Nav: Home

Lower risk of heart disease and stroke in people with Type 2 diabetes taking atorvastatin

June 06, 2004

A daily dose of the cholesterol-lowering drug atorvastatin (Lipitor) can reduce the risk of a first major cardiovascular event (heart attack or stroke) by more than one third in people with Type 2 diabetes, according to the results of the CARDS study presented today at the American Diabetes Association's 64th Scientific Sessions in Orlando, USA.

CARDS (Collaborative AtoRvastatin Diabetes Study) was sponsored by the charity Diabetes UK, the Department of Health and Pfizer. The study found that a daily 10mg dose of atorvastatin reduced the risk of a major cardiovascular event by 37%; for instance, serious heart problems were reduced by more than one third (36%) and strokes by almost half (48%). Importantly, these benefits were observed even amongst patients whose LDL-cholesterol levels were already quite low before treatment.

Professor John Betteridge, CARDS co-principal investigator and Professor of Endocrinology and Metabolism at UCL, says: "This exciting study has very important implications for the cardiovascular health of people with Type 2 diabetes. For all patients with Type 2 diabetes consideration should now be given to whether they warrant statin therapy. What this study shows is in this case, atorvastatin treatment is safe and highly effective at reducing the risk of cardiovascular disease."

The trial, co-ordinated at UCL, was carried out in 132 centres in the UK and Ireland and involved 2,838 people with Type 2 diabetes, each taking a daily dose of 10mg of atorvastatin or placebo. Participants entered CARDS with no previous history of heart disease or stroke, but with some cardiovascular risk factors other than diabetes and with relatively low levels of cholesterol.

The study was due to run until 2005 but was stopped in June 2003 when interim results showed a significant reduction in the risk of heart attacks, strokes or the need for cardiovascular surgery in participants taking atorvastatin.

There are 1.4 million people in the UK diagnosed with diabetes. People with Type 2 diabetes (the most common form of the disease) are at significantly increased risk of developing cardiovascular disease compared to people without diabetes.

CARDS is the first clinical trial specifically designed to investigate the effectiveness of cholesterol lowering with a statin in people with Type 2 diabetes who have no previous history of heart disease or stroke.

Paper describing the design of CARDS available at: http://www.blackwell-synergy.com/

Baseline data - the characteristics of patients entering the study - will be published in the journal Diabetic Medicine in July.

The main results of the study will be published later this year.
-end-
See the CARDS Website www.cardstrial.org for further information.

CARDS Executive Committee
Professor John Betteridge,* University College London
Professor Helen Colhoun,* CARDS Co-ordinating Centre, University College London
Professor Paul Durrington,* CARDS Central Laboratory, University of Manchester
Professor John Fuller,* CARDS Co-ordinating Centre, University College London
Professor Graham Hitman,* Barts and The London, Queen Mary's School of Medicine & Dentistry
Ms Dot Lambert, Department of Health - Study Sponsor
Dr Moira Murphy, Diabetes UK - Study Sponsor
Dr Andrew Neil,* University of Oxford Dr Craig Stevenson, Pfizer UK Ltd - Study Sponsor
* Co-principal investigator

For more information, please contact:
Jenny Gimpel (University College London Press Office) on tel 44-207-679-9739, Mobile 44-799-067-5947

University College London

Related Diabetes Articles:

Tele-diabetes to manage new-onset diabetes during COVID-19 pandemic
Two new case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in an adult and an infant during the COVID-19 pandemic.
Genetic profile may predict type 2 diabetes risk among women with gestational diabetes
Women who go on to develop type 2 diabetes after having gestational, or pregnancy-related, diabetes are more likely to have particular genetic profiles, suggests an analysis by researchers at the National Institutes of Health and other institutions.
Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).
Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.
People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.
Diabetes, but not diabetes drug, linked to poor pregnancy outcomes
New research indicates that pregnant women with pre-gestational diabetes who take metformin are at a higher risk for adverse pregnancy outcomes -- such as major birth defects and pregnancy loss -- than the general population, but their increased risk is not due to metformin but diabetes.
New oral diabetes drug shows promise in phase 3 trial for patients with type 1 diabetes
A University of Colorado Anschutz Medical Campus study finds sotagliflozin helps control glucose and reduces the need for insulin in patients with type 1 diabetes.
Can continuous glucose monitoring improve diabetes control in patients with type 1 diabetes who inject insulin
Two studies in the Jan. 24/31 issue of JAMA find that use of a sensor implanted under the skin that continuously monitors glucose levels resulted in improved levels in patients with type 1 diabetes who inject insulin multiple times a day, compared to conventional treatment.
Complications of type 2 diabetes affect quality of life, care can lead to diabetes burnout
T2D Lifestyle, a national survey by Health Union of more than 400 individuals experiencing type 2 diabetes (T2D), reveals that patients not only struggle with commonly understood complications, but also numerous lesser known ones that people do not associate with diabetes.
A better way to predict diabetes
An international team of researchers has discovered a simple, accurate new way to predict which women with gestational diabetes will develop type 2 diabetes after delivery.
More Diabetes News and Diabetes Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: Meditations on Loneliness
Original broadcast date: April 24, 2020. We're a social species now living in isolation. But loneliness was a problem well before this era of social distancing. This hour, TED speakers explore how we can live and make peace with loneliness. Guests on the show include author and illustrator Jonny Sun, psychologist Susan Pinker, architect Grace Kim, and writer Suleika Jaouad.
Now Playing: Science for the People

#565 The Great Wide Indoors
We're all spending a bit more time indoors this summer than we probably figured. But did you ever stop to think about why the places we live and work as designed the way they are? And how they could be designed better? We're talking with Emily Anthes about her new book "The Great Indoors: The Surprising Science of how Buildings Shape our Behavior, Health and Happiness".
Now Playing: Radiolab

The Third. A TED Talk.
Jad gives a TED talk about his life as a journalist and how Radiolab has evolved over the years. Here's how TED described it:How do you end a story? Host of Radiolab Jad Abumrad tells how his search for an answer led him home to the mountains of Tennessee, where he met an unexpected teacher: Dolly Parton.Jad Nicholas Abumrad is a Lebanese-American radio host, composer and producer. He is the founder of the syndicated public radio program Radiolab, which is broadcast on over 600 radio stations nationwide and is downloaded more than 120 million times a year as a podcast. He also created More Perfect, a podcast that tells the stories behind the Supreme Court's most famous decisions. And most recently, Dolly Parton's America, a nine-episode podcast exploring the life and times of the iconic country music star. Abumrad has received three Peabody Awards and was named a MacArthur Fellow in 2011.