Concern over 'aggressive' cholesterol recommendations

June 01, 2006

New US recommendations for lowering cholesterol levels would increase the risk of harmful side effects with no overall reduction in deaths, warn experts in this week's BMJ.

The American National Cholesterol Education Program has said that people at high risk of heart disease should be treated more aggressively.

By aggressively, it means that LDL-cholesterol concentrations should be lowered to less than 1.81 millimoles per litre of blood (mmol/l) in high-risk individuals. Current guidelines generally recommend 2.56 mmol/l as a healthy reading.

To achieve this new goal, most of the Western world's adult population would be on statins, and doses would have to be more than eight times higher than currently used, say the authors. This would increase both the number and seriousness of side effects.

But clinical trials suggest that higher doses of statins do not lower overall mortality and side effects are generally under-reported.

The authors conclude that any reduction in non-fatal events may be outweighed by more numerous and more severe adverse effects.
-end-


BMJ

Related Statins Articles from Brightsurf:

Being in treatment with statins reduces COVID-19 mortality by 22% to 25%
A research by the Universitat Rovira i Virgili (URV) and Pere Virgili Institut (IISPV) led by LluĂ­s Masana has found that people who are being treated with statins have a 22% to 25% lower risk of dying from COVID-19.

Twitter data research reveals more about what patients think about statins
More than one in seven people taking statins -- prescribed to lower cholesterol levels -- believed that meant they could still eat unhealthy foods, a new study shows.

Statins starve cancer cells to death
More than 35 million Americans take statin drugs daily to lower their blood cholesterol levels.

Statins linked to higher diabetes risk
Individuals who take cholesterol-lowering statins may be at higher risk for developing high blood sugar levels, insulin resistance, and eventually type 2 diabetes, according to an analysis published in the British Journal of Clinical Pharmacology.

Statins could protect against motor neurone disease
High cholesterol has been found to be a possible risk factor for the development of motor neurone disease (MND), according to a large study of genetic data led in the UK by Queen Mary University of London, in collaboration with the National Institutes of Health in the USA.

Statins are more effective for those who follow the Mediterranean diet
For those who have already had a heart attack or a stroke, the combination of statins and Mediterranean Diet appears to be the most effective choice to reduce the risk of mortality, especially from cardiovascular causes.

Statins have low risk of side effects
Cholesterol-lowering statin drugs are associated with a low risk of side effects.

Statins overprescribed for primary prevention
Taking cholesterol-lowering drugs, or statins, as a preventive measure can reduce the risk of cardiovascular disease.

Many older adults do not take prescribed statins properly
In a British Journal of Clinical Pharmacology study of older adults prescribed statins, first-year nonadherence and discontinuation rates were high.

Statins show little promise for conditions other than heart disease
Medicines commonly prescribed to reduce people's risk of heart attack may have limited use for treating other diseases, research suggests.

Read More: Statins News and Statins Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.