Nav: Home

Staphyloccus ribosome structure researched by KFU Structural Biology Lab

June 05, 2017

The results were published in Nucleic Acids Research. This paper was announced as the best of May 2017 by FSBMB.

Bacterial ribosome is a macromolecular complex containing 3 RNA molecules and about 50 individual proteins. Before this KFU research the structure of gram-negative bacteria's ribosomes had been researched in atomic definition only through X-ray crystallography, and cryo-electron microscopy had given medium definition results.

Marat Yusupov, Head of the Structural Biology Lab and Head of the Ribosome Structure Lab at IGBMC, commented in 2016, "In our work we used modern biophysical and biochemical methods; the Lab staff is inter-Institute. It includes biologists and physicists, and chemists are expected to join as well. Currently our work is mostly conducted together with the Biochemistry Lab; NMR is used. The main constraint of this project now is that KFU doesn't have cryo-electron microscopy which would allow researching frozen specimens and discover the structure of macromolecular complexes with very high precision, basically on the molecular level. X-ray crystallography allows studying protein structure on its chemical atomic level, when each atom can be positioned in 3D which gives the opportunity to predict which inhibitors and small molecules can deactivate the protein. There are not many research centers which possess all the three technologies, as well as not many of those who study ribosome structures. The problem is both in the object and in the research methods".

By presenting the Staphylococcus ribosome structure in HD cryo-electron microscopy the researchers have significantly advanced in their work - the one which is of great significance for medicine, starting from mild skin diseases and ending with lethal infections like pneumonia, meningitis, osteomyelitis, endocarditis, toxic shock, and septicemia.

The scientists try to find a way to «disable» protein synthesis in Staphylococcus cells and thus a way to kill it.

There are many drug-resistant strains of Staphylococcus circulating in the population, so this research can lead to saving millions of lives in the long run.

Kazan Federal University

Related Protein Articles:

Protein aggregation: Protein assemblies relevant not only for neurodegenerative disease
Amyloid fibrils play a crucial role in neurodegenerative illnesses. Scientists from Heinrich Heine University Düsseldorf (HHU) and Forschungszentrum Jülich have now been able to use cryo-electron microscopy (cryo-EM) to decode the spatial structure of the fibrils that are formed from PI3K SH3 domains - an important model system for research.
Old protein, new tricks: UMD connects a protein to antibody immunity for the first time
How can a protein be a major contributor in the development of birth defects, and also hold the potential to provide symptom relief from autoimmune diseases like lupus?
Infection-fighting protein also senses protein misfolding in non-infected cells
Researchers at the University of Toronto have uncovered an immune mechanism by which host cells combat bacterial infection, and at the same time found that a protein crucial to that process can sense and respond to misfolded proteins in all mammalian cells.
Quorn protein builds muscle better than milk protein
A study from the University of Exeter has found that mycoprotein, the protein-rich food source that is unique to Quorn products, stimulates post-exercise muscle building to a greater extent than milk protein.
More than a protein factory
Researchers from the Stowers Institute for Medical Research have discovered a new function of ribosomes in human cells that may show the protein-making particle's role in destroying healthy mRNAs, the messages that decode DNA into protein.
More Protein News and Protein Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Rethinking Anger
Anger is universal and complex: it can be quiet, festering, justified, vengeful, and destructive. This hour, TED speakers explore the many sides of anger, why we need it, and who's allowed to feel it. Guests include psychologists Ryan Martin and Russell Kolts, writer Soraya Chemaly, former talk radio host Lisa Fritsch, and business professor Dan Moshavi.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...