New hope for severe heart disease patients

May 29, 2007

Funded by the MBF Foundation, the second phase of the project will test whether using the G-SCF hormone to stimulate the release of blood vessel-forming stem cells can alleviate the condition, improve heart function and increase quality of life for people with severe heart disease.

Executive Director of the Victor Chang Cardiac Research Institute, Professor Bob Graham, said evidence from the first phase of the study into the safety of the G-SCF treatment gave hope to the patients taking part. Many of these patients currently rely on numerous medications to relieve the pain caused by the lack of blood supply to the heart.

"The 20 patients trialling the innovative treatment responded extremely positively, with most experiencing a reduction in angina and finding that they were able to reduce their intake of pain relief with marked improvements in some patients," Professor Graham said.

"This is an incredible result, especially when you consider that many of these patients had already undergone multiple surgeries to try and correct the defects causing their heart to malfunction and were on the maximum doses of conventional medicines, yet still experienced chest pain from even the slightest exertion.

"However," he cautioned, "this was a safety trial and therefore was not placebo controlled, so we can't be absolutely sure yet if the improvements are entirely due to the G-CSF, hence the need for the next study.

The new phase of the trial involving 40 patients will combine physiotherapist-monitored exercise with Magnetic Resonance Imaging (MRI) scans to analyse how effectively the heart is operating. Half of the study participants will then be given low doses of G-SCF with the remainder receiving a saline placebo as a control. After 12weeks, heart function will again be checked using an MRI and the treatments of the two groups will be swapped with a final MRI scan three months later.

MBF Chief Medical Officer, Dr Christine Bennett, said the MBF Foundation is supporting this innovative study because of its potential to revolutionise the way in which severe heart disease is treated.

"If the study proves successful, an effective and easy to administer treatment regime involving simple injections under the skin, similar to insulin injections for diabetics, could be ready within three years," Dr Bennett said. "This outcome would be a great development for people with severe heart disease offering the exciting prospect of relief from constant pain in the foreseeable future."
The MBF Foundation is a charitable institution set up by MBF to support and manage important health initiatives for the community using a portion of MBF Group's investment income each year. Projects undertaken encompass three key areas - wellness and obesity, supporting healthy ageing and keeping healthcare affordable.

Research Australia

Related Magnetic Resonance Imaging Articles from Brightsurf:

Topology gets magnetic: The new wave of topological magnetic materials
The electronic structure of nonmagnetic crystals can be classified by complete theories of band topology, reminiscent of a 'topological periodic table.' However, such a classification for magnetic materials has so far been elusive, and hence very few magnetic topological materials have been discovered to date.

KIST develops ambient vibration energy harvester with automatic resonance tuning mechanism
Korean researchers have developed an energy harvester that can generate electric power from ambient vibrations with diverse frequencies through a novel automatic resonance tuning mechanism.

Cardiovascular magnetic resonance imaging findings in competitive college athletes after COVID-19
This study investigated the use of cardiac magnetic resonance imaging in competitive college athletes who recovered from COVID-19 to detect myocardial inflammation that would identify high-risk athletes for return to competitive play.

Using magnetic resonance elastography to detect epilepsy
A new study from the Beckman Institute used magnetic resonance elastography to compare the hippocampal stiffness in healthy individuals with those who have epilepsy.

Spintronics: Researchers show how to make non-magnetic materials magnetic
A complex process can modify non-magnetic oxide materials in such a way to make them magnetic.

Manipulating non-magnetic atoms in a chromium halide enables tuning of magnetic properties
The magnetic properties of a chromium halide can be tuned by manipulating the non-magnetic atoms in the material, a team, led by Boston College researchers, reports in the most recent edition of ScienceAdvances.

Imaging magnetic instabilities using laser accelerated protons
An international team of researchers is the first to experimentally demonstrate the 'Weibel' instabilities predicted by theory about 50 years ago, in the prestigious journal Nature Physics.

Single-spin electron paramagnetic resonance spectrum with kilohertz spectral resolution
A high-resolution paramagnetic resonance detection method based on the diamond nitrogen-vacancy (NV) color center quantum sensor was proposed and experimentally implemented by academician DU Jiangfeng from USTC.

Convenient location of a near-threshold proton-emitting resonance in 11B
Polish scientists working in Poland, France and USA explained the mysterious β-delayed proton decay of the neutron halo ground state of 11Be.

Detection of very high frequency magnetic resonance could revolutionize electronics
A team of scientists led by a physicist at the University of California, Riverside, has discovered an electrical detection method for terahertz electromagnetic waves, which are extremely difficult to detect.

Read More: Magnetic Resonance Imaging News and Magnetic Resonance Imaging Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to