Nav: Home

Promising molecule targets protein to offer hope for people with Parkinson's

June 05, 2019

Results from a study published today looking at a molecule targeting clumps of alpha-synuclein, a key protein linked to Parkinson's, offers hope that it may be possible to slow down or prevent the progression of the condition in humans.

Researchers at the University of Cambridge have been able to investigate the effect of a molecule called anle138b, by developing a new mouse model of Parkinson's.

Funded by the charity Parkinson's UK, the study looked at the effect of anle138b on the accumulation of alpha-synuclein, a protein known to form sticky clumps, known as Lewy bodies, in the brain. These clumps are associated with the death of nerve cells responsible for producing the chemical dopamine, which allows messages to be sent to the parts of the brain that help co-ordinate movement. This causes the motor symptoms associated with Parkinson's, including freezing, tremors and slowness of movement.

Anle138b has previously been shown to reduce the clumping of proteins in neurodegenerative conditions, including other Parkinson's models. To further study the potential of the molecule for treating the condition, researchers created a new mouse model of Parkinson's that mimics the way alpha-synuclein gradually accumulates specifically in areas of the brain typically affected by the condition.

At nine-months-old, without treatment, the levels of dopamine in the mouse model brains were already reduced. This reduction was associated with the onset of symptoms, including a subtle change in gait that mimicked some of the early motor symptoms seen in people with Parkinson's - such as the 'shuffling' of feet when walking.

When the mice were treated for three months with anle138b, starting at nine-months-old, before significant nerve cell loss had occurred, researchers observed a reduction in alpha-synuclein clumps, restored levels of dopamine in the brain and protection against nerve cell death. This was accompanied by an improvement to the gait of the mice, effectively reversing several of the Parkinson's like motor symptoms.

These promising results published in Acta Neuropathologica today, suggest that if anle138b is given early on before consistent nerve cell death, it can reduce the dense clumping of the alpha-synuclein aggregates, potentially stopping Parkinson's in its tracks.

Lead Researcher, Professor Maria Grazia Spillantini of the Department of Clinical Neurosciences, University of Cambridge, said: "Our study demonstrates that by affecting early alpha-synuclein aggregation with the molecule anle138b in a novel transgenic mouse model, one can rescue the dopaminergic dysfunction and motor features that are typical of Parkinson's.

"By using super resolution microscopy, we have been able to see how the compound acts in the brain of the mouse to achieve this effect. This work opens the way for the development of new mechanism-based therapies for Parkinson's and related disorders."

Dr Beckie Port, Research Manager at Parkinson's UK, said: "The evidence from this early stage study builds on our understanding of how alpha-synuclein is involved in Parkinson's and provides a new model that could unlock future treatments.

"Additionally, the discovery that targeting alpha-synuclein aggregation early on can restore dopamine levels and rescue cells may prove to be crucial in stopping Parkinson's in its tracks.

"Today, we have no treatments that can slow or stop the progression of Parkinson's. It is vital we continue to support world-leading academics, like those in Cambridge, and ensure results like these are turned into future treatments that are so desperately needed for the 1 in 37 of us that will be diagnosed in our lifetime."
For more information and interviews, please contact:

Anita Salhotra, Senior Media and PR Officer at Parkinson's UK, on 020 7932 1361 or 07961 460248 (out of hours) or email

Notes to editors

This press release highlights the findings reported in a paper published on Wednesday 5th June 2019:

'Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model' - published in Acta Neuropathologica

The partners

The study was funded by Parkinson's UK and led by Maria Grazia Spillantini FMedSci FRS, Professor of Molecular Neurology.

This was in collaboration with:

Christian Griesinger from Max Planck Institute for Biophysical Chemistry, Goettingen where anle138b was developed and synthesised.

Armin Giese at Ludwig-Maximilian University in Munich, Germany where the drug was developed. He is also in charge of the pre-clinical and clinical development of anle138b.

Uri Ashery at Tel-Aviv University where the new platform dSTORM (super resolution microscopy) was developed and applied to the mouse sections.

About Parkinson's

Every hour, two people in the UK are told they have Parkinson's.

It affects 145,000 people in the UK - which is around one in 350 of the adult population.

Parkinson's is a degenerative neurological condition, for which there currently is no cure. The main symptoms of the condition are tremor, slowness of movement and rigidity.

About Parkinson's UK

Parkinson's UK is the UK's leading charity supporting those with the condition. Its mission is to find a cure and improve life for everyone affected by Parkinson's through cutting edge research, information, support and campaigning.

For advice, information and support, visit or call our free, confidential helpline on 0808 800 0303.

Parkinson's UK

Related Dopamine Articles:

Novelty speeds up learning thanks to dopamine activation
Brain scientists led by Sebastian Haesler (NERF, empowered by IMEC, KU Leuven and VIB) have identified a causal mechanism of how novel stimuli promote learning.
Evidence in mice that childhood asthma is influenced by the neurotransmitter dopamine
Neurons that produce the neurotransmitter dopamine communicate with T cells to enhance allergic inflammation in the lungs of young mice but not older mice, researchers report Nov.
Chronic adversity dampens dopamine production
People exposed to a lifetime of psychosocial adversity may have an impaired ability to produce the dopamine levels needed for coping with acutely stressful situations.
Blocking dopamine weakens effects of cocaine
Blocking dopamine receptors in different regions of the amygdala reduces drug seeking and taking behavior with varying longevity, according to research in rats published in eNeuro.
How chronic inflammation may drive down dopamine and motivation
A new computational method will allow scientists to measure the effects of chronic inflammation on energy availability and effort-based decision-making.
Dopamine regulates sex differences in worms
Dopamine is responsible for sex-specific variations in common behaviors, finds a study of worm movements published in JNeurosci.
Dopamine conducts prefrontal cortex ensembles
New research in rodents reveals for the first time how dopamine changes the function of the brain's prefrontal cortex.
Dopamine modulates reward experiences elicited by music
New study in Proceedings of the National Academy of Science reveals causal link between dopamine and human reward response to music listening.
Dopamine modulates the reward experiences elicited by music
Researchers from IDIBELL-UB, the Sant Pau Hospital and the McGill University published a new study in PNAS that shows for the first time a causal link between the dopaminergic system and enjoying music.
Dopamine's yin-yang personality: It's an upper and a downer
Dopamine has a reputation as the key player in the brain's reward circuits, making us seek out pleasurable experiences, but growing evidence points to a multipronged role for the neurotransmitter.
More Dopamine News and Dopamine Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

There's so much we've yet to explore–from outer space to the deep ocean to our own brains. This hour, Manoush goes on a journey through those uncharted places, led by TED Science Curator David Biello.
Now Playing: Science for the People

#556 The Power of Friendship
It's 2020 and times are tough. Maybe some of us are learning about social distancing the hard way. Maybe we just are all a little anxious. No matter what, we could probably use a friend. But what is a friend, exactly? And why do we need them so much? This week host Bethany Brookshire speaks with Lydia Denworth, author of the new book "Friendship: The Evolution, Biology, and Extraordinary Power of Life's Fundamental Bond". This episode is hosted by Bethany Brookshire, science writer from Science News.
Now Playing: Radiolab

Dispatch 1: Numbers
In a recent Radiolab group huddle, with coronavirus unraveling around us, the team found themselves grappling with all the numbers connected to COVID-19. Our new found 6 foot bubbles of personal space. Three percent mortality rate (or 1, or 2, or 4). 7,000 cases (now, much much more). So in the wake of that meeting, we reflect on the onslaught of numbers - what they reveal, and what they hide.  Support Radiolab today at