Nav: Home

'Multiomics' and the newborn mouse heart

June 01, 2018

During the first days of life, the heart of a newborn mouse adapts to entirely new physiological conditions, larger volume loads and an increased energy demand. As a result, fundamental changes occur in the heart. Studies have shown that the heart of neonate mouse retains its ability to effectively repair tissue damage. This ability of the cardiac muscle to regenerate, however, gradually disappears during the first week of life.

One major problem in the treatment of heart disease is the inability of adult myocardial cells to regenerate. Thus, tissue damaged by, for example, myocardial infarction is not revived. New approaches for developing novel treatments are being sought to help patients regain heart function after myocardial infarction.

A research collaboration at Meilahti campus investigates the molecular mechanisms underlying myocardial regenerative ability. Research groups from the Medical Faculty at the University of Helsinki, the Institute of Molecular Medicine Finland (FIMM) and the Minerva Foundation Institute for Medical Research have recently published an analysis that combined three different systems-level methods on mechanisms associated with the loss of regenerative ability of the heart soon after birth.

The researchers used a large scale analytical platforms approach combining RNA sequencing, quantitative proteomics and metabolomics as well as bioinformatics to characterize the events initiated in the hearts of newborn mice during the first week after birth.

"We used a combination of different systems-level techniques and utilized the tools of transcriptomics, proteomics, metabolomics and bioinformatics. Co-operating with the top experts from different groups at the Meilahti campus, we were able to get a very comprehensive view of how the heart's metabolism is re-programmed within the first postnatal week", says Docent Esko Kankuri.

"Utilizing a 'multiomics' approach, we identified several cellular message pathways and processes that affect the re-programming of heart metabolism after birth. We discovered core molecular level events behind the regenerative capacity of the heart. Through our research, 1 937 proteins, 612 metabolites and 2 586 gene loci were associated with these processes", Kankuri adds.

Fructose-induced glycolysis was a key factor for myocardial regenerative ability, an activity associated with an increased proliferation of cardiac muscle cells during the first days after birth.

-These results also help us to understand the mechanisms of the human heart disease and what molecular factors affect myocardial regeneration. Understanding these mechanisms can open up possibilities for developing new types of treatments, says Docent Maciej Lalowski.
-end-
The study, funded by the Academy of Finland, was published in Frontiers in Physiology.

University of Helsinki

Related Heart Disease Articles:

Where you live could determine risk of heart attack, stroke or dying of heart disease
People living in parts of Ontario with better access to preventive health care had lower rates of cardiac events compared to residents of regions with less access, found a new study published in CMAJ (Canadian Medical Association Journal).
Older adults with heart disease can become more independent and heart healthy with physical activity
Improving physical function among older adults with heart disease helps heart health and even the oldest have a better quality of life and greater independence.
Dietary factors associated with substantial proportion of deaths from heart disease, stroke, and disease
Nearly half of all deaths due to heart disease, stroke, and type 2 diabetes in the US in 2012 were associated with suboptimal consumption of certain dietary factors, according to a study appearing in the March 7 issue of JAMA.
Certain heart fat associated with higher risk of heart disease in postmenopausal women
For the first time, researchers have pinpointed a type of heart fat, linked it to a risk factor for heart disease and shown that menopausal status and estrogen levels are critical modifying factors of its associated risk in women.
Maternal chronic disease linked to higher rates of congenital heart disease in babies
Pregnant women with congenital heart defects or type 2 diabetes have a higher risk of giving birth to babies with severe congenital heart disease and should be monitored closely in the prenatal period, according to a study published in CMAJ.
Novel heart valve replacement offers hope for thousands with rheumatic heart disease
A novel heart valve replacement method is revealed today that offers hope for the thousands of patients with rheumatic heart disease who need the procedure each year.
Younger heart attack survivors may face premature heart disease death
For patients age 50 and younger, the risk of premature death after a heart attack has dropped significantly, but their risk is still almost twice as high when compared to the general population, largely due to heart disease and other smoking-related diseases The risk of heart attack can be greatly reduced by quitting smoking, exercising and following a healthy diet.
Citrus fruits could help prevent obesity-related heart disease, liver disease, diabetes
Oranges and other citrus fruits are good for you -- they contain plenty of vitamins and substances, such as antioxidants, that can help keep you healthy.
Gallstone disease may increase heart disease risk
A history of gallstone disease was linked to a 23 percent increased risk of developing coronary heart disease.
Americans are getting heart-healthier: Coronary heart disease decreasing in the US
Coronary heart disease is one of the leading causes of death in the United States.

Related Heart Disease Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Bias And Perception
How does bias distort our thinking, our listening, our beliefs... and even our search results? How can we fight it? This hour, TED speakers explore ideas about the unconscious biases that shape us. Guests include writer and broadcaster Yassmin Abdel-Magied, climatologist J. Marshall Shepherd, journalist Andreas Ekström, and experimental psychologist Tony Salvador.
Now Playing: Science for the People

#513 Dinosaur Tails
This week: dinosaurs! We're discussing dinosaur tails, bipedalism, paleontology public outreach, dinosaur MOOCs, and other neat dinosaur related things with Dr. Scott Persons from the University of Alberta, who is also the author of the book "Dinosaurs of the Alberta Badlands".