Oatmeal-labeling ideal for molecular imaging of stomach emptying

June 06, 2011

San Antonio, Texas (June 6, 2011)--Patients undergoing molecular imaging to evaluate their stomach's ability to clear food are going to have an altogether new kind of breakfast. A study presented at SNM's 58th Annual Meeting has confirmed that nuclear medicine technologists can effectively use oatmeal products radiolabeled with a medical isotope to target and image the emptying of the stomach.

"The current standard for molecular imaging of gastric emptying is radiolabeling egg meal, but there are patients who, either due to lifestyle choices or allergies, cannot eat eggs," says Tory Maloy, senior nuclear medicine technologist at Northwestern Memorial Hospital, Chicago, Ill. "With this research we have demonstrated that there is an equally effective way to label oatmeal for gastric emptying studies."

Molecular imaging of gastric emptying is a common procedure, and current scientific literature advises nuclear medicine technologists to radiolabel egg meal as an imaging agent for patient consumption prior to imaging. This study marks the first of its kind examining the proper method for radiolabeling instant oatmeal products, both traditional and gluten-free.

During the study, researchers used an imaging agent called Tc99m SC (sulfur colloid) both before and after boiling water for oatmeal preparation. Small amounts of water were added to samples of the oatmeal products. Separation of the oatmeal that was bound successfully with the agent from the remaining unbound agent was achieved with low-speed centrifugation for two minutes. Radiolabeling activity was gauged with a dose calibrator and compared to that of standard radiolabeled egg meal.

Results of the study showed that radiolabeling was significantly improved by labeling prior to boiling water and that radiolabeled oatmeal was just as effective as egg meal for the molecular imaging of gastric emptying. This study expands the current scientific literature regarding radiolabeling for gastric emptying studies and provides patients a safe and effective alternative to imaging with radiolabeled egg meal.
-end-
Scientific Paper 2334: T. Maloy, M. Herrera, M. Zimmer, S. Spies, Northwestern Memorial Hospital, Chicago, IL; "Optimal radiolabeling methods for Tc99m Sulfur Colloid oatmeal products for gastric emptying," SNM's 58th Annual Meeting, June 4-8, 2011, San Antonio, TX.

Society of Nuclear Medicine

Related Molecular Imaging Articles from Brightsurf:

New technique offers higher resolution molecular imaging and analysis
The new approach from Northwestern Engineering could help researchers understand more complicated biomolecular interactions and characterize cells and diseases at the single-molecule level.

Molecular imaging offers insight into therapy outcomes for neuroendocrine tumor patients
A new proof-of-concept study published in the May issue of The Journal of Nuclear Medicine has demonstrated that molecular imaging can be used for identifying early response to 177Lu-DOTATATE treatment in neuroendocrine tumor patients.

Non-invasive imaging method spots cancer at the molecular level
Researchers for the first time have combined a powerful microscopy technique with automated image analysis algorithms to distinguish between healthy and metastatic cancerous tissue without relying on invasive biopsies or the use of a contrast dye.

Molecular imaging suggests smokers may have impaired neuroimmune function
Research presented at the 2019 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNM MI) shows preliminary evidence that tobacco smokers may have reduced neuroimmune function compared with nonsmokers.

Novel noninvasive molecular imaging for monitoring rheumatoid arthritis
A first-in-human Phase 1/Phase II study demonstrates that intravenous administration of the radiopharmaceutical imaging agent technetium-99m (99mTc) tilmanocept promises to be a safe, well-tolerated, noninvasive means of monitoring rheumatoid arthritis disease activity.

Improving molecular imaging using a deep learning approach
Generating comprehensive molecular images of organs and tumors in living organisms can be performed at ultra-fast speed using a new deep learning approach to image reconstruction developed by researchers at Rensselaer Polytechnic Institute.

Nanoplatform developed with three molecular imaging modalities for tumor diagnosis
Nanotechnology and biotechnology are bringing us increasingly closer to personalised cancer treatment.

Study suggests molecular imaging strategy for determining molecular classifications of NSCLC
Recent findings suggest a novel positron emission tomography (PET) imaging approach determining epidermal growth factor receptor (EGFR) mutation status for improved lung cancer patient management.

New imaging technique able to watch molecular dynamics of neurodegenerative diseases
Researchers have developed a fast and practical molecular-scale imaging technique that could let scientists view never-before-seen dynamics of biological processes involved in neurodegenerative diseases such as Alzheimer's disease and multiple sclerosis.

Combined optical and molecular imaging could guide breast-conserving surgery
Breast-conserving surgery is the primary treatment for early-stage breast cancer, but more accurate techniques are needed to assess resection margins during surgery to avoid the need for follow-up surgeries.

Read More: Molecular Imaging News and Molecular Imaging Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.