Nav: Home

'Cannibalism' is a double-whammy for cell health

June 04, 2019

Certain Inflammatory and infectious diseases, such as hardening arteries and tuberculosis, are caused by the build-up inside immune cells of harmful substances, such as cholesterol and bacteria. A study published today by University of Sydney researcher Hugh Ford has shown that these concentrations occur in part by virtue of cell cannibalism.

Published in Proceedings B of the Royal Society, Mr Ford's research shows that substances that transfer via cannibalism will concentrate inside the population via a coalescence process, where particles continually cluster into larger aggregates.

"Cell cannibalism has been an underappreciated dynamic in the development of inflammatory diseases," he said.

Mr Ford is undertaking his PhD in applied mathematics at the University of Sydney and says his model, while applied in this instance to accumulation of cells, has broader implications.

"Our mathematical model shows that cannibalism has similar detrimental consequences in cells and in animals," Mr Ford said. "As with environmental ecosystems, cannibalism can transfer harmful substances between individual cells - or animals - and perpetuate disease transmission."

Mr Ford, working with colleagues at the University of Oxford, experimentally checked his model using mice bone-marrow derived macrophages (white blood cells) and how they form 'foam cells', which are the basis of arterial plaque in atherosclerosis, or hardening of arteries.

His supervisor is Professor Mary Myerscough from the School of Mathematics and Statistics, working in association with Professor Helen Byrne at the Mathematical Institute of Oxford. Professor Myerscough said: "Hugh's research has shown that the cannibalistic cells set up a 'double-whammy' for the build-up of harmful materials in the body.

"In the case of atherosclerosis, white blood cells that come to clear up cholesterol then die, leaving the LDL cholesterol in place, while adding their own cellular cholesterol."

Professor Myerscough said this leads to more white blood cells being sent in to clean up the mess, which in turn die, leading to an exponential build-up.

The problem escalates when normal processes that stimulate white blood cells to leave the tissue slow down or fail. Normally, these white blood cells, or macrophages, transport the dead materials into the lymphatic system. When this process breaks down, Mr Ford has developed a model that shows cell cannibalism contributes to the concentration of harmful materials in a cascading effect.

Professor Myerscough said that Mr Ford's study quantitatively considers cell emigration and brings this process into sharp focus.

Mr Ford conducted his research at the University of Oxford Mathematical Institute and the Sir William Dunn School of Pathology.

Principal Investigator Professor David Greaves from the Dunn School of Pathology at Oxford said: "Hugh's mathematical modelling allowed us to do a set of biology experiments that shed new light on the processes that drive diseases. Armed with these new insights we are keen to look for new drugs that enhance tissue protection by changing cell behaviour."

Mr Ford said the paper contributes to a growing body of evidence that casts cannibalistic cell removal as a double-edged sword.

"While on the one hand this process is crucial for tissue stability and the resolution of inflammation, it also perpetuates subcellular accumulation of harmful substances that can then contribute to the development of diseases, such as heart disease and tuberculosis," Mr Ford said.
Media enquiries

Marcus Strom | | +61 423 982 485
Lead author: Hugh Ford | | +44 7435 118 540
Co-author: Professor Mary Myerscough | | +61 2 9351 3724

Funding statement

This work was funded by the Australian Research Council Discovery Program grant DP160104685 and British Heart Foundation program grant RG/15/10/31485.

University of Sydney

Related Cholesterol Articles:

Rethinking how cholesterol is integrated into cells
Cholesterol is best known in connection with cardiovascular disease, but cholesterol is also vital for many fundamental processes in the body.
Did cholesterol levels improve among us kids, adolescents?
This study examined cholesterol levels in children and adolescents in the US from 1999 to 2016.
Seed oils are best for LDL cholesterol
Using a statistical technique called network meta-analysis, researchers have combined the results of dozens of studies of dietary oils to identify those with the best effect on patients' LDL cholesterol and other blood lipids.
Cholesterol leash: Key tethering protein found to transport cellular cholesterol
Cholesterol is an essential component of living organisms, but the mechanisms that transport cholesterol inside the cell are poorly understood.
New way to treat cholesterol may be on the horizon
A breakthrough discovery by scientists at Houston Methodist Research Institute could change the way we treat cholesterol.
More Cholesterol News and Cholesterol Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Erasing The Stigma
Many of us either cope with mental illness or know someone who does. But we still have a hard time talking about it. This hour, TED speakers explore ways to push past — and even erase — the stigma. Guests include musician and comedian Jordan Raskopoulos, neuroscientist and psychiatrist Thomas Insel, psychiatrist Dixon Chibanda, anxiety and depression researcher Olivia Remes, and entrepreneur Sangu Delle.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...