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Putting lungs under less stress

June 05, 2018

The numbers are grim: Of the 200,000 Americans diagnosed with Acute Respiratory Distress Syndrome (ARDS) each year, 30 to 50 percent will die. But, clinical researchers at the University of Missouri School of Medicine's division of Pulmonary, Critical Care and Environmental Medicine identified a less-invasive treatment option for patients with severely impaired lung function.

"Treating patients with ARDS has been historically difficult," said Hariharan Regunath, MD, an assistant professor of clinical medicine at the MU School of Medicine and medical director of the Progressive Care Unit at University Hospital. "These patients tend to be already very sick, and the nature of current interventions means a grueling recovery and possibly being transported to a far-away facility for specialized care. However, what we observed is that it's possible in some cases to significantly decrease the amount of air used by the ventilators used in this process, thereby mitigating further lung injury, which in turn might improve outcomes and access to care."

In a study that included 15 patients, Regunath and his team were able to use lower pressure volumes of ventilation than what is standard - 6 mL per kilogram of the patient's ideal weight - to in some cases as low as 2 mL per kilogram. The researchers referred to this option as "ultra-protective mechanical ventilation," as it creates less risk for typical lung injuries such as hyperinflation and barotrauma.

Regunath noted that this is significant because patients did not require extracorporeal carbon dioxide removal, or ECCO2R, which removes the CO2 produced by the human body using a device commonly called ECMO (extracorporeal membrane oxygenation). Gas exchange is important, as the patient's blood can become acidic if excess carbon dioxide is allowed to build up. However, many referral facilities in the United States and worldwide do not have the ECMO equipment or the expertise for ECCO2R in-house, and often those patients who would most benefit from this type of treatment are too sick for transporting to far-away hospitals with established expertise.

The patients Regunath and his team observed showed only slightly elevated carbon dioxide levels despite not using ECCO2R, and the mortality rate for these patients did not increase.

"The results of this preliminary study highlight two important points," Regunath said. "One, smaller hospitals and referral hospitals in rural areas caring for sick ARDS patients might be able to continue to treat patients closer to their homes rather than transporting them to far away hospitals for ECCO2R. Two, patients who already are struggling to recover from severe illnesses such as ARDS might not have to undergo invasive treatments such as ECCO2R, which carry the potential to make them even sicker from device-related complications. Ultimately, it's important to take an individualized approach to patient care for ARDS."

In addition to Regunath, other researchers in the study included Mohammed Alnijoumi, MD; Troy Whitacre, RRT; and Jonathan Collins, MD.

The study authors declared no potential conflicts of interest with respect to research, authorship and/or publication of this article and received no financial support for the research. The study, "Ultra-protective Mechanical Ventilation without Extra-corporeal Carbon Dioxide Removal for Acute Respiratory Distress Syndrome," was recently published in the Journal of the Intensive Care Society.
-end-


University of Missouri-Columbia

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