Scientists have long known that key models of bacterial movement in real-world conditions are flawed.

Read More: Bacteria News and Bacteria Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.