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An ecological risk research agenda for synthetic biology

May 29, 2014

Washington -- Environmental scientists and synthetic biologists have for the first time developed a set of key research areas to study the potential ecological impacts of synthetic biology, a field that could push beyond incremental changes to create organisms that transcend common evolutionary pathways.

The Synthetic Biology Project at the Wilson Center and the Program on Emerging Technologies at the Massachusetts Institute of Technology convened the interdisciplinary group of scientists and are releasing the report, Creating a Research Agenda for the Ecological Implications of Synthetic Biology. The work was funded by a grant from the National Science Foundation (NSF).

"We hope this report raises awareness about the lack of research into these ecological issues," says Dr. James Collins, Ullman Professor of Natural History and the Environment at Arizona State University and former Director of the Population Biology and Physiological Ecology Program and Assistant Director of Biological Sciences at NSF. "We involved experts in the ecological research and synthetic biology communities to help identify priority research areas - and we believe the report can be a roadmap to guide the necessary work. The rapid pace of research and commercialization in the field of synthetic biology makes it important to begin this work now."

The report prioritizes key research areas for government agencies, academia and industry to fund. Research areas include species for comparative research; phenotypic characterization; fitness, genome stability and lateral gene transfer; control of organismal traits; monitoring and surveillance; modeling and standardization of methods and data.

In developing the report, various applications were used to stimulate discussion among synthetic biologists, ecologists, environmental scientists and social scientists, as well as representatives from government, the private sector, academia, environmental organizations and think tanks. Applications considered in the process included bio-mining; nitrogen fixation by engineered crops; gene drive propagation in populations of invasive species; and engineered seeds and plants destined for distribution to the public.

The report says it is necessary to establish and sustain interdisciplinary research groups in order to conduct the research. Long-term support is also needed to address complex questions about how synthetic biology could impact the environment and overcome communication barriers across disciplines, the report says.
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The report can be downloaded from the Synthetic Biology Project website: http://www.synbioproject.org/library/publications/archive/6685/

About the Synthetic Biology Project

The Synthetic Biology Project is an initiative of the Woodrow Wilson International Center for Scholars supported by a grant from the Alfred P. Sloan Foundation. The Project aims to foster informed public and policy discourse concerning the advancement of synthetic biology. For more information, visit: http://www.synbioproject.org

About the MIT Program on Emerging Technologies

The Center for International Studies (CIS) aims to support and promote international research and education at MIT. The CIS Program on Emerging Technologies (PoET) seeks to improve responses to implications of emerging technologies. PoET was created with support of an NSF IGERT. Research has included retrospective studies on past emerging technologies led by Merritt Roe Smith, Larry McCray and Daniel Hastings, as well as prospective studies on next-generation internet (led by David D. Clark) and synthetic biology (led by Kenneth A. Oye). For more information, visit: http://web.mit.edu/cis/

About The Wilson Center

The Wilson Center provides a strictly nonpartisan space for the worlds of policymaking and scholarship to interact. By conducting relevant and timely research and promoting dialogue from all perspectives, it works to address the critical current and emerging challenges confronting the United States and the world. For more information, visit: http://www.wilsoncenter.org

Woodrow Wilson International Center for Scholars/Science and Technology Innovation Program

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