Nav: Home

Atherosclerosis: Stopped on time

May 31, 2018

The internal clock controls all vital functions in the body. Body temperature as well as blood pressure or the release of certain enzymes are subject to oscillations throughout the day, the so-called circadian rhythm. For the first time, a team around Professor Oliver Söhnlein has now shown the influence of circadian rhythms on atherosclerosis - a vascular disease that ultimately can lead to heart attacks and strokes. His study, recently published in the scientific journal Cell Metabolism, could be crucial for the improvement of therapeutic approaches.

Oliver Söhnlein researches molecular mechanisms underlying atherosclerosis at the Institute for Cardiovascular Prevention. During this disease, lipid deposits can form on the inner vascular wall of large arteries. Cells of the immune system travel from the blood to the damaged location and attract more and more cells via signaling substances until the immune reaction finally derails. Atherosclerotic inflammation develops over years; however, the recruitment of cells is subject to circadian rhythms as Söhnlein has proven in mouse models of atherosclerosis. "At certain times of the day, three times as many leukocytes travel to the center of arterial inflammation as it is the case for other times," says Söhnlein. This rhythmic migration pattern is about 12 hours phase shifted with the recruitment pattern observed in the microcirculation in small veins.

Precisely this shift between the two vascular systems is interesting from a therapeutic aspect. "The recruitment of white blood cells in the micro-circulation is important for acute infections such as for example a lung or bladder infection," explains Oliver Söhnlein. Ideally, the recruitment of immune cells is to be stopped for the atherosclerotic inflammation but not in the micro-circulation.

The researchers of LMU achieved just that with their work in an early stage of atherosclerosis: On the one hand, they identified the molecular mechanism how rhythmic arterial leukocyte migration is controlled. On the other hand, timed inhibition of this pathway centered on the chemokine CCL2, they were able to stop the recruitment only into atherosclerotic areas but did not affect microvascular leukocyte migration. "Our study shows how circadian patterns can be used for timed therapeutic intervention possibly with lower side effects and higher efficacy," says Söhnlein.

In further studies the researchers want to examine to which extent circadian rhythms contribute to destabilization for advanced atherosclerosis. In addition, they want to focus on studying the circadian regulation of processes in the atherosclerotic deposits themselves, for example the question whether cell death is controlled in a circadian fashion.
-end-


Ludwig-Maximilians-Universität München

Related Atherosclerosis Articles:

Atherosclerosis progresses rapidly in healthy people from the age of 40
A CNIC study published in JACC demonstrates that atheroma plaques extend rapidly in the arteries of asymptomatic individuals aged between 40 and 50 years participating in the PESA-CNIC-Santander study.
Discovery may illuminate a missing link between atherosclerosis and aging
Using a preclinical model of atherosclerosis, Feinberg and colleagues have uncovered a long, noncoding RNA (lncRNA) that may point the way toward new therapies for atherosclerosis and shed light on why the likelihood of the disease increases with age.
Scaling up a nanoimmunotherapy for atherosclerosis through preclinical testing
By integrating translational imaging techniques with improvements to production methods, Tina Binderup and colleagues have scaled up a promising nanoimmunotherapy for atherosclerosis in mice, rabbits and pigs -- surmounting a major obstacle in nanomedicine.
Bladder drug linked to atherosclerosis in mice
A drug used in the treatment of overactive bladder can accelerate atheroclerosis in mice, researchers at Karolinska Institutet in Sweden report in a study published in the Proceedings of the National Academy of Sciences (PNAS).
Atherosclerosis: Induced cell death destabilizes plaques
Many chronic disorders arise from misdirected immune responses. A Ludwig-Maximilians-Universitaet (LMU) in Munich team led by Oliver Söhnlein now shows that neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death and that a tailored peptide inhibits the process.
A new therapeutic target for blocking early atherosclerosis in progeria
Researchers at the Centro Nacional de Investigaciones Cardiovasculares and the Universidad de Oviedo have discovered a new molecular mechanism involved in the premature development of atherosclerosis in mice with Hutchinson-Gilford progeria syndrome.
Protective mechanism against atherosclerosis discovered
Immune cells promoting inflammation play a crucial role in the development of atherosclerosis.
Atherosclerosis: Stopped on time
For the first time, LMU researchers are pointing out the influence of the internal clock on atherosclerosis.
New actors identified in atherosclerosis
Stroke and heart attack are the leading cause of death in the Western world.
Running multiple marathons does not increase risk of atherosclerosis
Running multiple marathons does not increase the risk of atherosclerosis, according to research published today in the European Journal of Preventive Cardiology.
More Atherosclerosis News and Atherosclerosis Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Climate Mindset
In the past few months, human beings have come together to fight a global threat. This hour, TED speakers explore how our response can be the catalyst to fight another global crisis: climate change. Guests include political strategist Tom Rivett-Carnac, diplomat Christiana Figueres, climate justice activist Xiye Bastida, and writer, illustrator, and artist Oliver Jeffers.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Speedy Beet
There are few musical moments more well-worn than the first four notes of Beethoven's Fifth Symphony. But in this short, we find out that Beethoven might have made a last-ditch effort to keep his music from ever feeling familiar, to keep pushing his listeners to a kind of psychological limit. Big thanks to our Brooklyn Philharmonic musicians: Deborah Buck and Suzy Perelman on violin, Arash Amini on cello, and Ah Ling Neu on viola. And check out The First Four Notes, Matthew Guerrieri's book on Beethoven's Fifth. Support Radiolab today at Radiolab.org/donate.