Nav: Home

Staphyloccus ribosome structure researched by KFU Structural Biology Lab

June 05, 2017

The results were published in Nucleic Acids Research. This paper was announced as the best of May 2017 by FSBMB.

Bacterial ribosome is a macromolecular complex containing 3 RNA molecules and about 50 individual proteins. Before this KFU research the structure of gram-negative bacteria's ribosomes had been researched in atomic definition only through X-ray crystallography, and cryo-electron microscopy had given medium definition results.

Marat Yusupov, Head of the Structural Biology Lab and Head of the Ribosome Structure Lab at IGBMC, commented in 2016, "In our work we used modern biophysical and biochemical methods; the Lab staff is inter-Institute. It includes biologists and physicists, and chemists are expected to join as well. Currently our work is mostly conducted together with the Biochemistry Lab; NMR is used. The main constraint of this project now is that KFU doesn't have cryo-electron microscopy which would allow researching frozen specimens and discover the structure of macromolecular complexes with very high precision, basically on the molecular level. X-ray crystallography allows studying protein structure on its chemical atomic level, when each atom can be positioned in 3D which gives the opportunity to predict which inhibitors and small molecules can deactivate the protein. There are not many research centers which possess all the three technologies, as well as not many of those who study ribosome structures. The problem is both in the object and in the research methods".

By presenting the Staphylococcus ribosome structure in HD cryo-electron microscopy the researchers have significantly advanced in their work - the one which is of great significance for medicine, starting from mild skin diseases and ending with lethal infections like pneumonia, meningitis, osteomyelitis, endocarditis, toxic shock, and septicemia.

The scientists try to find a way to «disable» protein synthesis in Staphylococcus cells and thus a way to kill it.

There are many drug-resistant strains of Staphylococcus circulating in the population, so this research can lead to saving millions of lives in the long run.

Kazan Federal University

Related Protein Articles:

A direct protein-to-protein binding couples cell survival to cell proliferation
The regulators of apoptosis watch over cell replication and the decision to enter the cell cycle.
A protein that controls inflammation
A study by the research team of Prof. Geert van Loo (VIB-UGent Center for Inflammation Research) has unraveled a critical molecular mechanism behind autoimmune and inflammatory diseases such as rheumatoid arthritis, Crohn's disease, and psoriasis.
Resurrecting ancient protein partners reveals origin of protein regulation
After reconstructing the ancient forms of two cellular proteins, scientists discovered the earliest known instance of a complex form of protein regulation.
Sensing protein wellbeing
The folding state of the proteins in live cells often reflect the cell's general health.
Protein injections in medicine
One day, medical compounds could be introduced into cells with the help of bacterial toxins.
Discovery of an unusual protein
Scientists from Bremen discover an unusual protein playing a significant role in the Earth's nitrogen cycle.
Protein aggregation: Protein assemblies relevant not only for neurodegenerative disease
Amyloid fibrils play a crucial role in neurodegenerative illnesses. Scientists from Heinrich Heine University Düsseldorf (HHU) and Forschungszentrum Jülich have now been able to use cryo-electron microscopy (cryo-EM) to decode the spatial structure of the fibrils that are formed from PI3K SH3 domains - an important model system for research.
Old protein, new tricks: UMD connects a protein to antibody immunity for the first time
How can a protein be a major contributor in the development of birth defects, and also hold the potential to provide symptom relief from autoimmune diseases like lupus?
Infection-fighting protein also senses protein misfolding in non-infected cells
Researchers at the University of Toronto have uncovered an immune mechanism by which host cells combat bacterial infection, and at the same time found that a protein crucial to that process can sense and respond to misfolded proteins in all mammalian cells.
Quorn protein builds muscle better than milk protein
A study from the University of Exeter has found that mycoprotein, the protein-rich food source that is unique to Quorn products, stimulates post-exercise muscle building to a greater extent than milk protein.
More Protein News and Protein Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: Reinvention
Change is hard, but it's also an opportunity to discover and reimagine what you thought you knew. From our economy, to music, to even ourselves–this hour TED speakers explore the power of reinvention. Guests include OK Go lead singer Damian Kulash Jr., former college gymnastics coach Valorie Kondos Field, Stockton Mayor Michael Tubbs, and entrepreneur Nick Hanauer.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Dispatch 6: Strange Times
Covid has disrupted the most basic routines of our days and nights. But in the middle of a conversation about how to fight the virus, we find a place impervious to the stalled plans and frenetic demands of the outside world. It's a very different kind of front line, where urgent work means moving slow, and time is marked out in tiny pre-planned steps. Then, on a walk through the woods, we consider how the tempo of our lives affects our minds and discover how the beats of biology shape our bodies. This episode was produced with help from Molly Webster and Tracie Hunte. Support Radiolab today at