Modeling the demise of migrating brain tumor cells

June 06, 2012

An Israeli physicist has developed a theoretical model to simulate the evolution of highly proliferating brain tumour core cells subjected to treatment by alternating radio frequency electric field. The research, by Alexander Iomin from the Israel Institute of Technology Technion in Haifa, is about to be published in EPJ E¹. In another model, the author examines the possibility of enhancing the level of treatment by targeting the outer area of the tumour.

Iomin introduced a theoretical evaluation of the effect of a standard treatment known as tumour-treating-field (TTF) on the speed of development of a type of brain tumour called glioma. To do so, he adapted a well-established model -- the so-called fractal comb model, which looks like the regularly spaced teeth of a comb -- based on a mathematical approach called fractional calculus. This model is based on the hypothesis that TTF treatment had limited efficiency in the outer region and would only be effective on the inner part of the tumour, which is characterised by a higher proliferation rate of cancer cells.

By contrast, the peripheral part of the tumour is characterised by high migration and low proliferation rates of cancer cells. In his second model, the author considered glioma cancer as a composite of cancer cells and normal tissue cells. Each cell type exhibits a distinctive polarisation by an electric field, following a pattern similar to fractal geometry. He established a model reflecting the difference between the two types of cells and applied fractal calculus to their geometry. Iomin suggested that because of the fractal nature of cancer cells the TTF treatment might be enhanced at certain frequencies. As a result, the cancer cells' plasma membrane permeability would irreversibly increase, which could lead to their demise. This approach may constitute an effective non-invasive method for treating brain cancer.
-end-
References

1. Iomin A., A toy model of fractal glioma development under RF electricfield treatment (2012), European Physical Journal E (EPJ E) 35: 42, DOI 10.1140/epje/i2012-12042-9

For more information, please visit www.epj.org

Springer

Related Cancer Cells Articles from Brightsurf:

Cancer researchers train white blood cells to attacks tumor cells
Scientists at the National Center for Tumor Diseases Dresden (NCT/UCC) and Dresden University Medicine, together with an international team of researchers, were able to demonstrate that certain white blood cells, so-called neutrophil granulocytes, can potentially - after completing a special training program -- be utilized for the treatment of tumors.

New way to target some rapidly dividing cancer cells, leaving healthy cells unharmed
Scientists at Johns Hopkins Medicine and the University of Oxford say they have found a new way to kill some multiplying human breast cancer cells by selectively attacking the core of their cell division machinery.

Breast cancer cells use message-carrying vesicles to send oncogenic stimuli to normal cells
According to a Wistar study, breast cancer cells starved for oxygen send out messages that induce oncogenic changes in surrounding normal epithelial cells.

Breast cancer cells turn killer immune cells into allies
Researchers at Johns Hopkins University School of Medicine have discovered that breast cancer cells can alter the function of immune cells known as Natural killer (NK) cells so that instead of killing the cancer cells, they facilitate their spread to other parts of the body.

Breast cancer cells can reprogram immune cells to assist in metastasis
Johns Hopkins Kimmel Cancer Center investigators report they have uncovered a new mechanism by which invasive breast cancer cells evade the immune system to metastasize, or spread, to other areas of the body.

Engineered immune cells recognize, attack human and mouse solid-tumor cancer cells
CAR-T therapy has been used successfully in patients with blood cancers such as lymphoma and leukemia.

Drug that keeps surface receptors on cancer cells makes them more visible to immune cells
A drug that is already clinically available for the treatment of nausea and psychosis, called prochlorperazine (PCZ), inhibits the internalization of receptors on the surface of tumor cells, thereby increasing the ability of anticancer antibodies to bind to the receptors and mount more effective immune responses.

Engineered bone marrow cells slow growth of prostate and pancreatic cancer cells
In experiments with mice, researchers at the Johns Hopkins Kimmel Cancer Center say they have slowed the growth of transplanted human prostate and pancreatic cancer cells by introducing bone marrow cells with a specific gene deletion to induce a novel immune response.

First phase i clinical trial of CRISPR-edited cells for cancer shows cells safe and durable
Following the first US test of CRISPR gene editing in patients with advanced cancer, researchers report these patients experienced no negative side effects and that the engineered T cells persisted in their bodies -- for months.

Zika virus' key into brain cells ID'd, leveraged to block infection and kill cancer cells
Two different UC San Diego research teams identified the same molecule -- αvβ5 integrin -- as Zika virus' key to brain cell entry.

Read More: Cancer Cells News and Cancer Cells Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.