Sanford health seeks cure for type 1 diabetes

June 06, 2008

Sanford Health leaders announced today the focus of the Sanford Project is curing type 1 diabetes via the body's natural ability to regenerate beta cells. Identified as the attack on one of the greatest health concerns of our time, Sanford Health is dedicating health research resources to cure type 1 diabetes, also known as juvenile diabetes.

"The concept for the Sanford Project is to focus on a single, pressing healthcare issue and establish a world-class research team to achieve significant progress within a reasonable time period," said Sanford Health Executive Vice President Dave Link. "Through an extensive selection process which outlined specific candidate criteria, Sanford Health has chosen to attack type 1 diabetes by focusing on beta cell regeneration."

Type 1 diabetes currently affects nearly 3 million people in the United States. It is an autoimmune disease in which the body's immune system attacks and destroys insulin-producing cells of the pancreas. It often strikes during childhood, makes patients dependent on insulin for life and carries the constant threat of devastating complications. Regeneration research focuses on triggering the body to re-grow the insulin-producing beta cells that have been killed by the autoimmune response and to prevent destruction of the newly regenerated cells by the same autoimmune reaction.

"Beta cell regeneration is one of the fastest-growing and most intriguing areas of type 1 diabetes research," stated Ben Perryman, PhD, Sanford Health Vice President of Research. "Through the Sanford Project, our research team will hope to either spur the body to copy existing functioning beta cells or to coax the pancreas to create new ones. When people with the disease have regenerated beta cells, they can begin making their own insulin again. The intent of the Sanford Project will be to focus on bench-side research and closely integrating translational research opportunities with clinical treatment."

Sanford Health will assemble a team of top researchers to work on the project and plans an investment of $30 million over five to seven years. Addi¬tional funding is expected from foundation and industry sources as well as the National Institutes of Health. The core of the research will be conducted in a developing 185-acre research park in the city's growing southwest corridor.

Sanford Health will be partnering in the recruitment of researchers and review of regeneration-related research with the Juvenile Diabetes Research Foundation International (JDRF). JDRF is the world's largest charitable source of funding for research leading to a cure for type 1 diabetes and its complications.

"JDRF welcomes Sanford Health as its very special partner in a shared mission. We both aim to accelerate the discovery, development and delivery of new, life-changing therapies and cures for all who suffer from type 1 diabetes and its complications," said S. Robert Levine, MD, Chairman of the JDRF Clinical Affairs Working Group. "The Sanford Project has great potential to help us keep our promise of a cure. It uniquely affords us [Sanford, JDRF, Burnham and other collaborators] the opportunity to link the critical resources required to bridge all the gaps in translating scientific advances made at the laboratory bench into new drug and device development breakthroughs, and ultimately reach the right patient, at the right time, and every time."

The Sanford Project is one of four initiatives outlined after a transformational gift of $400 million by South Dakota businessman and philanthropist Denny Sanford in 2007. From its inception, the Sanford Project was "designed for results." Viable candidate ideas were assessed based on criteria including: (1) a specific approach to advance new treatments for a disease, (2) a high likelihood of success within a designated time frame and (3) an appropriate and suitable scope to be carried out at Sanford Health.

To select a final disease for the Sanford Project, a committee of leading scientists, named the Advisory Council, met on April 17, 2008. Presentations were heard from leading national experts representing each of the final four candidate ideas which included: lupus, pediatric multiple sclerosis, and cancer caused by HPV (human papillomavirus). The Advisory Council deliberated and presented its guidance and recommendations. Based on these recommendations, the Sanford Health Board of Trustees made its final selection.
-end-
About Sanford Health
Sanford Health's comprehensive, integrated system includes nearly 370 physicians in 115 clinics, 23 hospitals, 13 nursing homes, 17 assisted living facilities and congregate living locations, 27 home health services and 19 pharmacies. With approximately 12,000 employees, Sanford Health is the largest employer in the region. Its primary 500-bed nonprofit tertiary care hospital in Sioux Falls, SD, serves an average of more than 30,000 inpatients annually. With more than a million outpatient visits each year, Sanford Health has served the 80,000 square mile, four-state region of South Dakota, Iowa, Minnesota and Nebraska for over 110 years. Sanford Health is the largest healthcare system between Mayo Clinic in Rochester, MN, and Denver, CO. Its divisions include Sanford USD Medical Center, Sanford Clinic, Sanford Health Network, Sanford Health Plan and Sanford Health Foundation. For more information, visit www.sanfordhealth.org.

JDRF

Related Diabetes Articles from Brightsurf:

New diabetes medication reduced heart event risk in those with diabetes and kidney disease
Sotagliflozin - a type of medication known as an SGLT2 inhibitor primarily prescribed for Type 2 diabetes - reduces the risk of adverse cardiovascular events for patients with diabetes and kidney disease.

Diabetes drug boosts survival in patients with type 2 diabetes and COVID-19 pneumonia
Sitagliptin, a drug to lower blood sugar in type 2 diabetes, also improves survival in diabetic patients hospitalized with COVID-19, suggests a multicenter observational study in Italy.

Making sense of diabetes
Throughout her 38-year nursing career, Laurel Despins has progressed from a bedside nurse to a clinical nurse specialist and has worked in medical, surgical and cardiac intensive care units.

Helping teens with type 1 diabetes improve diabetes control with MyDiaText
Adolescence is a difficult period of development, made more complex for those with Type 1 diabetes mellitus (T1DM).

Diabetes-in-a-dish model uncovers new insights into the cause of type 2 diabetes
Researchers have developed a novel 'disease-in-a-dish' model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease.

Tele-diabetes to manage new-onset diabetes during COVID-19 pandemic
Two new case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in an adult and an infant during the COVID-19 pandemic.

Genetic profile may predict type 2 diabetes risk among women with gestational diabetes
Women who go on to develop type 2 diabetes after having gestational, or pregnancy-related, diabetes are more likely to have particular genetic profiles, suggests an analysis by researchers at the National Institutes of Health and other institutions.

Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).

Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.

People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.

Read More: Diabetes News and Diabetes Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.